SitesBLAST – Find functional sites

 

SitesBLAST

Comparing GFF209 FitnessBrowser__WCS417:GFF209 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 3 hits to proteins with known functional sites (download)

4ymwC Crystal structure of an amino acid abc transporter with histidines (see paper)
25% identity, 89% coverage: 6:196/214 of query aligns to 15:201/214 of 4ymwC

query
sites
4ymwC
L
 
F
V
 
I
Q
 
S
G
 
G
A
 
L
I
 
I
D
 
M
T
 
T
L
 
L
L
 
K
M
 
L
V
 
T
G
 
F
V
 
L
S
 
A
S
 
V
L
 
T
I
 
I
A
 
G
L
 
V
L
 
L
V
 
M
G
 
G
I
 
L
P
 
F
L
 
I
A
 
A
V
 
L
F
 
M
L
 
K
V
 
M
T
 
S
S
 
S
D
 
I
K
 
K
G
 
-
G
 
-
I
 
-
Y
 
-
Q
 
-
A
 
-
P
 
-
A
 
P
L
 
I
N
 
K
R
 
L
V
 
V
L
 
A
G
 
S
A
 
S
F
 
Y
V
 
I
N
 
E
L
 
V
F
 
I
R
 
R
S
 
G
I
 
T
P
 
P
F
 
L
L
 
L
I
 
V
L
 
Q
M
 
L
V
 
L
-
 
L
-
 
I
-
 
Y
-
 
N
A
 
G
L
 
L
I
 
M
P
 
Q
F
 
F
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G
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M
L
 
N
I
 
I
V
 
P
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A
T
 
F
T
 
T
Y
 
A
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G
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V
W
 
S
A
 
A
A
 
-
V
 
-
V
 
-
P
 
-
L
 
L
T
 
A
I
 
I
A
x
N
A
 
S
T
 
S
P
 
A
F
x
Y
F
 
V
A
 
A
R
 
E
I
 
I
A
 
I
E
 
R
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A
S
 
G
L
 
I
R
 
Q
E
 
A
V
 
V
D
 
D
H
 
P
G
 
G
L
 
Q
I
 
N
E
 
E
A
 
A
A
 
A
Q
 
R
A
 
S
M
 
L
G
 
G
C
 
M
R
 
T
R
 
H
W
 
A
H
 
M
I
 
A
I
 
M
W
 
R
H
 
Y
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V
L
 
I
L
 
I
P
 
P
E
 
Q
A
 
A
L
 
I
P
 
K
G
 
N
I
 
I
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L
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P
G
 
A
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L
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G
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N
T
x
E
L
 
F
V
 
I
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V
M
 
M
I
 
L
N
 
K
S
x
E
S
 
S
A
 
A
M
 
I
A
 
V
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S
A
 
V
I
 
I
G
 
G
A
 
F
G
 
A
G
 
D
L
 
L
-
 
T
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R
-
 
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A
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D
I
 
I
A
 
I
Y
 
Q
R
 
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T
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Y
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Y
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E
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Y
I
 
I
M
 
I
L
 
I
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A
V
 
A
I
 
I
V
 
Y
L
 
F
L
 
V
V
 
M
L
 
T
L
 
L

4ymtC Crystal structure of an amino acid abc transporter complex with arginines (see paper)
25% identity, 89% coverage: 6:196/214 of query aligns to 15:201/215 of 4ymtC

query
sites
4ymtC
L
 
F
V
 
I
Q
 
S
G
 
G
A
 
L
I
 
I
D
 
M
T
 
T
L
 
L
L
 
K
M
 
L
V
 
T
G
 
F
V
 
L
S
 
A
S
 
V
L
 
T
I
 
I
A
 
G
L
 
V
L
 
L
V
 
M
G
 
G
I
 
L
P
 
F
L
 
I
A
 
A
V
 
L
F
 
M
L
 
K
V
 
M
T
 
S
S
 
S
D
 
I
K
 
K
G
 
-
G
 
-
I
 
-
Y
 
-
Q
 
-
A
 
-
P
 
-
A
 
P
L
 
I
N
 
K
R
 
L
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V
L
 
A
G
 
S
A
 
S
F
 
Y
V
 
I
N
 
E
L
 
V
F
 
I
R
 
R
S
 
G
I
 
T
P
|
P
F
x
L
L
 
L
I
 
V
L
 
Q
M
 
L
V
 
L
-
 
L
-
 
I
-
 
Y
-
 
N
A
 
G
L
 
L
I
 
M
P
 
Q
F
 
F
T
 
G
R
 
M
L
 
N
I
 
I
V
 
P
G
 
A
T
 
F
T
 
T
Y
 
A
G
 
G
V
 
V
W
 
S
A
 
A
A
 
-
V
 
-
V
 
-
P
 
-
L
 
L
T
 
A
I
 
I
A
x
N
A
 
S
T
 
S
P
 
A
F
x
Y
F
 
V
A
 
A
R
 
E
I
 
I
A
 
I
E
 
R
V
 
A
S
 
G
L
 
I
R
 
Q
E
 
A
V
 
V
D
 
D
H
 
P
G
 
G
L
 
Q
I
 
N
E
 
E
A
 
A
A
 
A
Q
 
R
A
 
S
M
 
L
G
 
G
C
 
M
R
 
T
R
 
H
W
 
A
H
 
M
I
 
A
I
 
M
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R
H
 
Y
V
 
V
L
 
I
L
 
I
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P
E
 
Q
A
 
A
L
 
I
P
 
K
G
 
N
I
 
I
V
 
L
G
 
P
G
 
A
F
 
L
T
 
G
I
 
N
T
x
E
L
 
F
V
 
I
T
 
V
M
|
M
I
 
L
N
x
K
S
x
E
S
 
S
A
 
A
M
 
I
A
 
V
G
 
S
A
 
V
I
 
I
G
 
G
A
 
F
G
 
A
G
 
D
L
 
L
-
 
T
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R
-
 
Q
G
 
A
D
 
D
I
 
I
A
 
I
Y
 
Q
R
 
S
Y
 
V
G
 
T
Y
 
Y
Q
 
R
R
 
Y
F
 
F
D
 
E
T
 
P
Q
 
Y
I
 
I
M
 
I
L
 
I
T
 
A
V
 
A
I
 
I
V
 
Y
L
 
F
L
 
V
V
 
M
L
 
T
L
 
L

A0A0H2ZQB9 Ergothioneine transporter EgtUBC from Streptococcus pneumoniae serotype 2 (strain D39 / NCTC 7466) (see paper)
32% identity, 52% coverage: 59:170/214 of query aligns to 60:165/506 of A0A0H2ZQB9

query
sites
A0A0H2ZQB9
L
 
I
F
 
F
R
 
Q
S
 
T
I
 
I
P
 
P
F
 
S
L
 
L
I
 
A
L
 
L
M
 
L
V
 
G
A
 
L
L
 
F
I
 
I
P
 
P
F
 
L
T
 
M
R
 
G
L
 
I
I
 
-
V
 
-
G
 
-
T
 
-
T
 
-
Y
 
-
G
 
G
V
 
T
W
 
L
A
 
P
A
 
A
V
 
L
V
 
T
P
 
A
L
 
L
T
 
V
I
 
I
A
 
Y
A
 
A
T
 
I
P
 
F
F
 
P
F
 
I
A
 
L
R
 
Q
I
 
N
A
 
T
E
 
I
V
 
T
S
 
G
L
 
L
R
 
K
E
 
G
V
 
I
D
 
D
H
 
P
G
 
S
L
 
L
I
 
Q
E
 
E
A
 
A
A
 
G
Q
 
I
A
 
A
M
 
F
G
 
G
C
 
M
R
 
T
R
 
R
W
 
W
H
 
E
I
 
R
I
 
L
W
 
K
H
 
K
V
 
F
L
 
E
L
 
I
P
 
P
E
 
L
A
 
A
L
 
M
P
 
P
G
 
V
I
 
I
V
 
M
G
 
S
G
 
G
F
 
I
T
 
R
I
 
T
T
 
A
L
 
A
V
 
V
T
 
L
M
 
I
I
 
I
N
 
G
S
 
T
S
 
A
A
 
T
M
 
L
A
 
A
G
 
T
A
 
L
I
 
I
G
 
G
A
 
A
G
 
G
G
 
G
L
 
L
G
 
G

Sites not aligning to the query:

Query Sequence

>GFF209 FitnessBrowser__WCS417:GFF209
MWFDRLVQGAIDTLLMVGVSSLIALLVGIPLAVFLVTSDKGGIYQAPALNRVLGAFVNLF
RSIPFLILMVALIPFTRLIVGTTYGVWAAVVPLTIAATPFFARIAEVSLREVDHGLIEAA
QAMGCRRWHIIWHVLLPEALPGIVGGFTITLVTMINSSAMAGAIGAGGLGDIAYRYGYQR
FDTQIMLTVIVLLVLLVAVIQLGGDRLARGLNKR

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory