Comparing GFF3341 FitnessBrowser__Marino:GFF3341 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
4y7uA Structural analysis of muru (see paper)
59% identity, 97% coverage: 1:224/232 of query aligns to 1:222/224 of 4y7uA
Q88QT2 N-acetylmuramate alpha-1-phosphate uridylyltransferase; MurNAc-1P uridylyltransferase; MurNAc-alpha-1P uridylyltransferase; EC 2.7.7.99 from Pseudomonas putida (strain ATCC 47054 / DSM 6125 / CFBP 8728 / NCIMB 11950 / KT2440) (see paper)
59% identity, 97% coverage: 1:224/232 of query aligns to 1:222/223 of Q88QT2
4y7vA Structural analysis of muru (see paper)
59% identity, 96% coverage: 1:222/232 of query aligns to 1:215/216 of 4y7vA
7d73E Cryo-em structure of gmppa/gmppb complex bound to gtp (state i) (see paper)
28% identity, 98% coverage: 1:227/232 of query aligns to 1:242/360 of 7d73E
7d72K Cryo-em structures of human gmppa/gmppb complex bound to gdp-mannose (see paper)
28% identity, 98% coverage: 1:227/232 of query aligns to 1:242/360 of 7d72K
7d72E Cryo-em structures of human gmppa/gmppb complex bound to gdp-mannose (see paper)
28% identity, 98% coverage: 1:227/232 of query aligns to 1:242/360 of 7d72E
P74285 UTP--glucose-1-phosphate uridylyltransferase; Cyanobacterial UDP-glucose pyrophosphorylase; UDP-glucose pyrophosphorylase; UDP-Glc PPase; EC 2.7.7.9 from Synechocystis sp. (strain PCC 6803 / Kazusa) (see paper)
31% identity, 94% coverage: 1:217/232 of query aligns to 1:242/388 of P74285
7whsA Cryo-em structure of leishmanial gdp-mannose pyrophosphorylase in complex with gtp (see paper)
27% identity, 91% coverage: 1:212/232 of query aligns to 1:223/366 of 7whsA
7whtA Cryo-em structure of leishmanial gdp-mannose pyrophosphorylase in complex with gdp-mannose (see paper)
37% identity, 52% coverage: 1:120/232 of query aligns to 1:120/360 of 7whtA
Sites not aligning to the query:
7x8kA Arabidopsis gdp-d-mannose pyrophosphorylase (vtc1) structure (product- bound) (see paper)
38% identity, 50% coverage: 1:117/232 of query aligns to 1:118/365 of 7x8kA
Sites not aligning to the query:
O22287 Mannose-1-phosphate guanylyltransferase 1; GDP-mannose pyrophosphorylase 1; Protein CYTOKINESIS DEFECTIVE 1; Protein EMBRYO DEFECTIVE 101; Protein HYPERSENSITIVE TO AMMONIUM ION 1; Protein SENSITIVE TO OZONE 1; Protein VITAMIN C DEFECTIVE 1; EC 2.7.7.13 from Arabidopsis thaliana (Mouse-ear cress) (see 5 papers)
38% identity, 50% coverage: 1:117/232 of query aligns to 1:118/361 of O22287
Sites not aligning to the query:
7x8kB Arabidopsis gdp-d-mannose pyrophosphorylase (vtc1) structure (product- bound) (see paper)
38% identity, 50% coverage: 1:117/232 of query aligns to 1:118/367 of 7x8kB
5z09A St0452(y97n)-utp binding form (see paper)
28% identity, 91% coverage: 1:211/232 of query aligns to 1:212/401 of 5z09A
2ggqA Complex of hypothetical glucose-1-phosphate thymidylyltransferase from sulfolobus tokodaii
28% identity, 91% coverage: 1:211/232 of query aligns to 1:212/401 of 2ggqA
Sites not aligning to the query:
Q975F9 Bifunctional sugar-1-phosphate nucleotidylyltransferase/acetyltransferase; EC 2.7.7.24; EC 2.7.7.9; EC 2.7.7.83; EC 2.7.7.23; EC 2.3.1.276; EC 2.3.1.157 from Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7) (Sulfolobus tokodaii) (see 3 papers)
28% identity, 91% coverage: 1:211/232 of query aligns to 1:212/401 of Q975F9
Sites not aligning to the query:
7d73B Cryo-em structure of gmppa/gmppb complex bound to gtp (state i) (see paper)
33% identity, 52% coverage: 1:120/232 of query aligns to 2:126/406 of 7d73B
Sites not aligning to the query:
7d72A Cryo-em structures of human gmppa/gmppb complex bound to gdp-mannose (see paper)
33% identity, 52% coverage: 1:120/232 of query aligns to 2:126/407 of 7d72A
Sites not aligning to the query:
6jq8A Crystal structure of hddc from yersinia pseudotuberculosis complexed with gmp-pn (see paper)
28% identity, 49% coverage: 3:116/232 of query aligns to 4:114/225 of 6jq8A
1h5tA Thymidylyltransferase complexed with thymidylyldiphosphate-glucose (see paper)
34% identity, 51% coverage: 2:120/232 of query aligns to 4:121/290 of 1h5tA
Sites not aligning to the query:
1h5rA Thymidylyltransferase complexed with thimidine and glucose-1-phospate (see paper)
34% identity, 51% coverage: 2:120/232 of query aligns to 4:121/290 of 1h5rA
Sites not aligning to the query:
>GFF3341 FitnessBrowser__Marino:GFF3341
MKAMILAAGKGERMRPLTLATPKPLLRAAGKPLITYHLEHLRRAGIREVVINHAWLGDQI
EETLGNGEGFGLSIQYSREGEPLETAGGIVRALPLLAGDKSDWFLAINGDIWSDFDLSGL
TPPPDADALLVVTSNPPHHPEGDFHLTDQGVLHSDGPDKLTFTGISLLHRRLFEGLSDQA
GKLGPVLRDAMSRGRVKGLFHPGQWVDVGTPERLQALDRQLGSKEPESHGRR
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory