SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing GFF3785 FitnessBrowser__psRCH2:GFF3785 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

1ji0A Crystal structure analysis of the abc transporter from thermotoga maritima
47% identity, 100% coverage: 1:234/234 of query aligns to 2:239/240 of 1ji0A

query
sites
1ji0A

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binding adenosine-5'-triphosphate: Y16 (= Y15), I19 (≠ S18), A21 (= A20), N41 (= N40), G42 (= G41), A43 (≠ V42), G44 (= G43), K45 (= K44), T46 (= T45), T47 (= T46), E88 (= E87), D164 (= D159), E165 (= E160)

6mjpB Lptb(e163q)fgc from vibrio cholerae (see paper)
33% identity, 89% coverage: 5:213/234 of query aligns to 2:215/240 of 6mjpB

query
sites
6mjpB

L

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binding 6-cyclohexylhexyl beta-D-glucopyranoside: R90 (≠ S93), K91 (≠ T94)

6mjpA Lptb(e163q)fgc from vibrio cholerae (see paper)
33% identity, 89% coverage: 5:213/234 of query aligns to 2:215/240 of 6mjpA

query
sites
6mjpA

L

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binding calcium ion: E111 (≠ A115), D115 (≠ Q119)

4u00A Crystal structure of ttha1159 in complex with adp (see paper)
34% identity, 93% coverage: 4:221/234 of query aligns to 1:223/241 of 4u00A

query
sites
4u00A

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binding adenosine-5'-diphosphate: F12 (≠ Y15), L15 (≠ S18), V17 (≠ A20), S37 (≠ N40), G38 (= G41), S39 (≠ V42), G40 (= G43), K41 (= K44), S42 (≠ T45), T43 (= T46)

6b8bA E. Coli lptb in complex with adp and a novobiocin derivative (see paper)
35% identity, 90% coverage: 6:215/234 of query aligns to 3:217/233 of 6b8bA

query
sites
6b8bA

L

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binding adenosine-5'-diphosphate: Y12 (= Y15), R15 (≠ S18), V17 (≠ A20), N37 (= N40), G38 (= G41), A39 (≠ V42), G40 (= G43), K41 (= K44), T42 (= T45), T43 (= T46)
binding (3s,5s,7s)-N-{7-[(3-O-carbamoyl-6-deoxy-5-methyl-4-O-methyl-beta-D-gulopyranosyl)oxy]-4-hydroxy-8-methyl-2-oxo-2H-1-benzopyran-3-yl}tricyclo[3.3.1.1~3,7~]decane-1-carboxamide: F89 (= F92), R90 (≠ S93), R91 (≠ T94)

6b89A E. Coli lptb in complex with adp and novobiocin (see paper)
35% identity, 90% coverage: 6:215/234 of query aligns to 3:217/234 of 6b89A

query
sites
6b89A

L

L

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R

A

A

R

R

H

R

G

G

I

I

G

G

Y
|
Y

V

L

P
|
P

E
x
Q

E
|
E

R
x
A

G
x
S

I

I

F
|
F

S
x
R

T
x
R

L
|
L

T

S

V

V

E

Y

E

D

N

N

L

L

T

-

L

M

P

A

P
x
V

V

L

V

Q

A

I

K

R

G

D

G

D

M

L

T

S

L

A

A

E

-

Q

-

R

-

E

-

D

-

R

-

A

-

N

E

E

I

L

Y

M

Q

E

L

E

F

F

P

-

N

H

L

I

E

E

E

H

R

L

R

R

K

D

S

S

P

M

G

G

T
x
Q

K

S

L

L

S

S

G

G

G

G

E

E

Q

R

Q

R

M

R

L

V

A

E

M

I

A

A

R
|
R

I

A

L

L

R

A

T

A

G

N

A

P

K

K

L

F

L

I

L

L

L

L

D

D

E

E

P

P

T

F

E

A

G

G

L

V

A

D

P

P

V

I

I

S

I

V

Q

I

R

D

I

I

G

K

E

R

V

I

L

I

Q

E

T

H

L

L

K

R

Q

D

R

S

G

G

M

L

T

G

I

V

L

L

L

I

V

T

E

D

Q

H

N

N

F

V

R

R

F

E

A

T

S

L

K

A

V

V

A

C

D

E

R

R

F

A

Y

Y

V

I

V

V

D

S

H

Q

G

G

Q

H

V

L

I

I

D

A

H

H

binding adenosine-5'-diphosphate: Y12 (= Y15), R15 (≠ S18), V17 (≠ A20), N37 (= N40), G38 (= G41), A39 (≠ V42), G40 (= G43), K41 (= K44), T42 (= T45), T43 (= T46)
binding magnesium ion: T42 (= T45), Q84 (≠ E87)
binding novobiocin: L71 (= L74), H72 (= H75), Y81 (= Y84), P83 (= P86), E85 (= E88), A86 (≠ R89), S87 (≠ G90), F89 (= F92), F89 (= F92), R90 (≠ S93), R91 (≠ T94), L92 (= L95), V101 (≠ P105), Q135 (≠ T133), R149 (= R147)

4p31A Crystal structure of a selenomethionine derivative of e. Coli lptb in complex with adp-magensium (see paper)
35% identity, 90% coverage: 6:215/234 of query aligns to 3:217/234 of 4p31A

query
sites
4p31A

L

L

S

T

V

A

R

K

D

N

L

L

N

A

A

K

W

A

Y
|
Y

G

K

E

G

S
x
R

H

R

A
x
V

L

V

H

E

G

D

I

V

D

S

L

L

D

T

V

V

H

N

A

S

G

G

E

E

T

I

V

V

T

G

L

L

L

L

G

G

R

P

N
|
N

G
|
G

V
x
A

G
|
G

K
|
K

T
|
T

T
|
T

A

T

L

F

R

Y

A

M

I

V

V

V

G

G

I

I

I

V

R

P

K

R

R

D

S

A

G

G

S

N

I

I

R

I

F

I

D

D

G

D

K

D

D

D

M

I

L

S

R

L

V

L

P

P

L

L

H

H

R

A

T

R

A

A

R

R

H

R

G

G

I

I

G

G

Y

Y

V

L

P

P

E
x
Q

E

E

R

A

G

S

I

I

F

F

S

R

T

R

L

L

T

S

V

V

E

Y

E

D

N

N

L

L

T

-

L

M

P

A

P

V

V

L

V

Q

A

I

K

R

G

D

G

D

M

L

T

S

L

A

A

E

-

Q

-

R

-

E

-

D

-

R

-

A

-

N

E

E

I

L

Y

M

Q

E

L

E

F

F

P

-

N

H

L

I

E

E

E

H

R

L

R

R

K

D

S

S

P

M

G

G

T

Q

K

S

L

L

S

S

G

G

G

G

E

E

Q

R

Q

R

M

R

L

V

A

E

M

I

A

A

R

R

I

A

L

L

R

A

T

A

G

N

A

P

K

K

L

F

L

I

L

L

L

L

D

D

E

E

P

P

T

F

E

A

G

G

L

V

A

D

P

P

V

I

I

S

I

V

Q

I

R

D

I

I

G

K

E

R

V

I

L

I

Q

E

T

H

L

L

K

R

Q

D

R

S

G

G

M

L

T

G

I

V

L

L

L

I

V

T

E

D

Q

H

N

N

F

V

R

R

F

E

A

T

S

L

K

A

V

V

A

C

D

E

R

R

F

A

Y

Y

V

I

V

V

D

S

H

Q

G

G

Q

H

V

L

I

I

D

A

H

H

binding adenosine-5'-diphosphate: Y12 (= Y15), R15 (≠ S18), V17 (≠ A20), N37 (= N40), G38 (= G41), A39 (≠ V42), G40 (= G43), K41 (= K44), T42 (= T45), T43 (= T46)
binding magnesium ion: T42 (= T45), Q84 (≠ E87)

6s8nB Cryo-em structure of lptb2fgc in complex with lipopolysaccharide (see paper)
35% identity, 90% coverage: 6:215/234 of query aligns to 3:217/238 of 6s8nB

query
sites
6s8nB

L

L

S

T

V

A

R

K

D

N

L

L

N

A

A

K

W

A

Y

Y

G

K

E

G

S

R

H

R

A

V

L

V

H

E

G

D

I

V

D

S

L

L

D

T

V

V

H

N

A

S

G

G

E

E

T

I

V

V

T

G

L

L

L

L

G

G

R

P

N

N

G

G

V

A

G

G

K

K

T

T

T

T

A

T

L

F

R

Y

A

M

I

V

V

V

G

G

I

I

I

V

R

P

K

R

R

D

S

A

G

G

S

N

I

I

R

I

F

I

D

D

G

D

K

D

D

D

M

I

L

S

R

L

V

L

P

P

L

L

H

H

R

A

T

R

A

A

R

R

H

R

G

G

I

I

G

G

Y

Y

V

L

P

P

E

Q

E

E

R

A

G

S

I

I

F

F

S
x
R

T

R

L

L

T

S

V

V

E

Y

E

D

N

N

L

L

T

-

L

M

P

A

P

V

V

L

V

Q

A

I

K

R

G

D

G

D

M

L

T

S

L

A

A

E

-

Q

-

R

-

E

-

D

-

R

-

A

-

N

E

E

I

L

Y

M

Q

E

L

E

F

F

P

-

N

H

L

I

E

E

E

H

R

L

R

R

K

D

S

S

P
x
M

G
|
G

T
x
Q

K

S

L

L

S

S

G

G

G

G

E

E

Q

R

Q

R

M

R

L

V

A

E

M

I

A

A

R

R

I

A

L

L

R

A

T

A

G

N

A

P

K

K

L

F

L

I

L

L

L

L

D

D

E

E

P

P

T

F

E

A

G

G

L

V

A

D

P

P

V

I

I

S

I

V

Q

I

R

D

I

I

G

K

E

R

V

I

L

I

Q

E

T

H

L

L

K

R

Q

D

R

S

G

G

M

L

T

G

I

V

L

L

L

I

V

T

E

D

Q

H

N

N

F

V

R

R

F

E

A

T

S

L

K

A

V

V

A

C

D

E

R

R

F

A

Y

Y

V

I

V

V

D

S

H

Q

G

G

Q

H

V

L

I

I

D

A

H

H

binding 2-decyl-5,6-dimethoxy-3-methylcyclohexa-2,5-diene-1,4-dione: R90 (≠ S93), M133 (≠ P131), G134 (= G132), Q135 (≠ T133)

6s8gA Cryo-em structure of lptb2fgc in complex with amp-pnp (see paper)
35% identity, 90% coverage: 6:215/234 of query aligns to 3:217/238 of 6s8gA

query
sites
6s8gA

L

L

S

T

V

A

R

K

D

N

L

L

N

A

A

K

W

A

Y
|
Y

G

K

E

G

S
x
R

H

R

A
x
V

L

V

H

E

G

D

I

V

D

S

L

L

D

T

V

V

H

N

A

S

G

G

E

E

T

I

V

V

T

G

L

L

L

L

G

G

R

P

N
|
N

G
|
G

V

A

G
|
G

K
|
K

T
|
T

T
|
T

A

T

L

F

R

Y

A

M

I

V

V

V

G

G

I

I

I

V

R

P

K

R

R

D

S

A

G

G

S

N

I

I

R

I

F

I

D

D

G

D

K

D

D

D

M

I

L

S

R

L

V

L

P

P

L

L

H

H

R

A

T

R

A

A

R

R

H

R

G

G

I

I

G

G

Y

Y

V

L

P

P

E
x
Q

E

E

R

A

G

S

I

I

F

F

S

R

T

R

L

L

T

S

V

V

E

Y

E

D

N

N

L

L

T

-

L

M

P

A

P

V

V

L

V

Q

A

I

K

R

G

D

G

D

M

L

T

S

L

A

A

E

-

Q

-

R

-

E

-

D

-

R

-

A

-

N

E

E

I

L

Y

M

Q

E

L

E

F

F

P

-

N

H

L

I

E

E

E

H

R

L

R

R

K

D

S

S

P

M

G

G

T

Q

K
x
S

L

L

S
|
S

G

G

G

G

E
|
E

Q

R

Q

R

M

R

L

V

A

E

M

I

A

A

R

R

I

A

L

L

R

A

T

A

G

N

A

P

K

K

L

F

L

I

L

L

L

L

D

D

E

E

P

P

T

F

E

A

G

G

L

V

A

D

P

P

V

I

I

S

I

V

Q

I

R

D

I

I

G

K

E

R

V

I

L

I

Q

E

T

H

L

L

K

R

Q

D

R

S

G

G

M

L

T

G

I

V

L

L

L

I

V

T

E

D

Q
x
H

N

N

F

V

R

R

F

E

A

T

S

L

K

A

V

V

A

C

D

E

R

R

F

A

Y

Y

V

I

V

V

D

S

H

Q

G

G

Q

H

V

L

I

I

D

A

H

H

binding phosphoaminophosphonic acid-adenylate ester: Y12 (= Y15), R15 (≠ S18), V17 (≠ A20), N37 (= N40), G38 (= G41), G40 (= G43), K41 (= K44), T42 (= T45), T43 (= T46), Q84 (≠ E87), S136 (≠ K134), S138 (= S136), E141 (= E139), H194 (≠ Q192)

6mhzA Vanadate trapped cryo-em structure of e.Coli lptb2fg transporter (see paper)
35% identity, 90% coverage: 6:215/234 of query aligns to 3:217/235 of 6mhzA

query
sites
6mhzA

L

L

S

T

V

A

R

K

D

N

L

L

N

A

A

K

W

A

Y
|
Y

G

K

E

G

S

R

H

R

A

V

L

V

H

E

G

D

I

V

D

S

L

L

D

T

V

V

H

N

A

S

G

G

E

E

T

I

V

V

T

G

L

L

L

L

G

G

R
x
P

N
|
N

G
|
G

V
x
A

G
|
G

K
|
K

T
|
T

T
|
T

A

T

L

F

R

Y

A

M

I

V

V

V

G

G

I

I

I

V

R

P

K

R

R

D

S

A

G

G

S

N

I

I

R

I

F

I

D

D

G

D

K

D

D

D

M

I

L

S

R

L

V

L

P

P

L

L

H

H

R

A

T

R

A

A

R

R

H

R

G

G

I

I

G

G

Y

Y

V

L

P

P

E
x
Q

E

E

R

A

G

S

I

I

F

F

S

R

T

R

L

L

T

S

V

V

E

Y

E

D

N

N

L

L

T

-

L

M

P

A

P

V

V

L

V

Q

A

I

K

R

G

D

G

D

M

L

T

S

L

A

A

E

-

Q

-

R

-

E

-

D

-

R

-

A

-

N

E

E

I

L

Y

M

Q

E

L

E

F

F

P

-

N

H

L

I

E

E

E

H

R

L

R

R

K

D

S

S

P

M

G

G

T

Q

K
x
S

L

L

S
|
S

G
|
G

G
|
G

E
|
E

Q

R

Q

R

M

R

L

V

A

E

M

I

A

A

R

R

I

A

L

L

R

A

T

A

G

N

A

P

K

K

L

F

L

I

L

L

L

L

D

D

E
|
E

P

P

T

F

E

A

G
|
G

L

V

A

D

P

P

V

I

I

S

I

V

Q

I

R

D

I

I

G

K

E

R

V

I

L

I

Q

E

T

H

L

L

K

R

Q

D

R

S

G

G

M

L

T

G

I

V

L

L

L

I

V

T

E

D

Q
x
H

N

N

F

V

R

R

F

E

A

T

S

L

K

A

V

V

A

C

D

E

R

R

F

A

Y

Y

V

I

V

V

D

S

H

Q

G

G

Q

H

V

L

I

I

D

A

H

H

binding adp orthovanadate: Y12 (= Y15), P36 (≠ R39), N37 (= N40), G38 (= G41), A39 (≠ V42), G40 (= G43), K41 (= K44), T42 (= T45), T43 (= T46), Q84 (≠ E87), S136 (≠ K134), S138 (= S136), G139 (= G137), G140 (= G138), E141 (= E139), E162 (= E160), G166 (= G164), H194 (≠ Q192)

6mbnA Lptb e163q in complex with atp (see paper)
35% identity, 90% coverage: 6:215/234 of query aligns to 4:218/241 of 6mbnA

query
sites
6mbnA

L

L

S

T

V

A

R

K

D

N

L

L

N

A

A

K

W

A

Y
|
Y

G

K

E

G

S
x
R

H

R

A
x
V

L

V

H

E

G

D

I

V

D

S

L

L

D

T

V

V

H

N

A

S

G

G

E

E

T

I

V

V

T

G

L

L

L

L

G

G

R
x
P

N
|
N

G
|
G

V
x
A

G
|
G

K
|
K

T
|
T

T
|
T

A

T

L

F

R

Y

A

M

I

V

V

V

G

G

I

I

I

V

R

P

K

R

R

D

S

A

G

G

S

N

I

I

R

I

F

I

D

D

G

D

K

D

D

D

M

I

L

S

R

L

V

L

P

P

L

L

H

H

R

A

T

R

A

A

R

R

H

R

G

G

I

I

G

G

Y

Y

V

L

P

P

E
x
Q

E

E

R

A

G

S

I

I

F

F

S

R

T

R

L

L

T

S

V

V

E

Y

E

D

N

N

L

L

T

-

L

M

P

A

P

V

V

L

V

Q

A

I

K

R

G

D

G

D

M

L

T

S

L

A

A

E

-

Q

-

R

-

E

-

D

-

R

-

A

-

N

E

E

I

L

Y

M

Q

E

L

E

F

F

P

-

N

H

L

I

E

E

E

H

R

L

R

R

K

D

S

S

P

M

G

G

T

Q

K

S

L

L

S

S

G

G

G

G

E

E

Q

R

Q

R

M

R

L

V

A

E

M

I

A

A

R

R

I

A

L

L

R

A

T

A

G

N

A

P

K

K

L

F

L

I

L

L

L

L

D

D

E

Q

P

P

T

F

E

A

G

G

L

V

A

D

P

P

V

I

I

S

I

V

Q

I

R

D

I

I

G

K

E

R

V

I

L

I

Q

E

T

H

L

L

K

R

Q

D

R

S

G

G

M

L

T

G

I

V

L

L

L

I

V

T

E

D

Q
x
H

N

N

F

V

R

R

F

E

A

T

S

L

K

A

V

V

A

C

D

E

R

R

F

A

Y

Y

V

I

V

V

D

S

H

Q

G

G

Q

H

V

L

I

I

D

A

H

H

binding adenosine-5'-triphosphate: Y13 (= Y15), R16 (≠ S18), V18 (≠ A20), P37 (≠ R39), N38 (= N40), G39 (= G41), A40 (≠ V42), G41 (= G43), K42 (= K44), T43 (= T45), T44 (= T46), Q85 (≠ E87), H195 (≠ Q192)

4ymuJ Crystal structure of an amino acid abc transporter complex with arginines and atps (see paper)
32% identity, 93% coverage: 5:221/234 of query aligns to 1:223/240 of 4ymuJ

query
sites
4ymuJ

L

M

L

I

S

F

V

V

R

N

D

D

L

V

N

Y

A

K

W

N

Y
x
F

G

G

E

S

S
x
L

H

E

A
x
V

L

L

H

K

G

G

I

V

D

T

L

L

D

K

V

V

H

N

A

K

G

G

E

E

T

V

V

V

T

V

L

I

L

I

G

G

R

P

N
x
S

G
|
G

V
x
S

G
|
G

K
|
K

T
x
S

T
|
T

A

L

L

L

R

R

A

C

I

I

V

N

G

L

I

L

I
x
E

R

E

K

P

R

T

S

K

G

G

S

E

I

V

R

F

F

I

D

D

G

G

K

V

D

K

M

I

L

N

-

N

-

G

R

K

V

V

P

N

L

I

H

N

R

K

T

V

A

-

R

R

H

Q

G

K

I

V

G

G

Y

M

V

V

P

F

E

Q

E

H

R

F

G

N

I

L

F

F

S

P

T

H

L

L

T

T

V

A

E

I

E

E

N

N

L

I

T

T

L

L

P

A

P

P

V

V

V

K

A

V

K

K

G

K

G

-

M

M

T

N

L

K

A

K

E

E

I

A

Y

E

Q

E

L

L

F

A

P

V

N

D

L

L

-

L

-

A

-

K

-

V

-

G

-

L

-

L

E

D

E

K

R

K

R

D

K

Q

S

Y

P

P

G

-

T

I

K

K

L

L

S

S

G

G

G

G

E

Q

Q

K

Q

Q

M

R

L

L

A

A

M

I

A

A

R

R

I

A

L

L

R

A

T

M

G

Q

A

P

K

E

L

V

L

M

L

L

L

F

D

D

E
|
E

P

P

T

T

E

S

G

A

L

L

A

D

P

P

V

E

I

M

I

V

Q

K

R

E

I

V

G

L

E

N

V

V

L

M

Q

K

T

Q

L

L

K

A

Q

N

R

E

G

G

M

M

T

T

I

M

L

V

L

V

V

V

E

T

Q
x
H

N

E

F

M

R

G

F

F

A

A

S

R

K

E

V

V

A

G

D

D

R

R

F

V

Y

I

V

F

V

M

D

D

H

D

G

G

Q

V

V

I

I

V

D

E

H

E

F

G

A

T

V

P

D

E

E

E

L

I

binding adenosine-5'-triphosphate: F11 (≠ Y15), L14 (≠ S18), V16 (≠ A20), S36 (≠ N40), G37 (= G41), S38 (≠ V42), G39 (= G43), K40 (= K44), S41 (≠ T45), T42 (= T46), E51 (≠ I55), E162 (= E160), H194 (≠ Q192)
binding magnesium ion: S41 (≠ T45), E162 (= E160)

3c4jA Abc protein artp in complex with atp-gamma-s
30% identity, 94% coverage: 5:224/234 of query aligns to 3:228/242 of 3c4jA

query
sites
3c4jA

L

M

L

I

S

D

V

V

R

H

D

Q

L

L

N

K

A

K

W

S

Y
x
F

G

G

E

S

S

L

H

E

A
x
V

L

L

H

K

G

G

I

I

D

N

L

V

D

H

V

I

H

R

A

E

G

G

E

E

T

V

V

V

T

V

L

V

L

I

G

G

R
x
P

N
x
S

G
|
G

V
x
S

G
|
G

K
|
K

T
x
S

T
|
T

A

F

L

L

R

R

A

C

I

L

V

N

G

L

I

L

I

E

R

D

K

F

R

D

S

E

G

G

S

E

I

I

R

I

F

I

D

D

G

G

K

I

D

N

M

L

L

K

R

A

V

K

P

D

L

T

H

N

-

L

R

N

T

K

A

V

R

R

H

E

G

E

I

V

G

G

Y

M

V

V

P

F

E

Q

E

R

R

F

G

N

I

L

F

F

S

P

T

H

L

M

T

T

V

V

E

L

E

N

N

N

L

I

T

T

L

L

P

A

P

P

V

M

V

K

A

V

K

R

G

K

G

W

-

P

-

R

-

E

M

K

T

A

L

E

A

A

E

K

I

A

Y

M

Q

E

L

L

F

L

P

D

N

K

-

V

-

G

L

L

E

K

E

D

R

K

R

A

K
x
H

S

A

P
x
Y

G

P

T

D

K

S

L

L

S

S

G

G

G

G

E

Q

Q

A

Q

Q

M

R

L

V

A

A

M

I

A

A

R

R

I

A

L

L

R

A

T

M

G

E

A

P

K

K

L

I

L

M

L

L

L

F

D

D

E
|
E

P

P

T

T

E

S

G

A

L

L

A

D

P

P

V

E

I

M

I

V

Q

G

R

E

I

V

G

L

E

S

V

V

L

M

Q

K

T

Q

L

L

K

A

Q

N

R

E

G

G

M

M

T

T

I

M

L

V

L

V

V

V

E

T

Q

H

N

E

F

M

R

G

F

F

A

A

S

R

K

E

V

V

A

G

D

D

R

R

F

V

Y

L

V

F

V

M

D

D

H

G

G

G

Q

Y

V

I

I

I

D

E

H

E

F

G

A

K

V

P

D

E

E

D

L

L

P

F

D

D

R

R

binding phosphothiophosphoric acid-adenylate ester: F13 (≠ Y15), V18 (≠ A20), P37 (≠ R39), S38 (≠ N40), G39 (= G41), S40 (≠ V42), G41 (= G43), K42 (= K44), S43 (≠ T45), T44 (= T46), H133 (≠ K129), Y135 (≠ P131), E164 (= E160)

3c41J Abc protein artp in complex with amp-pnp/mg2+
30% identity, 94% coverage: 5:224/234 of query aligns to 3:228/242 of 3c41J

query
sites
3c41J

L

M

L

I

S

D

V

V

R

H

D

Q

L

L

N

K

A

K

W

S

Y
x
F

G

G

E

S

S

L

H

E

A
x
V

L

L

H

K

G

G

I

I

D

N

L

V

D

H

V

I

H

R

A

E

G

G

E

E

T

V

V

V

T

V

L

V

L

I

G

G

R
x
P

N
x
S

G
|
G

V
x
S

G
|
G

K
|
K

T
x
S

T
|
T

A

F

L

L

R
|
R

A

C

I

L

V

N

G

L

I

L

I

E

R

D

K

F

R

D

S

E

G

G

S

E

I

I

R

I

F

I

D

D

G

G

K

I

D

N

M

L

L

K

R

A

V

K

P

D

L

T

H

N

-

L

R

N

T

K

A

V

R

R

H

E

G

E

I

V

G

G

Y

M

V

V

P

F

E

Q

E

R

R

F

G

N

I

L

F

F

S

P

T

H

L

M

T

T

V

V

E

L

E

N

N

N

L

I

T

T

L

L

P

A

P

P

V

M

V

K

A

V

K

R

G

K

G

W

-

P

-

R

-

E

M

K

T

A

L

E

A

A

E

K

I

A

Y

M

Q

E

L

L

F

L

P

D

N

K

-

V

-

G

L

L

E

K

E

D

R

K

R

A

K
x
H

S

A

P
x
Y

G

P

T

D

K

S

L

L

S

S

G

G

G

G

E

Q

Q

A

Q

Q

M

R

L

V

A

A

M

I

A

A

R

R

I

A

L

L

R

A

T

M

G

E

A

P

K

K

L

I

L

M

L

L

L

F

D
|
D

E

E

P

P

T

T

E

S

G

A

L

L

A

D

P

P

V

E

I

M

I

V

Q

G

R

E

I

V

G

L

E

S

V

V

L

M

Q

K

T

Q

L

L

K

A

Q

N

R

E

G

G

M

M

T

T

I

M

L

V

L

V

V

V

E

T

Q

H

N

E

F

M

R

G

F

F

A

A

S

R

K

E

V

V

A

G

D

D

R

R

F

V

Y

L

V

F

V

M

D

D

H

G

G

G

Q

Y

V

I

I

I

D

E

H

E

F

G

A

K

V

P

D

E

E

D

L

L

P

F

D

D

R

R

binding phosphoaminophosphonic acid-adenylate ester: F13 (≠ Y15), V18 (≠ A20), P37 (≠ R39), S38 (≠ N40), G39 (= G41), S40 (≠ V42), G41 (= G43), K42 (= K44), S43 (≠ T45), T44 (= T46), R47 (= R49), H133 (≠ K129), Y135 (≠ P131)
binding magnesium ion: S43 (≠ T45), D163 (= D159)

2olkA Abc protein artp in complex with adp-beta-s
30% identity, 94% coverage: 5:224/234 of query aligns to 3:228/242 of 2olkA

query
sites
2olkA

L

M

L

I

S

D

V

V

R

H

D

Q

L

L

N

K

A

K

W

S

Y
x
F

G

G

E

S

S
x
L

H

E

A
x
V

L

L

H

K

G

G

I

I

D

N

L

V

D

H

V

I

H

R

A

E

G

G

E

E

T

V

V

V

T

V

L

V

L

I

G

G

R

P

N
x
S

G
|
G

V
x
S

G
|
G

K
|
K

T
x
S

T
|
T

A

F

L

L

R

R

A

C

I

L

V

N

G

L

I

L

I

E

R

D

K

F

R

D

S

E

G

G

S

E

I

I

R

I

F

I

D

D

G

G

K

I

D

N

M

L

L

K

R

A

V

K

P

D

L

T

H

N

-

L

R

N

T

K

A

V

R

R

H

E

G

E

I

V

G

G

Y

M

V

V

P

F

E

Q

E

R

R

F

G

N

I

L

F

F

S

P

T

H

L

M

T

T

V

V

E

L

E

N

N

N

L

I

T

T

L

L

P

A

P

P

V

M

V

K

A

V

K

R

G

K

G

W

-

P

-

R

-

E

M

K

T

A

L

E

A

A

E

K

I

A

Y

M

Q

E

L

L

F

L

P

D

N

K

-

V

-

G

L

L

E

K

E

D

R

K

R

A

K

H

S

A

P

Y

G

P

T

D

K

S

L

L

S

S

G

G

G

G

E

Q

Q

A

Q

Q

M

R

L

V

A

A

M

I

A

A

R

R

I

A

L

L

R

A

T

M

G

E

A

P

K

K

L

I

L

M

L

L

L

F

D

D

E

E

P

P

T

T

E

S

G

A

L

L

A

D

P

P

V

E

I

M

I

V

Q

G

R

E

I

V

G

L

E

S

V

V

L

M

Q

K

T

Q

L

L

K

A

Q

N

R

E

G

G

M

M

T

T

I

M

L

V

L

V

V

V

E

T

Q

H

N

E

F

M

R

G

F

F

A

A

S

R

K

E

V

V

A

G

D

D

R

R

F

V

Y

L

V

F

V

M

D

D

H

G

G

G

Q

Y

V

I

I

I

D

E

H

E

F

G

A

K

V

P

D

E

E

D

L

L

P

F

D

D

R

R

binding 5'-o-[(r)-hydroxy(thiophosphonooxy)phosphoryl]adenosine: F13 (≠ Y15), L16 (≠ S18), V18 (≠ A20), S38 (≠ N40), G39 (= G41), S40 (≠ V42), G41 (= G43), K42 (= K44), S43 (≠ T45), T44 (= T46)

2oljA Abc protein artp in complex with adp/mg2+
30% identity, 94% coverage: 5:224/234 of query aligns to 3:228/242 of 2oljA

query
sites
2oljA

L

M

L

I

S

D

V

V

R

H

D

Q

L

L

N

K

A

K

W

S

Y
x
F

G

G

E

S

S

L

H

E

A
x
V

L

L

H

K

G

G

I

I

D

N

L

V

D

H

V

I

H

R

A

E

G

G

E

E

T

V

V

V

T

V

L

V

L

I

G

G

R

P

N
x
S

G
|
G

V
x
S

G
|
G

K
|
K

T
x
S

T
|
T

A

F

L

L

R

R

A

C

I

L

V

N

G

L

I

L

I

E

R

D

K

F

R

D

S

E

G

G

S

E

I

I

R

I

F

I

D

D

G

G

K

I

D

N

M

L

L

K

R

A

V

K

P

D

L

T

H

N

-

L

R

N

T

K

A

V

R

R

H

E

G

E

I

V

G

G

Y

M

V

V

P

F

E

Q

E

R

R

F

G

N

I

L

F

F

S

P

T

H

L

M

T

T

V

V

E

L

E

N

N

N

L

I

T

T

L

L

P

A

P

P

V

M

V

K

A

V

K

R

G

K

G

W

-

P

-

R

-

E

M

K

T

A

L

E

A

A

E

K

I

A

Y

M

Q

E

L

L

F

L

P

D

N

K

-

V

-

G

L

L

E

K

E

D

R

K

R

A

K
x
H

S

A

P
x
Y

G

P

T

D

K

S

L

L

S

S

G

G

G

G

E

Q

Q

A

Q

Q

M

R

L

V

A

A

M

I

A

A

R

R

I

A

L

L

R

A

T

M

G

E

A

P

K

K

L

I

L

M

L

L

L

F

D

D

E

E

P

P

T

T

E

S

G

A

L

L

A

D

P

P

V

E

I

M

I

V

Q

G

R

E

I

V

G

L

E

S

V

V

L

M

Q

K

T

Q

L

L

K

A

Q

N

R

E

G

G

M

M

T

T

I

M

L

V

L

V

V

V

E

T

Q

H

N

E

F

M

R

G

F

F

A

A

S

R

K

E

V

V

A

G

D

D

R

R

F

V

Y

L

V

F

V

M

D

D

H

G

G

G

Q

Y

V

I

I

I

D

E

H

E

F

G

A

K

V

P

D

E

E

D

L

L

P

F

D

D

R

R

binding adenosine-5'-diphosphate: F13 (≠ Y15), V18 (≠ A20), S38 (≠ N40), G39 (= G41), S40 (≠ V42), G41 (= G43), K42 (= K44), S43 (≠ T45), T44 (= T46), H133 (≠ K129), Y135 (≠ P131)

P75831 Macrolide export ATP-binding/permease protein MacB; EC 7.6.2.- from Escherichia coli (strain K12) (see paper)
30% identity, 90% coverage: 4:213/234 of query aligns to 3:222/648 of P75831

query
sites
P75831

P

P

L

L

L

L

S

E

V

L

R

K

D

D

L

I

N

R

A

R

W

S

Y

Y

-

P

-

A

-

G

-

D

G

E

E

Q

S

V

H

E

A

V

L

L

H

K

G

G

I

I

D

S

L

L

D

D

V

I

H

Y

A

A

G

G

E

E

T

M

V

V

T

A

L

I

L

V

G

G

R

A

N

S

G

G

V

S

G

G

K
|
K

T

S

T

T

A

L

L

M

R

N

A

I

I

L

V

G

G

C

I

L

I

D

R

K

K

A

R

T

S

S

G

G

S

T

I

Y

R

R

F

V

D

A

G

G

K

Q

D

D

M

V

L

A

R

T

V

L

-

D

-

A

-

D

P

A

L

L

H

A

R

Q

T

L

A

R

R

R

H

E

G

H

I

F

G

G

Y

F

V

I

P

F

E

Q

E

R

R

Y

G

H

I

L

F

L

S

S

T

H

L

L

T

T

V

A

E

E

E

Q

N

N

L

V

T

E

L

V

P

P

P

A

V

V

V

Y

A

A

-

G

-

L

-

E

-

R

K

K

G

Q

G

R

M

L

T

L

L

R

A

A

E

Q

I

E

Y

L

Q

L

L

Q

F

R

P

L

N

G

L

L

E

E

E

D

R

R

R

T

K

E

S

Y

P

Y

G

P

T

A

K

Q

L

L

S

S

G

G

G

G

E

Q

Q

Q

Q

Q

M

R

L

V

A

S

M

I

A

A

R

R

I

A

L

L

R

M

T

N

G

G

A

G

K

Q

L

V

L

I

L

L

L

A

D
|
D

E

E

P

P

T

T

E

G

G

A

L

L

A

D

P

S

V

H

I

S

I

G

Q

E

R

E

I

V

G

M

E

A

V

I

L

L

Q

H

T

Q

L

L

K

R

Q

D

R

R

G

G

M

H

T

T

I

V

L

I

L

I

V

V

E

T

Q

H

N

D

F

P

R

Q

F

V

A

A

S

A

K

Q

V

-

A

A

D

E

R

R

F

V

Y

I

V

E

V

I

D

R

H

D

G

G

Q

E

V

I

I

V

K47 (= K44) mutation to L: Lack of activity.
D169 (= D159) mutation to N: Lack of activity.

4yerA Crystal structure of an abc transporter atp-binding protein (tm_1403) from thermotoga maritima msb8 at 2.35 a resolution
32% identity, 90% coverage: 3:213/234 of query aligns to 2:215/285 of 4yerA

query
sites
4yerA

E

E

P

D

L

I

L

I

S

V

V

V

R

E

D

N

L

L

N

V

A

K

W

K

Y
x
F

G

G

E

D

S
x
F

H

E

A
|
A

L

V

H

K

G

G

I

V

D

S

L

F

D

S

V

V

H

K

A

K

G

G

E

E

T

I

V

F

T

A

L

F

L

L

G

G

R
x
P

N
|
N

G
|
G

V
x
A

G
|
G

K
|
K

T
|
T

T
|
T

A

T

L

I

R

H

A

M

I

L

V

T

G

T

I

L

I

L

R

K

K

P

R

T

S

S

G

G

S

K

I

A

R

W

F

V

D

A

G

G

K

H

D

D

M

V

L

L

R

K

V

E

P

P

L

-

H

-

R

R

T

E

A

V

R

R

H

R

G

K

I

I

G

G

Y

I

V

V

P

F

E

Q

E

D

R

Q

G

S

I

L

F

D

S

R

T

E

L

L

T

T

V

A

E

Y

E

E

N

N

L

M

T

Y

L

I

P

H

-

G

P

K

V

I

V

Y

A

G

K

Y

G

G

G

G

M

E

T

K

L

L

A

K

E

K

-

R

-

I

-

L

I

E

Y

L

Q

L

L

E

F

F

P

V

N

E

L

L

E

L

E

E

R

F

R

K

K

D

S

K

P

P

G

V

T

K

K
x
T

L
x
F

S
|
S

G

G

G

G

E

M

Q

A

Q

R

M

R

L

L

A

E

M

I

A

A

R

R

I

S

L

L

R

I

T

H

G

E

A

P

K

E

L

V

L

L

L

F

L

L

D

D

E

E

P

P

T

T

E

I

G

G

L

L

A

D

P

P

V

H

I

T

I

R

Q

A

R

H

I

M

G

W

E

E

V

Y

L

I

Q

S

T

K

L

M

-

K

K

K

Q

E

R

H

G

N

M

M

T

T

I

I

L

F

L

L

V

T

E

T

Q

H

N

Y

F

M

R

D

F

E

A

A

S

E

K

Q

V

L

A

A

D

D

R

R

F

V

Y

A

V

I

V

I

D

D

H

H

G

G

Q

K

V

I

I

I

binding adenosine-5'-diphosphate: F14 (≠ Y15), F17 (≠ S18), A19 (= A20), P38 (≠ R39), N39 (= N40), G40 (= G41), A41 (≠ V42), G42 (= G43), K43 (= K44), T44 (= T45), T45 (= T46), T135 (≠ K134), F136 (≠ L135), S137 (= S136)

5lilA Structure of aggregatibacter actinomycetemcomitans macb bound to atpys (p21) (see paper)
29% identity, 90% coverage: 5:214/234 of query aligns to 3:222/615 of 5lilA

query
sites
5lilA

L

I

L

I

S

E

V

I

R

K

D

Q

L

L

N

N

A

R

W

Y

Y
x
F

G

G

E

E

S

G

-

E

-

N

-

R

-

V

H

H

A
x
V

L

L

H

K

G

D

I

I

D

S

L

L

D

S

V

I

H

E

A

R

G

G

E

D

T

F

V

V

T

A

L

I

L

M

G

G

R

Q

N
x
S

G
|
G

V
x
S

G
|
G

K
|
K

T
x
S

T
|
T

A

L

L

M

R

N

A

I

I

I

V

G

G

C

I

L

I

D

R

T

K

A

R

T

S

G

G

G

S

S

I

S

R

K

F

I

D

D

G

G

K

K

D

E

M

T

L

I

R

E

V

L

P

T

-

N

-

D

-

Q

L

L

H

S

R

D

T

L

A

R

R

S

H

Q

G

K

I

F

G

G

Y

F

V

I

P

F

E
x
Q

E

R

R

Y

G

N

I

L

F

L

S

S

T

S

L

L

T

T

V

A

E

A

E

E

N

N

L

V

T

A

L

L

P

P

P

A

V

I

V

Y

A

A

K

-

G

-

G

G

M

M

-

P

-

Q

-

S

-

Q

T

R

L

L

A

E

E

R

I

A

Y

K

Q

Q

L

L

F

L

P

E

N

K

L

L

E

G

-

L

-

G

E

D

R
x
K

R

W

K

Q

S
x
N

P

K

G

P

T

N

K
x
Q

L
|
L

S
|
S

G
|
G

G
|
G

E
x
Q

Q

Q

Q

Q

M

R

L

V

A

S

M

I

A

A

R

R

I

A

L

L

R

M

T

N

G

G

A

G

K

E

L

I

L

I

L

L

L

A

D
|
D

E
x
Q

P

P

T

T

E

G

G
x
A

L

L

A

D

P

S

V

H

I

S

I

G

Q

E

R

N

I

V

G

M

E

E

V

I

L

L

Q

R

T

Q

L

L

K

H

Q

E

R

E

G

G

M

H

T

T

I

I

L

I

L

M

V

V

E

T

Q
x
H

N

D

F

K

R

H

F

I

A

A

S

A

K

S

V

-

A

A

D

N

R

R

F

I

Y

I

V

E

V

I

D

K

H

D

G

G

Q

E

V

I

I

I

D

S

binding adenosine-5'-triphosphate: F13 (≠ Y15), V22 (≠ A20), S42 (≠ N40), G43 (= G41), S44 (≠ V42), G45 (= G43), K46 (= K44), S47 (≠ T45), T48 (= T46), Q92 (≠ E87), K136 (≠ R127), N139 (≠ S130), Q143 (≠ K134), L144 (= L135), S145 (= S136), G146 (= G137), G147 (= G138), Q148 (≠ E139), Q169 (≠ E160), A173 (≠ G164), H201 (≠ Q192)
binding magnesium ion: S47 (≠ T45), Q92 (≠ E87), D168 (= D159)

5lj7A Structure of aggregatibacter actinomycetemcomitans macb bound to atp (p21) (see paper)
29% identity, 89% coverage: 5:213/234 of query aligns to 3:221/592 of 5lj7A

query
sites
5lj7A

L

I

L

I

S

E

V

I

R

K

D

Q

L

L

N

N

A

R

W

Y

Y
x
F

G

G

E

E

S

G

-

E

-

N

-

R

-

V

H

H

A
x
V

L

L

H

K

G

D

I

I

D

S

L

L

D

S

V

I

H

E

A

R

G

G

E

D

T

F

V

V

T

A

L

I

L

M

G

G

R

Q

N
x
S

G
|
G

V
x
S

G
|
G

K
|
K

T
x
S

T
|
T

A

L

L

M

R

N

A

I

I

I

V

G

G

C

I

L

I

D

R

T

K

A

R

T

S

G

G

G

S

S

I

S

R

K

F

I

D

D

G

G

K

K

D

E

M

T

L

I

R

E

V

L

P

T

-

N

-

D

-

Q

L

L

H

S

R

D

T

L

A

R

R

S

H

Q

G

K

I

F

G

G

Y

F

V

I

P

F

E
x
Q