Comparing H281DRAFT_00597 FitnessBrowser__Burk376:H281DRAFT_00597 to proteins with known functional sites using BLASTp with E ≤ 0.001.
Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures
Found 20 (the maximum) hits to proteins with known functional sites (download)
4o23A Crystal structure of mono-zinc form of succinyl diaminopimelate desuccinylase from neisseria meningitidis mc58 (see paper)
62% identity, 99% coverage: 4:379/379 of query aligns to 5:376/376 of 4o23A
4pqaA Crystal structure of succinyl-diaminopimelate desuccinylase from neisseria meningitidis mc58 in complex with the inhibitor captopril (see paper)
62% identity, 99% coverage: 4:378/379 of query aligns to 5:375/375 of 4pqaA
7t1qA Crystal structure of the succinyl-diaminopimelate desuccinylase (dape) from acinetobacter baumannii in complex with succinic acid
61% identity, 96% coverage: 16:379/379 of query aligns to 17:376/377 of 7t1qA
7lgpB Dape enzyme from shigella flexneri
57% identity, 99% coverage: 4:379/379 of query aligns to 7:377/377 of 7lgpB
5vo3A Crystal structure of dape in complex with the products (succinic acid and diaminopimelic acid) (see paper)
51% identity, 99% coverage: 5:378/379 of query aligns to 10:379/380 of 5vo3A
P44514 Succinyl-diaminopimelate desuccinylase; SDAP desuccinylase; N-succinyl-LL-2,6-diaminoheptanedioate amidohydrolase; EC 3.5.1.18 from Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd) (see 3 papers)
51% identity, 99% coverage: 5:378/379 of query aligns to 6:375/377 of P44514
4op4B Crystal structure of the catalytic domain of dape protein from v.Cholerea in the zn bound form (see paper)
61% identity, 48% coverage: 2:183/379 of query aligns to 3:180/265 of 4op4B
Sites not aligning to the query:
4h2kA Crystal structure of the catalytic domain of succinyl-diaminopimelate desuccinylase from haemophilus influenzae (see paper)
54% identity, 49% coverage: 5:190/379 of query aligns to 8:187/258 of 4h2kA
Sites not aligning to the query:
7uoiA Crystallographic structure of dape from enterococcus faecium
24% identity, 99% coverage: 5:379/379 of query aligns to 11:383/383 of 7uoiA
7rsfA Acetylornithine deacetylase from escherichia coli
26% identity, 93% coverage: 27:377/379 of query aligns to 35:377/380 of 7rsfA
3pfoA Crystal structure of a putative acetylornithine deacetylase (rpa2325) from rhodopseudomonas palustris cga009 at 1.90 a resolution
32% identity, 38% coverage: 58:200/379 of query aligns to 93:224/426 of 3pfoA
Sites not aligning to the query:
Q03154 Aminoacylase-1; ACY-1; N-acyl-L-amino-acid amidohydrolase; EC 3.5.1.14 from Homo sapiens (Human) (see 6 papers)
24% identity, 82% coverage: 69:377/379 of query aligns to 79:398/408 of Q03154
Q96KN2 Beta-Ala-His dipeptidase; CNDP dipeptidase 1; Carnosine dipeptidase 1; Glutamate carboxypeptidase-like protein 2; Serum carnosinase; EC 3.4.13.20 from Homo sapiens (Human) (see 4 papers)
30% identity, 34% coverage: 65:192/379 of query aligns to 127:254/507 of Q96KN2
Sites not aligning to the query:
Q8C165 N-fatty-acyl-amino acid synthase/hydrolase PM20D1; Peptidase M20 domain-containing protein 1; PM20D1; EC 3.5.1.114; EC 3.5.1.14 from Mus musculus (Mouse) (see paper)
35% identity, 25% coverage: 69:163/379 of query aligns to 124:217/503 of Q8C165
Sites not aligning to the query:
3dljA Crystal structure of human carnosine dipeptidase 1
32% identity, 27% coverage: 65:166/379 of query aligns to 96:197/471 of 3dljA
Sites not aligning to the query:
Q96KP4 Cytosolic non-specific dipeptidase; CNDP dipeptidase 2; Glutamate carboxypeptidase-like protein 1; Peptidase A; Threonyl dipeptidase; EC 3.4.13.18 from Homo sapiens (Human)
24% identity, 54% coverage: 63:266/379 of query aligns to 92:315/475 of Q96KP4
Sites not aligning to the query:
2pokA Crystal structure of a m20 family metallo peptidase from streptococcus pneumoniae
22% identity, 82% coverage: 62:371/379 of query aligns to 83:455/458 of 2pokA
Sites not aligning to the query:
P37111 Aminoacylase-1; ACY-1; N-acyl-L-amino-acid amidohydrolase; EC 3.5.1.14 from Sus scrofa (Pig) (see paper)
22% identity, 81% coverage: 70:377/379 of query aligns to 80:397/407 of P37111
Sites not aligning to the query:
2zogA Crystal structure of mouse carnosinase cn2 complexed with zn and bestatin (see paper)
43% identity, 15% coverage: 63:118/379 of query aligns to 96:151/478 of 2zogA
Sites not aligning to the query:
2zofA Crystal structure of mouse carnosinase cn2 complexed with mn and bestatin (see paper)
43% identity, 15% coverage: 63:118/379 of query aligns to 96:151/478 of 2zofA
Sites not aligning to the query:
>H281DRAFT_00597 FitnessBrowser__Burk376:H281DRAFT_00597
MSGTLALTEQLIARASVTPDDQHCQRLLIERLSALGFEHETIESNGVTNLWAVKRGVDGR
AGKLLAFAGHTDVVPTGPLEQWQSAPFEPTHRDGKLYGRGAADMKTSIAGFVVASEEFVA
AHPRHRGSIAFLITSDEEGPATDGTVKVVEALQARGERMDYCIVGEPTSSTQFGDTVKNG
RRGSMSGKLVVKGVQGHIAYPHLARNPVHLLAPALAELVAERWDDGNEYFPPTTWQVSNI
HSGTGATNVIPGHADVMFNFRFSTASTVEGLQQRVHAILDRHGLEYDLQWTVSGLPFLTP
HGDLSNALAKAIKDETGVSTELSTTGGTSDGRFIARICQQVVEFGPLNASIHKIDEHIDV
AHIEPLKNVYRRVLEQLIA
Or try a new SitesBLAST search
SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory