Comparing H281DRAFT_03420 FitnessBrowser__Burk376:H281DRAFT_03420 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 17 hits to proteins with known functional sites (download)
2gwgA Crystal structure of 4-oxalomesaconate hydratase, ligj, from rhodopseudomonas palustris, northeast structural genomics target rpr66.
77% identity, 100% coverage: 1:341/341 of query aligns to 1:326/329 of 2gwgA
G2IQQ5 2-keto-4-carboxy-3-hexenedioate hydratase; KCH hydratase; EC 4.2.1.- from Sphingobium sp. (strain NBRC 103272 / SYK-6) (see paper)
63% identity, 100% coverage: 1:340/341 of query aligns to 3:340/341 of G2IQQ5
6dxsA Crystal structure of the ligj hydratase e284q mutant substrate complex with (3z)-2-keto-4-carboxy-3-hexenedioate (see paper)
63% identity, 100% coverage: 1:340/341 of query aligns to 2:339/342 of 6dxsA
6dxqA Crystal structure of the ligj hydratase product complex with 4- carboxy-4-hydroxy-2-oxoadipate (see paper)
63% identity, 99% coverage: 2:340/341 of query aligns to 1:337/338 of 6dxqA
6e6iA Crystal structure of 4-methyl hopda bound to ligy from sphingobium sp. Strain syk-6
33% identity, 96% coverage: 1:329/341 of query aligns to 1:328/332 of 6e6iA
5vn5C Crystal structure of ligy from sphingobium sp. Strain syk-6 (see paper)
33% identity, 96% coverage: 1:329/341 of query aligns to 1:328/334 of 5vn5C
4infA Crystal structure of amidohydrolase saro_0799 (target efi-505250) from novosphingobium aromaticivorans dsm 12444 with bound calcium
22% identity, 73% coverage: 81:329/341 of query aligns to 99:349/351 of 4infA
Sites not aligning to the query:
4qrnA High-resolution crystal structure of 5-carboxyvanillate decarboxylase (target efi-505250) from novosphingobium aromaticivorans dsm 12444 complexed with manganese and 4-hydroxy-3-methoxy-5-nitrobenzoic acid
22% identity, 73% coverage: 81:329/341 of query aligns to 100:350/352 of 4qrnA
Sites not aligning to the query:
7pwyA Structure of human dimeric acmsd in complex with the inhibitor tes- 1025 (see paper)
22% identity, 80% coverage: 54:325/341 of query aligns to 58:323/334 of 7pwyA
Sites not aligning to the query:
4ih3A 2.5 angstroms x-ray crystal structure of of human 2-amino-3- carboxymuconate-6-semialdehyde decarboxylase in complex with dipicolinic acid (see paper)
22% identity, 80% coverage: 54:325/341 of query aligns to 59:324/332 of 4ih3A
Sites not aligning to the query:
2wm1A The crystal structure of human alpha-amino-beta-carboxymuconate- epsilon-semialdehyde decarboxylase in complex with 1,3- dihydroxyacetonephosphate suggests a regulatory link between NAD synthesis and glycolysis (see paper)
22% identity, 80% coverage: 54:325/341 of query aligns to 59:324/332 of 2wm1A
Sites not aligning to the query:
4ofcA 2.0 angstroms x-ray crystal structure of human 2-amino-3- carboxymuconate-6-semialdehye decarboxylase (see paper)
22% identity, 80% coverage: 54:325/341 of query aligns to 59:324/335 of 4ofcA
Sites not aligning to the query:
7pwyC Structure of human dimeric acmsd in complex with the inhibitor tes- 1025 (see paper)
21% identity, 80% coverage: 54:325/341 of query aligns to 49:294/301 of 7pwyC
Sites not aligning to the query:
Q8TDX5 2-amino-3-carboxymuconate-6-semialdehyde decarboxylase; Picolinate carboxylase; EC 4.1.1.45 from Homo sapiens (Human) (see paper)
22% identity, 80% coverage: 54:325/341 of query aligns to 59:324/336 of Q8TDX5
Sites not aligning to the query:
3ij6A Crystal structure of an uncharacterized metal-dependent hydrolase from lactobacillus acidophilus
23% identity, 61% coverage: 81:289/341 of query aligns to 66:266/303 of 3ij6A
Sites not aligning to the query:
4qroA Crystal structure of dihydroxybenzoic acid decarbboxylase bpro_2061 (target efi-500288) from polaromonas sp. Js666 with bound manganese and an inhibitor, 2-nitroresorcinol
23% identity, 84% coverage: 45:329/341 of query aligns to 31:322/332 of 4qroA
Sites not aligning to the query:
Q12BV1 Gamma-resorcylate decarboxylase; Gamma-RSD; 2,6-dihydroxybenzoate decarboxylase; 2,6-DHBD; EC 4.1.1.103 from Polaromonas sp. (strain JS666 / ATCC BAA-500) (see paper)
23% identity, 84% coverage: 45:329/341 of query aligns to 31:322/326 of Q12BV1
Sites not aligning to the query:
>H281DRAFT_03420 FitnessBrowser__Burk376:H281DRAFT_03420
MIIDIHGHYTTAPKALEAWRNRQIAALGNPTDAPKPSELQISDDELRESIETNQLRLMRE
RRLDLTVFSPRASFMAHHIGNFDVSSTWAAICNELCYRVSQLFPEHFIPAAMLPQSPGVD
VATCIPELVKCVEQYGNVAINLNPDPSGGHWTSPPLSDRYWYPIYEKMVEYDIPAMVHVS
TSCNACFHTTGAHYLNADTTAFMQCLTSDLFRDFPTLRFVIPHGGGAVPYHWGRFRGLAQ
EMKKPLLEKHLLKNIFFDTCVYHQPGIDLLTNVIPVDNILFASEMIGAVRGIDPQTGHYF
DDTKRYVEAAAMNPEQRHQIYEGNARRVYPRLDAALKAQGR
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory