SitesBLAST – Find functional sites

 

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Comparing LRK54_RS03535 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree

Found 10 hits to proteins with known functional sites (download)

7unr1 50S ribosomal protein L36
53% identity, 93% coverage: 1:57/61 of query aligns to 1:57/61 of 7unr1

query
sites
7unr1
M
 
M
A
 
K
S
 
A
K
 
N
D
 
E
I
 
L
N
x
R
N
 
E
Q
 
K
S
 
S
A
 
V
E
 
E
E
 
Q
L
 
L
Q
 
N
Q
 
E
H
 
Q
L
 
L
L
 
L
D
 
G
L
 
L
R
 
L
K
 
R
E
 
D
Q
 
Q
F
 
F
N
 
N
L
 
L
R
 
R
M
 
M
Q
 
Q
K
 
K
G
 
A
S
 
T
G
 
G
Q
 
Q
L
 
L
T
 
G
Q
|
Q
P
x
S
H
|
H
Q
 
L
L
 
L
R
x
S
R
 
Q
V
 
V
R
 
K
R
|
R
D
 
D
I
 
I
A
|
A
R
|
R
T
 
V
K
|
K
F
x
T
V
 
V
L
 
L

5adyY Cryo-em structures of the 50s ribosome subunit bound with hflx (see paper)
55% identity, 98% coverage: 1:60/61 of query aligns to 1:60/63 of 5adyY

query
sites
5adyY
M
|
M
A
x
K
S
 
A
K
|
K
D
 
E
I
 
L
N
 
R
N
 
E
Q
 
K
S
 
S
A
 
V
E
 
E
E
 
E
L
 
L
Q
 
N
Q
 
T
H
 
E
L
 
L
L
 
L
D
 
N
L
 
L
R
 
L
K
 
R
E
 
E
Q
 
Q
F
 
F
N
 
N
L
 
L
R
 
R
M
 
M
Q
 
Q
K
 
A
G
 
A
S
 
S
G
 
G
Q
 
Q
L
 
L
T
 
Q
Q
 
Q
P
x
S
H
|
H
Q
 
L
L
 
L
R
x
K
R
 
Q
V
 
V
R
|
R
R
 
R
D
 
D
I
 
V
A
|
A
R
 
R
T
 
V
K
|
K
F
x
T
V
 
L
L
 
L
G
x
N
G
 
E
K
 
K

6spbY Pseudomonas aeruginosa 50s ribosome from a clinical isolate with a mutation in ul6 (see paper)
63% identity, 67% coverage: 17:57/61 of query aligns to 20:57/60 of 6spbY

query
sites
6spbY
H
 
H
L
 
L
L
 
L
D
 
-
L
 
-
R
 
-
K
 
R
E
 
D
Q
 
Q
F
 
F
N
 
N
L
 
L
R
 
R
M
 
M
Q
 
Q
K
|
K
G
 
A
S
 
T
G
 
G
Q
 
Q
L
 
L
T
 
G
Q
|
Q
P
x
S
H
|
H
Q
 
L
L
 
L
R
 
S
R
 
Q
V
 
V
R
x
K
R
|
R
D
 
D
I
 
I
A
|
A
R
|
R
T
 
V
K
|
K
F
x
T
V
 
V
L
 
L

Sites not aligning to the query:

9c4gx Cutibacterium acnes 50s ribosomal subunit with clindamycin bound (see paper)
40% identity, 93% coverage: 1:57/61 of query aligns to 2:58/69 of 9c4gx

query
sites
9c4gx
M
 
L
A
 
S
S
x
A
K
 
A
D
 
E
I
 
L
N
x
R
N
 
Q
Q
 
L
S
 
S
A
 
G
E
 
E
E
 
E
L
 
L
Q
 
R
Q
 
N
H
 
K
L
 
V
L
 
R
D
 
E
L
 
L
R
 
K
K
 
E
E
 
E
Q
 
L
F
 
F
N
 
G
L
 
L
R
 
R
M
 
F
Q
 
Q
K
 
S
G
 
A
S
 
T
G
 
G
Q
 
Q
L
 
L
T
 
E
Q
x
N
P
x
T
H
x
A
Q
 
R
L
|
L
R
|
R
R
 
E
V
 
V
R
 
R
R
x
K
D
 
D
I
 
I
A
|
A
R
|
R
T
 
V
K
x
Y
F
x
T
V
 
V
L
 
L

Sites not aligning to the query:

8buuY 50S ribosomal protein L13 (see paper)
39% identity, 93% coverage: 1:57/61 of query aligns to 1:57/66 of 8buuY

query
sites
8buuY
M
 
M
A
 
K
S
x
A
K
 
N
D
 
E
I
 
I
N
x
R
N
 
D
Q
 
L
S
 
T
A
 
T
E
 
A
E
 
E
L
 
I
Q
 
E
Q
 
Q
H
 
K
L
 
V
L
 
K
D
 
S
L
 
L
R
 
K
K
 
E
E
 
E
Q
 
L
F
 
F
N
 
N
L
 
L
R
 
R
M
 
F
Q
 
Q
K
x
L
G
 
A
S
 
T
G
 
G
Q
 
Q
L
 
L
T
 
E
Q
x
N
P
x
T
H
x
A
Q
 
R
L
 
I
R
|
R
R
x
E
V
 
V
R
|
R
R
x
K
D
 
A
I
 
I
A
|
A
R
|
R
T
 
M
K
|
K
F
x
T
V
 
V
L
 
I

Sites not aligning to the query:

6v39X 30S ribosomal protein S18 (see paper)
41% identity, 95% coverage: 3:60/61 of query aligns to 2:59/62 of 6v39X

query
sites
6v39X
S
 
T
K
 
K
D
 
D
I
 
L
N
x
R
N
 
E
Q
 
K
S
 
S
A
 
V
E
 
E
E
 
E
L
 
L
Q
 
K
Q
 
A
H
 
L
L
 
L
L
 
D
D
 
E
L
 
Q
R
 
Q
K
 
L
E
 
N
Q
 
Q
F
 
F
N
 
R
L
 
L
R
 
R
M
 
M
Q
 
A
K
 
K
G
 
A
S
 
T
G
 
G
Q
 
Q
L
 
L
T
 
G
Q
 
K
P
 
S
H
|
H
Q
 
E
L
 
V
R
 
Q
R
 
V
V
 
A
R
 
R
R
x
K
D
 
T
I
 
I
A
 
A
R
|
R
T
 
I
K
|
K
F
x
T
V
 
L
L
 
L
G
x
T
G
 
E
K
 
K

7asmW Staphylococcus aureus 50s after 30 minutes incubation at 37c
37% identity, 89% coverage: 3:56/61 of query aligns to 2:55/67 of 7asmW

query
sites
7asmW
S
 
A
K
 
K
D
 
E
I
 
I
N
x
R
N
 
D
Q
 
L
S
 
T
A
 
T
E
 
S
E
 
E
L
 
I
Q
 
E
Q
 
E
H
 
Q
L
 
I
L
 
K
D
 
S
L
 
S
R
 
K
K
 
E
E
 
E
Q
 
L
F
 
F
N
 
N
L
 
L
R
 
R
M
 
F
Q
 
Q
K
 
L
G
 
A
S
 
T
G
 
G
Q
 
Q
L
 
L
T
x
E
Q
 
E
P
x
T
H
x
A
Q
 
R
L
 
I
R
|
R
R
 
T
V
 
V
R
|
R
R
x
K
D
 
T
I
 
I
A
 
A
R
|
R
T
 
L
K
|
K
F
x
T
V
 
V

Sites not aligning to the query:

8uu51 Small ribosomal subunit protein uS9 (see paper)
40% identity, 90% coverage: 3:57/61 of query aligns to 2:56/61 of 8uu51

query
sites
8uu51
S
 
A
K
 
N
D
 
D
I
 
I
N
x
R
N
 
D
Q
 
L
S
 
S
A
 
T
E
 
T
E
 
E
L
 
I
Q
 
Q
Q
 
D
H
 
Q
L
 
E
L
 
K
D
 
A
L
 
L
R
 
K
K
 
E
E
 
E
Q
 
L
F
 
F
N
 
N
L
 
L
R
 
R
M
 
F
Q
 
Q
K
 
L
G
 
A
S
 
T
G
 
G
Q
 
Q
L
 
L
T
 
E
Q
x
N
P
x
T
H
x
A
Q
 
R
L
 
I
R
|
R
R
 
E
V
 
V
R
|
R
R
x
K
D
 
A
I
 
I
A
|
A
R
|
R
T
 
M
K
|
K
F
x
T
V
 
I
L
 
V

Sites not aligning to the query:

5myjB1 of 70S ribosome from Lactococcus lactis (see paper)
42% identity, 87% coverage: 4:56/61 of query aligns to 10:62/67 of 5myjB1

query
sites
5myjB1
K
 
K
D
 
D
I
 
L
N
 
R
N
 
A
Q
 
L
S
 
S
A
 
V
E
 
E
E
 
E
L
 
L
Q
 
T
Q
 
T
H
 
R
L
 
E
L
 
A
D
 
E
L
 
L
R
 
K
K
 
K
E
 
E
Q
 
L
F
 
F
N
 
D
L
 
L
R
 
R
M
 
F
Q
 
Q
K
 
A
G
 
A
S
 
A
G
 
G
Q
 
R
L
 
L
T
x
E
Q
x
N
P
x
T
H
x
A
Q
 
K
L
|
L
R
 
D
R
 
E
V
 
V
R
 
K
R
x
K
D
 
T
I
 
I
A
|
A
R
|
R
T
 
V
K
|
K
F
x
T
V
|
V

Sites not aligning to the query:

7mscY 70SIC in complex with MtbEttA at Pre_R0 state (see paper)
39% identity, 93% coverage: 1:57/61 of query aligns to 1:57/68 of 7mscY

query
sites
7mscY
M
 
V
A
 
S
S
 
P
K
 
G
D
 
E
I
 
L
N
x
R
N
 
E
Q
 
L
S
 
T
A
 
D
E
 
E
E
 
E
L
 
L
Q
 
A
Q
 
E
H
 
R
L
 
L
L
 
R
D
 
E
L
 
S
R
 
K
K
 
E
E
 
E
Q
 
L
F
 
F
N
 
N
L
 
L
R
 
R
M
 
F
Q
 
Q
K
 
M
G
 
A
S
 
T
G
 
G
Q
 
Q
L
 
L
T
x
N
Q
x
N
P
x
N
H
x
R
Q
 
R
L
 
L
R
|
R
R
 
T
V
 
V
R
|
R
R
 
Q
D
 
E
I
 
I
A
|
A
R
|
R
T
 
I
K
x
Y
F
x
T
V
 
V
L
 
L

Sites not aligning to the query:

Query Sequence

>LRK54_RS03535
MASKDINNQSAEELQQHLLDLRKEQFNLRMQKGSGQLTQPHQLRRVRRDIARTKFVLGGK
K

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory