Comparing Pf6N2E2_3170 FitnessBrowser__pseudo6_N2E2:Pf6N2E2_3170 to proteins with known functional sites using BLASTp with E ≤ 0.001.
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Found 20 (the maximum) hits to proteins with known functional sites (download)
P9WQB3 2-isopropylmalate synthase; Alpha-IPM synthase; Alpha-isopropylmalate synthase; EC 2.3.3.13 from Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) (see 2 papers)
52% identity, 97% coverage: 7:550/559 of query aligns to 42:642/644 of P9WQB3
Sites not aligning to the query:
3hq1A Crystal structure of mycobacterium tuberculosis leua complexed with citrate and mn2+
54% identity, 97% coverage: 7:550/559 of query aligns to 25:572/573 of 3hq1A
1sr9A Crystal structure of leua from mycobacterium tuberculosis (see paper)
54% identity, 97% coverage: 7:550/559 of query aligns to 25:572/573 of 1sr9A
3figB Crystal structure of leucine-bound leua from mycobacterium tuberculosis (see paper)
54% identity, 97% coverage: 7:550/559 of query aligns to 25:575/577 of 3figB
3hpzB Crystal structure of mycobacterium tuberculosis leua complexed with bromopyruvate
54% identity, 97% coverage: 7:550/559 of query aligns to 25:575/576 of 3hpzB
3hpsA Crystal structure of mycobacterium tuberculosis leua complexed with ketoisocaproate (kic)
53% identity, 97% coverage: 7:550/559 of query aligns to 25:574/575 of 3hpsA
4ov4A Isopropylmalate synthase binding with ketoisovalerate (see paper)
29% identity, 70% coverage: 40:433/559 of query aligns to 11:379/379 of 4ov4A
4ov9A Structure of isopropylmalate synthase binding with alpha- isopropylmalate (see paper)
29% identity, 70% coverage: 40:431/559 of query aligns to 11:379/380 of 4ov9A
Q9JZG1 2-isopropylmalate synthase; Alpha-IPM synthase; Alpha-isopropylmalate synthase; EC 2.3.3.13 from Neisseria meningitidis serogroup B (strain MC58) (see 2 papers)
27% identity, 94% coverage: 34:559/559 of query aligns to 8:514/517 of Q9JZG1
Sites not aligning to the query:
Q9FN52 Methylthioalkylmalate synthase 3, chloroplastic; 2-isopropylmalate synthase 2; Methylthioalkylmalate synthase-like; EC 2.3.3.17 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
29% identity, 64% coverage: 40:399/559 of query aligns to 92:444/503 of Q9FN52
6e1jA Crystal structure of methylthioalkylmalate synthase (bjumam1.1) from brassica juncea (see paper)
27% identity, 65% coverage: 38:399/559 of query aligns to 23:377/409 of 6e1jA
3rmjB Crystal structure of truncated alpha-isopropylmalate synthase from neisseria meningitidis (see paper)
31% identity, 52% coverage: 38:329/559 of query aligns to 9:288/308 of 3rmjB
Q9FG67 Methylthioalkylmalate synthase 1, chloroplastic; 2-isopropylmalate synthase 3; EC 2.3.3.17 from Arabidopsis thaliana (Mouse-ear cress) (see paper)
25% identity, 60% coverage: 38:370/559 of query aligns to 90:412/506 of Q9FG67
6ktqA Crystal structure of catalytic domain of homocitrate synthase from sulfolobus acidocaldarius (sahcs(dram)) in complex with alpha- ketoglutarate/zn2+/coa (see paper)
25% identity, 71% coverage: 36:434/559 of query aligns to 25:368/399 of 6ktqA
2ztjA Crystal structure of homocitrate synthase from thermus thermophilus complexed with alpha-ketoglutarate (see paper)
27% identity, 47% coverage: 38:300/559 of query aligns to 9:239/312 of 2ztjA
O87198 Homocitrate synthase; HCS; EC 2.3.3.14 from Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27) (see paper)
27% identity, 47% coverage: 38:300/559 of query aligns to 9:247/376 of O87198
2zyfA Crystal structure of homocitrate synthase from thermus thermophilus complexed with magnesuim ion and alpha-ketoglutarate (see paper)
26% identity, 47% coverage: 38:300/559 of query aligns to 9:241/314 of 2zyfA
3a9iA Crystal structure of homocitrate synthase from thermus thermophilus complexed with lys (see paper)
26% identity, 47% coverage: 38:300/559 of query aligns to 8:240/347 of 3a9iA
Q53WI0 4-hydroxy-2-oxovalerate aldolase; HOA; 4-hydroxy-2-keto-pentanoic acid aldolase; 4-hydroxy-2-oxohexanoate aldolase; 4-hydroxy-2-oxopentanoate aldolase; EC 4.1.3.39; EC 4.1.3.43 from Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8) (see paper)
35% identity, 15% coverage: 243:327/559 of query aligns to 198:278/347 of Q53WI0
Sites not aligning to the query:
Q8F3Q1 (R)-citramalate synthase CimA; LiCMS; EC 2.3.3.21 from Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601) (see 2 papers)
25% identity, 27% coverage: 212:363/559 of query aligns to 176:318/516 of Q8F3Q1
Sites not aligning to the query:
>Pf6N2E2_3170 FitnessBrowser__pseudo6_N2E2:Pf6N2E2_3170
MSMLKDPSSKYRAFPTINLPDRTWPSKTITAAPIWCSSDLRDGNQSLIEPMDAVKKLRFW
KTLVAVGVKEIEASFPAASQTDFDFVRTLIEEGHIPDDTTIQVLTQAREDLIARTFESLR
GAKKAIVHLYNATCPSFRRIVFNQDKEGVKEIAVNAAKLFVKYAAQQPETQWQFEYSPET
FSATELEFAKEVCDAVIEVWNPTPERKVILNLPATVEVATPNIYADQIEWFHRNISRRDS
VLISLHTHNDRGTGVAATELGLMAGADRVEGCLFGNGERTGNVDLVTVALNLYTQGVNPE
LDFSDIDGVRKVVEECNQIPVHPRHPYVGDLVHTAFSGSHQDAIRKGFAQQKSDGLWEVP
YLPIDPADIGRSYEAVIRVNSQSGKGGIAYLLEQEYGISLPRRMQIEFSQVVQRETDRLG
LEMTAQQIHALLQREYLQANTPYALVSHRLQEENGNSAVEVEVASKGQGETNLHWRGKGN
GALEALVAGLPIPVEIMDYNEHAIGAGTNAKAAAYIELRVNGERAVHGVGIDENITTASF
KALFSALNRSLSQPEAKAA
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SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.
Lawrence Berkeley National Laboratory