SitesBLAST

SitesBLAST – Find functional sites

SitesBLAST

Comparing Synpcc7942_0931 Synpcc7942_0931 UDP-N-acetylglucosamine acyltransferase to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 20 (the maximum) hits to proteins with known functional sites (download)

4eqyG Crystal structure of acyl-[acyl-carrier-protein]--udp-n- acetylglucosamine o-acyltransferase from burkholderia thailandensis (see paper)
42% identity, 94% coverage: 5:256/268 of query aligns to 2:255/260 of 4eqyG

query
sites
4eqyG

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binding : E52 (= E55), D82 (= D85)

6p9tA E.Coli lpxa in complex with udp-3-o-(r-3-hydroxymyristoyl)-glcnac and compound 8 (see paper)
45% identity, 90% coverage: 2:241/268 of query aligns to 5:241/263 of 6p9tA

query
sites
6p9tA

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active site: H125 (= H121), D126 (≠ N122), G143 (= G139)
binding [3-(5-amino-4-methylpyridin-2-yl)-1H-pyrazol-5-yl]{(3R)-3-[(2-chloro-6-methoxyphenyl)methyl]morpholin-4-yl}methanone: H160 (= H156), H191 (≠ P187)
binding uridine-5'-diphosphate-3-O-(R-3-hydroxymyristoyl)-N-acetyl-D-glucosamine: D74 (= D71), L75 (≠ K72), K76 (= K73), H122 (= H118), A124 (= A120), H125 (= H121), A142 (= A138), G143 (= G139), H144 (= H140), A158 (≠ G154), Q161 (= Q157)

6p9sA E.Coli lpxa in complex with udp-3-o-(r-3-hydroxymyristoyl)-glcnac and compound 7 (see paper)
45% identity, 90% coverage: 2:241/268 of query aligns to 5:241/263 of 6p9sA

query
sites
6p9sA

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active site: H125 (= H121), D126 (≠ N122), G143 (= G139)
binding {(3R)-3-[(2-methoxyphenyl)methyl]morpholin-4-yl}[3-(4-methylpyridin-2-yl)-1H-pyrazol-5-yl]methanone: H160 (= H156), H191 (≠ P187)
binding uridine-5'-diphosphate-3-O-(R-3-hydroxymyristoyl)-N-acetyl-D-glucosamine: D74 (= D71), L75 (≠ K72), K76 (= K73), H122 (= H118), A124 (= A120), H125 (= H121), T140 (≠ S136), A142 (= A138), G143 (= G139), H144 (= H140), A158 (≠ G154), Q161 (= Q157), H191 (≠ P187)

6p9rA E.Coli lpxa in complex with udp-3-o-(r-3-hydroxymyristoyl)-glcnac and compound 6 (see paper)
45% identity, 90% coverage: 2:241/268 of query aligns to 5:241/263 of 6p9rA

query
sites
6p9rA

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active site: H125 (= H121), D126 (≠ N122), G143 (= G139)
binding {(3R)-3-[(2-fluorophenyl)methyl]morpholin-4-yl}[3-(4-methylpyridin-2-yl)-1H-pyrazol-5-yl]methanone: H160 (= H156), H191 (≠ P187)
binding uridine-5'-diphosphate-3-O-(R-3-hydroxymyristoyl)-N-acetyl-D-glucosamine: L75 (≠ K72), K76 (= K73), H122 (= H118), A124 (= A120), H125 (= H121), T140 (≠ S136), A142 (= A138), G143 (= G139), H144 (= H140), A158 (≠ G154), Q161 (= Q157)

6p9qA E.Coli lpxa in complex with udp-3-o-(r-3-hydroxymyristoyl)-glcnac and compound 2 (see paper)
45% identity, 90% coverage: 2:241/268 of query aligns to 5:241/263 of 6p9qA

query
sites
6p9qA

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V

V

P

P

Y

Y

M

V

L

I

V

A

E

Q

G

G

N

N

P
x
H

A

A

R

T

V

P

R

F

S

G

L

V

N

N

L

I

V

E

G

G

L

L

E

K

R

R

A

R

G

G

L

F

R

S

D

R

G

-

Q

-

E

-

G

-

E

E

A

A

F

I

K

T

Q

A

L

I

K

R

Q

N

A

A

Y

Y

R

K

L

L

L

I

Y

Y

R

R

S

S

D

G

L

K

L

T

L

L

K

D

E

E

A

V

I

K

A

P

E

E

I

I

R

A

Q

E

I

L

S

A

D

E

active site: H125 (= H121), D126 (≠ N122), G143 (= G139)
binding [(3R)-3-benzylmorpholin-4-yl][5-(4-methylpyridin-2-yl)-1H-pyrazol-3-yl]methanone: H160 (= H156), H191 (≠ P187)
binding uridine-5'-diphosphate-3-O-(R-3-hydroxymyristoyl)-N-acetyl-D-glucosamine: D74 (= D71), L75 (≠ K72), K76 (= K73), H122 (= H118), A124 (= A120), H125 (= H121), T140 (≠ S136), A142 (= A138), G143 (= G139), H144 (= H140), A158 (≠ G154), Q161 (= Q157)

6p9pA E.Coli lpxa in complex with compound 1 (see paper)
45% identity, 90% coverage: 2:241/268 of query aligns to 5:241/263 of 6p9pA

query
sites
6p9pA

S

S

A

A

V

F

I

V

H

H

P

P

T

T

A

A

I

I

I

V

A

E

P

E

G

G

A

A

E

S

I

I

H

G

P

A

S

N

V

A

Q

H

I

I

G

G

P

P

Y

F

A

C

V

I

I

V

G

G

E

P

H

H

V

V

R

E

I

I

G

G

A

E

H

G

T

T

T

V

V

L

G

K

A

S

H

H

A

V

V

V

I

V

D

N

G

G

W

H

T

T

E

K

I

I

G

G

E

R

E

D

N

N

R

E

I

I

F

Y

P

Q

G

F

A

A

A

S

I

I

G

G

L

E

E

V

S

N

Q

Q

D

D

K

L

K

K

T

Y

D

A

G

G

S

E

L

P

S

T

V

R

V

V

R

E

I

I

G

G

D

D

R

R

N

N

R

R

I

I

R

R

E

E

Y

S

V

V

T

T

I

I

N

H

R

R

A

G

T

T

-

V

K

Q

A

G

G

G

E

G

A

L

T

T

V

K

I

V

G

G

N

S

D

D

N

N

L

L

M

M

A

I

Y

N

V

A

H

H

V

I

A

A

H
|
H

N
x
D

C

C

I

T

L

V

H

G

N

N

R

R

I

C

V

I

I

L

S

A

N

N

A

N

V

A

S

T

L

L

A
|
A

G
|
G

H

H

I

V

V

S

V

V

E

D

S

D

G

F

A

A

V

I

I

I

G

G

M

M

S

T

G
x
A

L

V

H
|
H

Q
|
Q

F

F

V

C

H

I

V

I

G

G

R

A

N

H

A

V

M

M

I

V

G

G

M

C

S

S

R
x
G

V

V

E

A

R

Q

D

D

V

V

P

P

Y

Y

M

V

L

I

V

A

E

Q

G

G

N

N

P
x
H

A

A

R

T

V

P

R

F

S

G

L

V

N

N

L

I

V

E

G

G

L

L

E

K

R

R

A

R

G

G

L

F

R

S

D

R

G

-

Q

-

E

-

G

-

E

E

A

A

F

I

K

T

Q

A

L

I

K

R

Q

N

A

A

Y

Y

R

K

L

L

L

I

Y

Y

R

R

S

S

D

G

L

K

L

T

L

L

K

D

E

E

A

V

I

K

A

P

E

E

I

I

R

A

Q

E

I

L

S

A

D

E

active site: H125 (= H121), D126 (≠ N122), G143 (= G139)
binding 3-[2-(4-methoxyphenyl)-2-oxoethyl]-5,5-diphenylimidazolidine-2,4-dione: A142 (= A138), A158 (≠ G154), H160 (= H156), Q161 (= Q157), G176 (≠ R172), H191 (≠ P187)

2qivX Structural basis for the acyl chain selectivity and mechanism of udp- n-acetylglucosamine acyltransferase (see paper)
45% identity, 90% coverage: 2:241/268 of query aligns to 5:241/262 of 2qivX

query
sites
2qivX

S

S

A

A

V

F

I

V

H

H

P

P

T

T

A

A

I

I

I

V

A

E

P

E

G

G

A

A

E

S

I

I

H

G

P

A

S

N

V

A

Q

H

I

I

G

G

P

P

Y

F

A

C

V

I

I

V

G

G

E

P

H

H

V

V

R

E

I

I

G

G

A

E

H

G

T

T

T

V

V

L

G

K

A

S

H

H

A

V

V

V

I

V

D

N

G

G

W

H

T

T

E

K

I

I

G

G

E

R

E

D

N

N

R

E

I

I

F

Y

P

Q

G

F

A

A

A

S

I

I

G

G

L

E

E

V

S

N

Q
|
Q

D
|
D

K
x
L

K
|
K

T

Y

D

A

G

G

S

E

L

P

S

T

V

R

V

V

R

E

I

I

G

G

D

D

R

R

N

N

R

R

I

I

R

R

E

E

Y

S

V

V

T

T

I

I

N

H

R

R

A

G

T

T

-

V

K

Q

A

G

G

G

E

G

A

L

T

T

V

K

I

V

G

G

N

S

D

D

N

N

L

L

M

M

A

I

Y

N

V

A

H
|
H

V

I

A
|
A

H
|
H

N
x
D

C

C

I

T

L

V

H

G

N

N

R

R

I

C

V

I

I

L

S

A

N

N

A

N

V

A

S
x
T

L

L

A

A

G
|
G

H
|
H

I

V

V

S

V

V

E

D

S

D

G

F

A

A

V

I

I

I

G

G

M

M

S

T

G

A

L

V

H

H

Q
|
Q

F

F

V

C

H

I

V

I

G

G

R

A

N

H

A

V

M

M

I

V

G

G

M

C

S

S

R

G

V

V

E

A

R

Q

D

D

V

V

P

P

Y

Y

M

V

L

I

V

A

E

Q

G

G

N

N

P

H

A

A

R

T

V

P

R

F

S

G

L

V

N

N

L

I

V

E

G

G

L

L

E

K

R

R

A

R

G

G

L

F

R

S

D

R

G

-

Q

-

E

-

G

-

E

E

A

A

F

I

K

T

Q

A

L

I

K

R

Q

N

A

A

Y

Y

R

K

L

L

L

I

Y

Y

R

R

S

S

D

G

L

K

L

T

L

L

K

D

E

E

A

V

I

K

A

P

E

E

I

I

R

A

Q

E

I

L

S

A

D

E

active site: H125 (= H121), D126 (≠ N122), G143 (= G139)
binding uridine-5'-diphosphate-3-O-(R-3-hydroxydecanoyl)-N-acetyl-D-glucosamine: Q73 (= Q70), D74 (= D71), L75 (≠ K72), K76 (= K73), H122 (= H118), A124 (= A120), H125 (= H121), T140 (≠ S136), G143 (= G139), H144 (= H140), Q161 (= Q157)

2qiaA Structural basis for the acyl chain selectivity and mechanism of udp- n-acetylglucosamine acyltransferase (see paper)
45% identity, 90% coverage: 2:241/268 of query aligns to 5:241/262 of 2qiaA

query
sites
2qiaA

S

S

A

A

V

F

I

V

H

H

P

P

T

T

A

A

I

I

I

V

A

E

P

E

G

G

A

A

E

S

I

I

H

G

P

A

S

N

V

A

Q

H

I

I

G

G

P

P

Y

F

A

C

V

I

I

V

G

G

E

P

H

H

V

V

R

E

I

I

G

G

A

E

H

G

T

T

T

V

V

L

G

K

A

S

H

H

A

V

V

V

I

V

D

N

G

G

W

H

T

T

E

K

I

I

G

G

E

R

E

D

N

N

R

E

I

I

F

Y

P

Q

G

F

A

A

A

S

I

I

G

G

L

E

E

V

S

N

Q

Q

D

D

K
x
L

K
|
K

T

Y

D

A

G

G

S

E

L

P

S

T

V

R

V

V

R

E

I

I

G

G

D

D

R

R

N

N

R

R

I

I

R

R

E

E

Y

S

V

V

T

T

I

I

N

H

R

R

A

G

T

T

-

V

K

Q

A

G

G

G

E

G

A

L

T

T

V

K

I

V

G

G

N

S

D

D

N

N

L

L

M

M

A

I

Y

N

V

A

H
|
H

V

I

A
|
A

H
|
H

N
x
D

C

C

I

T

L

V

H

G

N

N

R

R

I

C

V

I

I

L

S

A

N

N

A

N

V

A

S
x
T

L

L

A
|
A

G
|
G

H
|
H

I

V

V

S

V

V

E

D

S

D

G

F

A

A

V

I

I

I

G

G

M

M

S

T

G
x
A

L

V

H

H

Q
|
Q

F
|
F

V

C

H

I

V

I

G

G

R

A

N

H

A

V

M

M

I

V

G

G

M

C

S

S

R

G

V

V

E

A

R

Q

D

D

V

V

P

P

Y

Y

M

V

L

I

V

A

E

Q

G

G

N

N

P
x
H

A

A

R

T

V

P

R

F

S

G

L

V

N

N

L

I

V

E

G

G

L

L

E

K

R

R

A

R

G

G

L

F

R

S

D

R

G

-

Q

-

E

-

G

-

E

E

A

A

F

I

K

T

Q

A

L

I

K

R

Q

N

A

A

Y

Y

R

K

L

L

L

I

Y

Y

R

R

S

S

D

G

L

K

L

T

L

L

K

D

E

E

A

V

I

K

A

P

E

E

I

I

R

A

Q

E

I

L

S

A

D

E

active site: H125 (= H121), D126 (≠ N122), G143 (= G139)
binding uridine-5'-diphosphate-3-O-(R-3-hydroxymyristoyl)-N-acetyl-D-glucosamine: L75 (≠ K72), K76 (= K73), H122 (= H118), A124 (= A120), H125 (= H121), T140 (≠ S136), A142 (= A138), G143 (= G139), H144 (= H140), A158 (≠ G154), Q161 (= Q157), F162 (= F158), H191 (≠ P187)

2jf3A Nucleotide substrate binding by udp-n-acetylglucosamine acyltransferase (see paper)
45% identity, 90% coverage: 2:241/268 of query aligns to 5:241/262 of 2jf3A

query
sites
2jf3A

S

S

A

A

V

F

I

V

H

H

P

P

T

T

A

A

I

I

I

V

A

E

P

E

G

G

A

A

E

S

I

I

H

G

P

A

S

N

V

A

Q

H

I

I

G

G

P

P

Y

F

A

C

V

I

I

V

G

G

E

P

H

H

V

V

R

E

I

I

G

G

A

E

H

G

T

T

T

V

V

L

G

K

A

S

H

H

A

V

V

V

I

V

D

N

G

G

W

H

T

T

E

K

I

I

G

G

E

R

E

D

N

N

R

E

I

I

F

Y

P

Q

G

F

A

A

A

S

I

I

G

G

L

E

E

V

S

N

Q

Q

D
|
D

K
x
L

K
|
K

T

Y

D

A

G

G

S

E

L

P

S

T

V

R

V

V

R

E

I

I

G

G

D

D

R

R

N

N

R

R

I

I

R

R

E

E

Y

S

V

V

T

T

I

I

N

H

R

R

A

G

T

T

-

V

K

Q

A

G

G

G

E

G

A

L

T

T

V

K

I

V

G

G

N

S

D

D

N

N

L

L

M

M

A

I

Y

N

V

A

H

H

V

I

A

A

H
|
H

N
x
D

C

C

I

T

L

V

H

G

N

N

R

R

I

C

V

I

I

L

S

A

N

N

A

N

V

A

S

T

L

L

A

A

G
|
G

H
|
H

I

V

V

S

V

V

E

D

S

D

G

F

A

A

V

I

I

I

G

G

M

M

S

T

G

A

L

V

H

H

Q
|
Q

F

F

V

C

H

I

V

I

G

G

R

A

N

H

A

V

M

M

I

V

G

G

M

C

S

S

R

G

V

V

E

A

R

Q

D

D

V

V

P

P

Y

Y

M

V

L

I

V

A

E

Q

G

G

N

N

P

H

A

A

R

T

V

P

R

F

S

G

L

V

N

N

L

I

V

E

G

G

L

L

E

K

R

R

A

R

G

G

L

F

R

S

D

R

G

-

Q

-

E

-

G

-

E

E

A

A

F

I

K

T

Q

A

L

I

K

R

Q

N

A

A

Y

Y

R

K

L

L

L

I

Y

Y

R

R

S

S

D

G

L

K

L

T

L

L

K

D

E

E

A

V

I

K

A

P

E

E

I

I

R

A

Q

E

I

L

S

A

D

E

active site: H125 (= H121), D126 (≠ N122), G143 (= G139)
binding uridine-diphosphate-n-acetylglucosamine: D74 (= D71), L75 (≠ K72), K76 (= K73), H125 (= H121), H144 (= H140), Q161 (= Q157)

2aq9A Structure of e. Coli lpxa with a bound peptide that is competitive with acyl-acp (see paper)
45% identity, 90% coverage: 2:241/268 of query aligns to 5:241/262 of 2aq9A

query
sites
2aq9A

S

S

A

A

V

F

I

V

H

H

P

P

T

T

A

A

I

I

I

V

A

E

P

E

G

G

A

A

E

S

I

I

H

G

P

A

S

N

V

A

Q

H

I

I

G

G

P

P

Y

F

A

C

V

I

I

V

G

G

E

P

H

H

V

V

R

E

I

I

G

G

A

E

H

G

T

T

T

V

V

L

G

K

A

S

H

H

A

V

V

V

I

V

D

N

G

G

W

H

T

T

E

K

I

I

G

G

E

R

E

D

N

N

R

E

I

I

F

Y

P

Q

G

F

A

A

A

S

I

I

G

G

L

E

E

V

S

N

Q

Q

D

D

K

L

K

K

T

Y

D

A

G

G

S

E

L

P

S

T

V

R

V

V

R

E

I

I

G

G

D

D

R

R

N

N

R

R

I

I

R

R

E

E

Y

S

V

V

T

T

I

I

N

H

R

R

A

G

T

T

-

V

K

Q

A

G

G

G

E

G

A

L

T

T

V

K

I

V

G

G

N

S

D

D

N

N

L

L

M

M

A

I

Y

N

V

A

H

H

V

I

A

A

H
|
H

N
x
D

C

C

I

T

L

V

H

G

N

N

R

R

I

C

V

I

I

L

S

A

N

N

A

N

V

A

S

T

L

L

A

A

G
|
G

H

H

I

V

V

S

V

V

E

D

S

D

G

F

A

A

V

I

I

I

G

G

M

M

S

T

G

A

L

V

H
|
H

Q
|
Q

F

F

V

C

H

I

V

I

G

G

R

A

N

H

A

V

M

M

I

V

G

G

M

C

S

S

R

G

V

V

E

A

R

Q

D

D

V

V

P

P

Y

Y

M

V

L

I

V

A

E

Q

G

G

N

N

P

H

A

A

R

T

V

P

R

F

S

G

L

V

N

N

L

I

V

E

G

G

L

L

E

K

R

R

A

R

G

G

L

F

R

S

D

R

G

-

Q

-

E

-

G

-

E

E

A

A

F

I

K

T

Q

A

L

I

K

R

Q

N

A

A

Y

Y

R

K

L

L

L

I

Y

Y

R

R

S

S

D

G

L

K

L

T

L

L

K

D

E

E

A

V

I

K

A

P

E

E

I

I

R

A

Q

E

I

L

S

A

D

E

active site: H125 (= H121), D126 (≠ N122), G143 (= G139)
binding : H160 (= H156), Q161 (= Q157)

Sites not aligning to the query:

binding : 258

7okcA Crystal structure of escherichia coli lpxa in complex with compound 1 (see paper)
45% identity, 90% coverage: 2:241/268 of query aligns to 7:243/264 of 7okcA

query
sites
7okcA

S

S

A

A

V

F

I

V

H

H

P

P

T

T

A

A

I

I

I

V

A

E

P

E

G

G

A

A

E

S

I

I

H

G

P

A

S

N

V

A

Q

H

I

I

G

G

P

P

Y

F

A

C

V

I

I

V

G

G

E

P

H

H

V

V

R

E

I

I

G

G

A

E

H

G

T

T

T

V

V

L

G

K

A

S

H

H

A

V

V

V

I

V

D

N

G

G

W

H

T

T

E

K

I

I

G

G

E

R

E

D

N

N

R

E

I

I

F

Y

P

Q

G

F

A

A

A

S

I

I

G

G

L

E

E

V

S

N

Q

Q

D

D

K

L

K

K

T

Y

D

A

G

G

S

E

L

P

S

T

V

R

V

V

R

E

I

I

G

G

D

D

R

R

N

N

R

R

I

I

R

R

E

E

Y

S

V

V

T

T

I

I

N

H

R

R

A

G

T

T

-

V

K

Q

A

G

G

G

E

G

A

L

T

T

V

K

I

V

G

G

N

S

D

D

N

N

L

L

M

M

A

I

Y

N

V

A

H

H

V

I

A

A

H

H

N

D

C

C

I

T

L

V

H

G

N

N

R

R

I

C

V
x
I

I

L

S

A

N
|
N

A

N

V

A

S

T

L

L

A

A

G

G

H

H

I

V

V

S

V

V

E

D

S

D

G

F

A

A

V
x
I

I

I

G
|
G

M

M

S

T

G

A

L

V

H

H

Q

Q

F

F

V

C

H

I

V

I

G

G

R

A

N

H

A

V

M

M

I

V

G

G

G
|
G

M

C

S

S

R

G

V

V

E

A

R

Q

D

D

V

V

P

P

Y

Y

M

V

L

I

V

A

E

Q

G

G

N

N

P

H

A

A

R

T

V

P

R

F

S

G

L

V

N

N

L

I

V

E

G

G

L

L

E

K

R

R

A

R

G

G

L

F

R

S

D

R

G

-

Q

-

E

-

G

-

E

E

A

A

F

I

K

T

Q

A

L

I

K

R

Q

N

A

A

Y

Y

R

K

L

L

L

I

Y

Y

R

R

S

S

D

G

L

K

L

T

L

L

K

D

E

E

A

V

I

K

A

P

E

E

I

I

R

A

Q

E

I

L

S

A

D

E

binding 2-[2-(2-chlorophenyl)sulfanylethanoyl-[[4-(1,2,4-triazol-1-yl)phenyl]methyl]amino]-N-methyl-ethanamide: I136 (≠ V130), N139 (= N133), I154 (≠ V148), G156 (= G150), G157 (= G151), G175 (= G169)

3i3xA Structural basis for the sugar nucleotide and acyl chain selectivity of leptospira interrogans lpxa (see paper)
40% identity, 94% coverage: 5:256/268 of query aligns to 3:252/259 of 3i3xA

query
sites
3i3xA

I

I

H

H

P

P

T

T

A

A

I

I

A

D

P

P

G

K

A

A

E

E

I

L

H

H

P

E

S

S

V

V

Q

E

I

V

G

G

P

P

Y

Y

A

S

V

I

I

I

G

E

E

G

H

N

V

V

R

S

I

I

G

Q

A

E

H

G

T

T

T

I

V

I

G

E

A

G

H

H

A

V

V

K

I

I

D

C

G

A

W

G

T

S

E

E

I

I

G

G

E

K

E

F

N

N

R

R

I

F

F

H

P

Q

G

G

A

A

A

V

I

I

G

G

L

V

E

M

S

P

Q
|
Q

D

D

K

L

K

G

T

F

D

N

G

Q

S

Q

L

L

-

L

S

T

V

K

V

T

R

V

I

I

G

G

D

D

R

H

N

N

R

I

I

F

R

R

E

E

Y

Y

V

S

T

N

I

I

N

H

R

K

A

G

T

T

K

K

A

E

G

D

E

S

A

P

T

T

V

V

I

I

G

G

N

N

D

K

N

N

L

Y

L

F

M

M

A

G

Y

N

V

S

H
|
H

V

V

A

G

H
|
H

N
x
D

C

C

I

I

L

L

H

G

N

N

R

N

I

N

V

I

I

L

S

T

N

H

A

G

V

A

S

V

L

L

A
|
A

G
|
G

H

H

I

V

V

T

V

L

E

G

S

N

G

F

A

A

V

F

I

I

G

S

G

G

M

L

S

V

G

A

L

V

H
|
H

Q
|
Q

F
|
F

V

C

H

F

V

V

G

G

R

D

N

Y

A

S

M

M

I

V

G

A

G

G

M

L

S

A

R
x
K

V

V

E

V

R

Q

D

D

V

V

P

P

Y

Y

M

S

L

T

V

V

E

D

G

G

N

N

P

P

A

S

R

T

V

V

R

V

S

G

L

L

N

N

L

S

V

V

G

G

L

M

E

K

R

R

A

A

G

G

L

F

R

S

D

P

G

-

Q

-

E

-

G

-

E

E

A

V

F

R

K

N

Q

A

L

I

K

K

Q

H

A

A

Y

Y

R

K

L

V

L

I

Y

Y

R

H

S

S

D

G

L

I

L

S

L

T

K

R

E

K

A

A

I

L

A

D

E

E

I

L

R

E

Q

A

I

S

S

G

D

N

L

L

-

I

E

E

H

Q

L

V

Q

K

H

Y

L

I

C

I

N

K

F

F

L

F

E

R

A

D

S

S

Q

D

active site: H120 (= H121), D121 (≠ N122), G138 (= G139)
binding uridine-5'-diphosphate-3-N-(R-3-hydroxylauroyl)-N-acetyl-D-glucosamine: Q68 (= Q70), H117 (= H118), H120 (= H121), A137 (= A138), G138 (= G139), H155 (= H156), Q156 (= Q157), F157 (= F158), K171 (≠ R172)

3i3aA Structural basis for the sugar nucleotide and acyl chain selectivity of leptospira interrogans lpxa (see paper)
40% identity, 94% coverage: 5:256/268 of query aligns to 3:252/259 of 3i3aA

query
sites
3i3aA

I

I

H

H

P

P

T

T

A

A

I

I

A

D

P

P

G

K

A

A

E

E

I

L

H

H

P

E

S

S

V

V

Q

E

I

V

G

G

P

P

Y

Y

A

S

V

I

I

I

G

E

E

G

H

N

V

V

R

S

I

I

G

Q

A

E

H

G

T

T

T

I

V

I

G

E

A

G

H

H

A

V

V

K

I

I

D

C

G

A

W

G

T

S

E

E

I

I

G

G

E

K

E

F

N

N

R

R

I

F

F

H

P

Q

G

G

A

A

A

V

I

I

G

G

L

V

E

M

S

P

Q
|
Q

D

D

K

L

K

G

T

F

D

N

G

Q

S

Q

L

L

-

L

S

T

V

K

V

T

R

V

I

I

G

G

D

D

R

H

N

N

R

I

I

F

R

R

E

E

Y

Y

V

S

T

N

I

I

N

H

R

K

A

G

T

T

K

K

A

E

G

D

E

S

A

P

T

T

V

V

I

I

G

G

N

N

D

K

N

N

L

Y

L

F

M

M

A

G

Y

N

V

S

H
|
H

V

V

A

G

H
|
H

N
x
D

C

C

I

I

L

L

H

G

N

N

R

N

I

N

V

I

I

L

S

T

N

H

A

G

V

A

S

V

L

L

A
|
A

G
|
G

H

H

I

V

V

T

V

L

E

G

S

N

G

F

A

A

V

F

I

I

G

S

G

G

M

L

S

V

G

A

L

V

H
|
H

Q
|
Q

F

F

V

C

H

F

V

V

G

G

R

D

N

Y

A

S

M

M

I

V

G

A

G

G

M

L

S

A

R

K

V

V

E

V

R

Q

D

D

V

V

P

P

Y

Y

M

S

L

T

V

V

E

D

G

G

N

N

P

P

A

S

R

T

V

V

R

V

S

G

L

L

N

N

L

S

V

V

G

G

L

M

E

K

R

R

A

A

G

G

L

F

R

S

D

P

G

-

Q

-

E

-

G

-

E

E

A

V

F

R

K

N

Q

A

L

I

K

K

Q

H

A

A

Y

Y

R

K

L

V

L

I

Y

Y

R

H

S

S

D

G

L

I

L

S

L

T

K

R

E

K

A

A

I

L

A

D

E

E

I

L

R

E

Q

A

I

S

S

G

D

N

L

L

-

I

E

E

H

Q

L

V

Q

K

H

Y

L

I

C

I

N

K

F

F

L

F

E

R

A

D

S

S

Q

D

active site: H120 (= H121), D121 (≠ N122), G138 (= G139)
binding S-[2-({N-[(2R)-2-hydroxy-4-{[(S)-hydroxy(methoxy)phosphoryl]oxy}-3,3-dimethylbutanoyl]-beta-alanyl}amino)ethyl] (3R)-3-hydroxydodecanethioate: Q68 (= Q70), H117 (= H118), A137 (= A138), H155 (= H156), Q156 (= Q157)

Sites not aligning to the query:

binding S-[2-({N-[(2R)-2-hydroxy-4-{[(S)-hydroxy(methoxy)phosphoryl]oxy}-3,3-dimethylbutanoyl]-beta-alanyl}amino)ethyl] (3R)-3-hydroxydodecanethioate: 253

7t61A P. Aeruginosa lpxa in complex with ligand l15 (see paper)
40% identity, 83% coverage: 3:224/268 of query aligns to 1:219/257 of 7t61A

query
sites
7t61A

A

S

V

L

I

I

H

D

P

P

T

R

A

A

I

I

A

D

P

P

G

S

A

A

E

R

I

L

H

A

P

A

S

D

V

V

Q

Q

I

V

G

G

P

P

Y

W

A

S

V

I

I

V

G

G

E

A

H

E

V

V

R

E

I

I

G

G

A

E

H

G

T

T

T

V

V

I

G

G

A

P

H

H

A

V

V

V

I

L

D

K

G

G

W

P

T

T

E

K

I

I

G

G

E

K

E

H

N

N

R

R

I

I

F

Y

P

Q

G

F

A

S

I

V

G

G

L

E

E

D

S

T

Q

P

D
|
D

K

L

K

K

T

Y

D

K

G

G

S

E

L

P

S

T

V

R

V

L

R

V

I

I

G

G

D

D

R

H

N

N

R

V

I

I

R

R

E

E

Y

G

V

V

T

T

I

I

N

H

R

R

A

G

T

T

K

V

A

Q

G

D

E

R

A

A

-

E

T

T

V

T

I

I

G

G

N

D

D

H

N

N

L

L

L

I

M

M

A

A

Y

Y

V

A

H

H

V

I

A

G

H

H

N

D

C

S

I

V

L

I

H

G

N

N

R

H

I

C

V

I

I

L

S
x
V

N
|
N

A

N

V

T

S
x
A

L

L

A
|
A

G

G

H

H

I

V

V

H

V

V

E

D

S

D

G

W

A

A

V

I

I

L

G
x
S

G

G

M

Y

S

T

G

L

L

V

H
|
H

Q
|
Q

F
x
Y

V

C

H

R

V

I

G

G

R

A

N

H

A

S

M
x
F

I

S

G

G

G
x
M

M

G

S

S

R

A

V

I

E

G

R

K

D

D

V

V

P

P

P

A

Y

Y

M

V

L

T

V

V

E

F

G

G

N

N

P

P

A

A

R

E

V

A

R

R

S

S

L

M

N

N

L

F

V

E

G

G

L

M

E

R

R

R

A

R

G

G

L

F

R

-

D

-

G

-

Q

-

E

S

G

S

E

E

A

A

F

I

K

H

Q

A

L

L

K

R

Q

R

A

A

Y

Y

R

K

L

V

Y

Y

R

R

binding (3S)-3-({[(Z)-phenylmethylidene]carbamoyl}amino)-N-(1H-tetrazol-5-yl)-1-[3-(trifluoromethyl)benzoyl]-2,3-dihydro-1H-indole-3-carboxamide: D69 (= D71), V131 (≠ S132), N132 (= N133), A135 (≠ S136), A137 (= A138), S149 (≠ G150), H155 (= H156), Q156 (= Q157), Y157 (≠ F158), F165 (≠ M166), M168 (≠ G169)

7t60A P. Aeruginosa lpxa in complex with ligand l13 (see paper)
40% identity, 83% coverage: 3:224/268 of query aligns to 1:219/257 of 7t60A

query
sites
7t60A

A

S

V

L

I

I

H

D

P

P

T

R

A

A

I

I

A

D

P

P

G

S

A

A

E

R

I

L

H

A

P

A

S

D

V

V

Q

Q

I

V

G

G

P

P

Y

W

A

S

V

I

I

V

G

G

E

A

H

E

V

V

R

E

I

I

G

G

A

E

H

G

T

T

T

V

V

I

G

G

A

P

H

H

A

V

V

V

I

L

D

K

G

G

W

P

T

T

E

K

I

I

G

G

E

K

E

H

N

N

R

R

I

I

F

Y

P

Q

G

F

A

S

I

V

G

G

L

E

E

D

S

T

Q

P

D

D

K

L

K

K

T

Y

D

K

G

G

S

E

L

P

S

T

V

R

V

L

R

V

I

I

G

G

D

D

R

H

N

N

R

V

I

I

R

R

E

E

Y

G

V

V

T

T

I

I

N

H

R

R

A

G

T

T

K

V

A

Q

G

D

E

R

A

A

-

E

T

T

V

T

I

I

G

G

N

D

D

H

N

N

L

L

L

I

M
|
M

A

A

Y

Y

V

A

H
|
H

V

I

A

G

H

H

N

D

C

S

I

V

L

I

H

G

N

N

R

H

I

C

V

I

I

L

S
x
V

N
|
N

A

N

V

T

S

A

L

L

A

A

G

G

H

H

I

V

V

H

V

V

E

D

S

D

G

W

A

A

V

I

I

L

G
x
S

G

G

M

Y

S

T

G

L

L

V

H
|
H

Q
|
Q

F

Y

V

C

H

R

V

I

G

G

R

A

N

H

A

S

M

F

I

S

G
|
G

G
x
M

M

G

S

S

R

A

V

I

E

G

R

K

D

D

V

V

P

P

P

A

Y

Y

M

V

L

T

V

V

E

F

G

G

N

N

P

P

A

A

R

E

V

A

R

R

S

S

L

M

N

N

L

F

V

E

G

G

L

M

E

R

R

R

A

R

G

G

L

F

R

-

D

-

G

-

Q

-

E

S

G

S

E

E

A

A

F

I

K

H

Q

A

L

L

K

R

Q

R

A

A

Y

Y

R

K

L

V

Y

Y

R

R

binding (3S)-3-(5,5-dimethyl-2-oxo-1,3-oxazolidin-3-yl)-N-(1H-tetrazol-5-yl)-1-[3-(trifluoromethyl)benzoyl]-2,3-dihydro-1H-indole-3-carboxamide: M113 (= M114), H117 (= H118), V131 (≠ S132), N132 (= N133), S149 (≠ G150), H155 (= H156), Q156 (= Q157), G167 (= G168), M168 (≠ G169)

7t5zA P. Aeruginosa lpxa in complex with ligand l8 (see paper)
40% identity, 83% coverage: 3:224/268 of query aligns to 1:219/257 of 7t5zA

query
sites
7t5zA

A

S

V

L

I

I

H

D

P

P

T

R

A

A

I

I

A

D

P

P

G

S

A

A

E

R

I

L

H

A

P

A

S

D

V

V

Q

Q

I

V

G

G

P

P

Y

W

A

S

V

I

I

V

G

G

E

A

H

E

V

V

R

E

I

I

G

G

A

E

H

G

T

T

T

V

V

I

G

G

A

P

H

H

A

V

V

V

I

L

D

K

G

G

W

P

T

T

E

K

I

I

G

G

E

K

E

H

N

N

R

R

I

I

F

Y

P

Q

G

F

A

S

I

V

G

G

L

E

E

D

S

T

Q

P

D

D

K

L

K

K

T

Y

D

K

G

G

S

E

L

P

S

T

V

R

V

L

R

V

I

I

G

G

D

D

R

H

N

N

R

V

I

I

R

R

E

E

Y

G

V

V

T

T

I

I

N

H

R

R

A

G

T

T

K

V

A

Q

G

D

E

R

A

A

-

E

T

T

V

T

I

I

G

G

N

D

D

H

N

N

L

L

L

I

M

M

A

A

Y

Y

V

A

H

H

V

I

A

G

H

H

N

D

C

S

I

V

L

I

H

G

N

N

R

H

I

C

V

I

I

L

S
x
V

N
|
N

A

N

V

T

S
x
A

L

L

A
|
A

G

G

H

H

I

V

V

H

V

V

E

D

S

D

G

W

A

A

V

I

I

L

G
x
S

G

G

M

Y

S

T

G

L

L

V

H
|
H

Q

Q

F

Y

V

C

H

R

V

I

G

G

R

A

N

H

A

S

M
x
F

I

S

G

G

G

M

M

G

S

S

R

A

V

I

E

G

R

K

D

D

V

V

P

P

P

A

Y

Y

M

V

L

T

V

V

E

F

G

G

N

N

P

P

A

A

R

E

V

A

R

R

S

S

L

M

N

N

L

F

V

E

G

G

L

M

E

R

R

R

A

R

G

G

L

F

R

-

D

-

G

-

Q

-

E

S

G

S

E

E

A

A

F

I

K

H

Q

A

L

L

K

R

Q

R

A

A

Y

Y

R

K

L

V

Y

Y

R

R

binding (4S)-N-(1H-tetrazol-5-yl)-2-[3-(trifluoromethyl)benzene-1-sulfonyl]-1,2,3,4-tetrahydroisoquinoline-4-carboxamide: V131 (≠ S132), N132 (= N133), A135 (≠ S136), A137 (= A138), S149 (≠ G150), H155 (= H156), F165 (≠ M166)

7t5xA P. Aeruginosa lpxa in complex with ligand l6 (see paper)
40% identity, 83% coverage: 3:224/268 of query aligns to 1:219/257 of 7t5xA

query
sites
7t5xA

A

S

V

L

I

I

H

D

P

P

T

R

A

A

I

I

A

D

P

P

G

S

A

A

E

R

I

L

H

A

P

A

S

D

V

V

Q

Q

I

V

G

G

P

P

Y

W

A

S

V

I

I

V

G

G

E

A

H

E

V

V

R

E

I

I

G

G

A

E

H

G

T

T

T

V

V

I

G

G

A

P

H

H

A

V

V

V

I

L

D

K

G

G

W

P

T

T

E

K

I

I

G

G

E

K

E

H

N

N

R

R

I

I

F

Y

P

Q

G

F

A

S

I

V

G

G

L

E

E

D

S

T

Q

P

D

D

K

L

K

K

T

Y

D

K

G

G

S

E

L

P

S

T

V

R

V

L

R

V

I

I

G

G

D

D

R

H

N

N

R

V

I

I

R

R

E

E

Y

G

V

V

T

T

I

I

N

H

R

R

A

G

T

T

K

V

A

Q

G

D

E

R

A

A

-

E

T

T

V

T

I

I

G

G

N

D

D

H

N

N

L

L

L

I

M

M

A

A

Y

Y

V

A

H

H

V

I

A

G

H

H

N

D

C

S

I

V

L

I

H

G

N

N

R

H

I

C

V

I

I

L

S
x
V

N

N

A

N

V

T

S

A

L

L

A
|
A

G

G

H

H

I

V

V

H

V

V

E

D

S

D

G

W

A

A

V

I

I

L

G
x
S

G
|
G

M

Y

S

T

G

L

L

V

H
|
H

Q

Q

F

Y

V

C

H

R

V

I

G

G

R

A

N

H

A

S

M
x
F

I

S

G
|
G

G
x
M

M

G

S

S

R

A

V

I

E

G

R

K

D

D

V

V

P

P

P

A

Y

Y

M

V

L

T

V

V

E

F

G

G

N

N

P

P

A

A

R

E

V

A

R

R

S

S

L

M

N

N

L

F

V

E

G

G

L

M

E

R

R

R

A

R

G

G

L

F

R

-

D

-

G

-

Q

-

E

S

G

S

E

E

A

A

F

I

K

H

Q

A

L

L

K

R

Q

R

A

A

Y

Y

R

K

L

V

Y

Y

R

R

binding Nalpha-(tert-butoxycarbonyl)-N-1H-tetrazol-5-yl-D-tryptophanamide: V131 (≠ S132), A137 (= A138), S149 (≠ G150), G150 (= G151), H155 (= H156), F165 (≠ M166), G167 (= G168), M168 (≠ G169)

7t5sA P. Aeruginosa lpxa in complex with ligand h16 (see paper)
40% identity, 83% coverage: 3:224/268 of query aligns to 1:219/257 of 7t5sA

query
sites
7t5sA

A

S

V

L

I

I

H

D

P

P

T

R

A

A

I

I

A

D

P

P

G

S

A

A

E

R

I

L

H

A

P

A

S

D

V

V

Q

Q

I

V

G

G

P

P

Y

W

A

S

V

I

I

V

G

G

E

A

H

E

V

V

R

E

I

I

G

G

A

E

H

G

T

T

T

V

V

I

G

G

A

P

H

H

A

V

V

V

I

L

D

K

G

G

W

P

T

T

E

K

I

I

G

G

E

K

E

H

N

N

R

R

I

I

F

Y

P

Q

G

F

A

S

I

V

G

G

L

E

E

D

S

T

Q

P

D

D

K

L

K

K

T

Y

D

K

G

G

S

E

L

P

S

T

V

R

V

L

R

V

I

I

G

G

D

D

R

H

N

N

R

V

I

I

R

R

E

E

Y

G

V

V

T

T

I

I

N

H

R

R

A

G

T

T

K

V

A

Q

G

D

E

R

A

A

-

E

T

T

V

T

I

I

G

G

N

D

D

H

N

N

L

L

L

I

M

M

A

A

Y

Y

V

A

H

H

V

I

A

G

H

H

N

D

C

S

I

V

L

I

H

G

N

N

R

H

I

C

V

I

I

L

S
x
V

N

N

A

N

V

T

S
x
A

L

L

A
|
A

G

G

H

H

I

V

V

H

V

V

E

D

S

D

G

W

A

A

V

I

I

L

G
x
S

G
|
G

M

Y

S

T

G

L

L

V

H
|
H

Q

Q

F

Y

V

C

H

R

V

I

G

G

R

A

N

H

A

S

M
x
F

I

S

G

G

G
x
M

M

G

S

S

R

A

V

I

E

G

R

K

D

D

V

V

P

P

P

A

Y

Y

M

V

L

T

V

V

E

F

G

G

N

N

P

P

A

A

R

E

V

A

R

R

S

S

L

M

N

N

L

F

V

E

G

G

L

M

E

R

R

R

A

R

G

G

L

F

R

-

D

-

G

-

Q

-

E

S

G

S

E

E

A

A

F

I

K

H

Q

A

L

L

K

R

Q

R

A

A

Y

Y

R

K

L

V

Y

Y

R

R

binding N~2~-(cyclohexylacetyl)-N-1H-tetrazol-5-yl-L-alaninamide: V131 (≠ S132), A135 (≠ S136), A137 (= A138), S149 (≠ G150), G150 (= G151), H155 (= H156), F165 (≠ M166), M168 (≠ G169)

7t5rA P. Aeruginosa lpxa in complex with ligand h7 (see paper)
40% identity, 83% coverage: 3:224/268 of query aligns to 1:219/257 of 7t5rA

query
sites
7t5rA

A

S

V

L

I

I

H

D

P

P

T

R

A

A

I

I

A

D

P

P

G

S

A

A

E

R

I

L

H

A

P

A

S

D

V

V

Q

Q

I

V

G

G

P

P

Y

W

A

S

V

I

I

V

G

G

E

A

H

E

V

V

R

E

I

I

G

G

A

E

H

G

T

T

T

V

V

I

G

G

A

P

H

H

A

V

V

V

I

L

D

K

G

G

W

P

T

T

E

K

I

I

G

G

E

K

E

H

N

N

R

R

I

I

F

Y

P

Q

G

F

A

S

I

V

G

G

L

E

E

D

S

T

Q

P

D

D

K

L

K

K

T

Y

D

K

G

G

S

E

L

P

S

T

V

R

V

L

R

V

I

I

G

G

D

D

R

H

N

N

R

V

I

I

R

R

E

E

Y

G

V

V

T

T

I

I

N

H

R

R

A

G

T

T

K

V

A

Q

G

D

E

R

A

A

-

E

T

T

V

T

I

I

G

G

N

D

D

H

N

N

L

L

L

I

M

M

A

A

Y

Y

V

A

H

H

V

I

A

G

H

H

N

D

C

S

I

V

L

I

H

G

N

N

R

H

I

C

V

I

I

L

S
x
V

N
|
N

A

N

V

T

S

A

L

L

A
|
A

G

G

H

H

I

V

V

H

V

V

E

D

S

D

G

W

A

A

V

I

I

L

G

S

G

G

M

Y

S

T

G

L

L

V

H
|
H

Q

Q

F

Y

V

C

H

R

V

I

G

G

R

A

N

H

A

S

M
x
F

I

S

G
|
G

G
x
M

M

G

S

S

R

A

V

I

E

G

R

K

D

D

V

V

P

P

P

A

Y

Y

M

V

L

T

V

V

E
x
F

G

G

N

N

P

P

A

A

R

E

V

A

R

R

S

S

L

M

N

N

L

F

V

E

G

G

L

M

E

R

R

R

A

R

G

G

L

F

R

-

D

-

G

-

Q

-

E

S

G

S

E

E

A

A

F

I

K

H

Q

A

L

L

K

R

Q

R

A

A

Y

Y

R

K

L

V

Y

Y

R

R

binding 3-bromo-N-[3-(1H-tetrazol-5-yl)phenyl]-1H-indole-5-carboxamide: V131 (≠ S132), N132 (= N133), A137 (= A138), H155 (= H156), F165 (≠ M166), G167 (= G168), M168 (≠ G169), F183 (≠ E184)

7okbA Crystal structure of pseudomonas aeruginosa lpxa in complex with compound 45 (see paper)
40% identity, 83% coverage: 3:224/268 of query aligns to 2:220/258 of 7okbA

query
sites
7okbA

A

S

V

L

I

I

H

D

P

P

T

R

A

A

I

I

A

D

P

P

G

S

A

A

E

R

I

L

H

A

P

A

S

D

V

V

Q

Q

I

V

G

G

P

P

Y

W

A

S

V

I

I

V

G

G

E

A

H

E

V

V

R

E

I

I

G

G

A

E

H

G

T

T

T

V

V

I

G

G

A

P

H

H

A

V

V

V

I

L

D

K

G

G

W

P

T

T

E

K

I

I

G

G

E

K

E

H

N

N

R

R

I

I

F

Y

P

Q

G

F

A

S

I

V

G

G

L

E

E

D

S

T

Q

P

D

D

K

L

K

K

T

Y

D

K

G

G

S

E

L

P

S

T

V

R

V

L

R

V

I

I

G

G

D

D

R

H

N

N

R

V

I

I

R

R

E

E

Y

G

V

V

T

T

I

I

N

H

R

R

A

G

T

T

K

V

A

Q

G

D

E

R

A

A

-

E

T

T

V

T

I

I

G

G

N

D

D

H

N

N

L

L

L

I

M

M

A

A

Y

Y

V

A

H

H

V

I

A

G

H

H

N

D

C

S

I

V

L

I

H

G

N

N

R

H

I

C

V

I

I

L

S
x
V

N
|
N

A

N

V

T

S

A

L

L

A
|
A

G

G

H

H

I

V

V

H

V

V

E

D

S

D

G

W

A

A

V

I

I

L

G
x
S

G
|
G

M

Y

S

T

G

L

L

V

H
|
H

Q

Q

F

Y

V

C

H

R

V

I

G

G

R

A

N

H

A

S

M
x
F

I

S

G

G

G
x
M

M

G

S

S

R

A

V

I

E

G

R

K

D

D

V

V

P

P

P

A

Y

Y

M

V

L

T

V

V

E

F

G

G

N

N

P

P

A

A

R

E

V

A

R

R

S

S

L

M

N

N

L

F

V

E

G

G

L

M

E

R

R

R

A

R

G

G

L

F

R

-

D

-

G

-

Q

-

E

S

G

S

E

E

A

A

F

I

K

H

Q

A

L

L

K

R

Q

R

A

A

Y

Y

R

K

L

V

Y

Y

R

R

binding ~{N}-[(5-azanyl-1,3,4-oxadiazol-2-yl)methyl]-2-(2-chlorophenyl)sulfanyl-~{N}-[(6-oxidanylidene-1~{H}-pyridin-3-yl)methyl]ethanamide: V132 (≠ S132), N133 (= N133), A138 (= A138), S150 (≠ G150), G151 (= G151), H156 (= H156), F166 (≠ M166), M169 (≠ G169)

Query Sequence

>Synpcc7942_0931 Synpcc7942_0931 UDP-N-acetylglucosamine acyltransferase
VSAVIHPTAIIAPGAEIHPSVQIGPYAVIGEHVRIGAHTTVGAHAVIDGWTEIGEENRIF
PGAAIGLESQDKKTDGSLSVVRIGDRNRIREYVTINRATKAGEATVIGNDNLLMAYVHVA
HNCILHNRIVISNAVSLAGHIVVESGAVIGGMSGLHQFVHVGRNAMIGGMSRVERDVPPY
MLVEGNPARVRSLNLVGLERAGLRDGQEGEAFKQLKQAYRLLYRSDLLLKEAIAEIRQIS
DLEHLQHLCNFLEASQGSERRGPTPGSK

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory