SitesBLAST – Find functional sites

 

SitesBLAST

Comparing WP_011383005.1 NCBI__GCF_000009985.1:WP_011383005.1 to proteins with known functional sites using BLASTp with E ≤ 0.001.

Or try Sites on a Tree, PaperBLAST, Conserved Domains, or compare to all protein structures

Found 6 hits to proteins with known functional sites (download)

1dcpA Dcoh, a bifunctional protein-binding transcriptional coactivator, complexed with biopterin (see paper)
54% identity, 70% coverage: 35:126/132 of query aligns to 2:95/99 of 1dcpA

query
sites
1dcpA
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R
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L
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A
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E
E
 
E
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D
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P
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A

1f93A Crystal structure of a complex between the dimerization domain of hnf-1 alpha and the coactivator dcoh (see paper)
54% identity, 70% coverage: 35:126/132 of query aligns to 6:99/103 of 1f93A

query
sites
1f93A
R
 
R
L
 
L
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S
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A
S
 
E
E
 
E
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R
T
 
D
S
 
Q
A
 
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L
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P
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N
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A
 
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E
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A

P61459 Pterin-4-alpha-carbinolamine dehydratase; PHS; 4-alpha-hydroxy-tetrahydropterin dehydratase; Dimerization cofactor of hepatocyte nuclear factor 1-alpha; DCoH; Dimerization cofactor of HNF1; Phenylalanine hydroxylase-stimulating protein; Pterin carbinolamine dehydratase; PCD; EC 4.2.1.96 from Rattus norvegicus (Rat) (see 2 papers)
54% identity, 70% coverage: 35:126/132 of query aligns to 7:100/104 of P61459

query
sites
P61459
R
 
R
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L
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A
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E
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E
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D
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Sites not aligning to the query:

P61457 Pterin-4-alpha-carbinolamine dehydratase; PHS; 4-alpha-hydroxy-tetrahydropterin dehydratase; Dimerization cofactor of hepatocyte nuclear factor 1-alpha; DCoH; Dimerization cofactor of HNF1; Phenylalanine hydroxylase-stimulating protein; Pterin carbinolamine dehydratase; PCD; EC 4.2.1.96 from Homo sapiens (Human) (see 6 papers)
54% identity, 70% coverage: 35:126/132 of query aligns to 7:100/104 of P61457

query
sites
P61457
R
 
R
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L
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S
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E
E
 
E
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A

Sites not aligning to the query:

2v6tB Crystal structure of a complex of pterin-4a-carbinolamine dehydratase from toxoplasma gondii with 7,8-dihydrobiopterin (see paper)
48% identity, 58% coverage: 51:127/132 of query aligns to 21:97/100 of 2v6tB

query
sites
2v6tB
W
 
W
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H
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F
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A
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G
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F
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D
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A
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K

Q02I31 Putative pterin-4-alpha-carbinolamine dehydratase; PHS; 4-alpha-hydroxy-tetrahydropterin dehydratase; Pterin carbinolamine dehydratase; PCD; EC 4.2.1.96 from Pseudomonas aeruginosa (strain UCBPP-PA14) (see paper)
28% identity, 72% coverage: 36:130/132 of query aligns to 19:115/118 of Q02I31

query
sites
Q02I31
L
 
V
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S
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D
S
 
E
E
 
E
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L
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P
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L
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P
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D
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W
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N
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-
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I
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Y
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L
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N
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H
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A
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L
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A
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F
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T
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A
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P
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T
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K
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D
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A
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K
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A
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E

Sites not aligning to the query:

Query Sequence

>WP_011383005.1 NCBI__GCF_000009985.1:WP_011383005.1
MTLLMVRIYPVLAAGTRGPHSFDSTRQGDGKMIARLSGSERTSALAGLAGWTEVEGRDAI
SRSLRFADFSEAFAFMTRIAMAAERMNHHPEWFNVWNRVDITLSTHDVGGVTQKDISLAR
AIDAAASHASRT

Or try a new SitesBLAST search

SitesBLAST's Database

SitesBLAST's database includes (1) SwissProt entries with experimentally-supported functional features; and (2) protein structures with bound ligands, from the BioLip database.

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory