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Comment: BT2402 (red label) replaces homoserine kinase (thrB) in threonine biosynthesis, as do some similar proteins (green nodes). The phosphate donor is not known. These alternate homoserine kinases are related to cofactor-independent phosphoglycerate mutases (blue nodes). The binding sites for two zinc ions (in PDB 2zktB) are conserved, but not the binding site for calcium.

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BRENDA__A0A1D3TXG7: putative phosphoglycerate mutase [Anaerobium acetethylicum] BT2402: alternative homoserine kinase [Bacteroides thetaiotaomicron VPI-5482] HMPREF1058_RS14725: alternative homoserine kinase [Phocaeicola vulgatus CL09T03C04] SwissProt__O28523: phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent [Archaeoglobus fulgidus ATCC 49558] BRENDA__Q980A0: phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent [Saccharolobus solfataricus] SwissProt__Q59007: phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent [Methanocaldococcus jannaschii ATCC 43067] SwissProt__P58814: phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent [Pyrococcus furiosus ATCC 43587] biolip__2zktB: structure of phosphoglycerate mutase PH0037 [Pyrococcus horikoshii] 1.000 BRENDA__A0A1D3TXG7: putative phosphoglycerate mutase [Anaerobium acetethylicum] BRENDA__A0A1D3TXG7BRENDA__A0A1D3TXG7: putative phosphoglycerate mutase [Anaerobium acetethylicum] 1.000 BT2402: alternative homoserine kinase [Bacteroides thetaiotaomicron VPI-5482] BT2402BT2402: alternative homoserine kinase [Bacteroides thetaiotaomicron VPI-5482] HMPREF1058_RS14725: alternative homoserine kinase [Phocaeicola vulgatus CL09T03C04] HMPREF1058_RS14725HMPREF1058_RS14725: alternative homoserine kinase [Phocaeicola vulgatus CL09T03C04] 1.000 SwissProt__O28523: phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent [Archaeoglobus fulgidus ATCC 49558] SwissProt__O28523SwissProt__O28523: phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent [Archaeoglobus fulgidus ATCC 49558] 0.832 BRENDA__Q980A0: phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent [Saccharolobus solfataricus] BRENDA__Q980A0BRENDA__Q980A0: phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent [Saccharolobus solfataricus] 0.464 SwissProt__Q59007: phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent [Methanocaldococcus jannaschii ATCC 43067] SwissProt__Q59007SwissProt__Q59007: phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent [Methanocaldococcus jannaschii ATCC 43067] 1.000 SwissProt__P58814: phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent [Pyrococcus furiosus ATCC 43587] SwissProt__P58814SwissProt__P58814: phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent [Pyrococcus furiosus ATCC 43587] biolip__2zktB: structure of phosphoglycerate mutase PH0037 [Pyrococcus horikoshii] biolip__2zktBbiolip__2zktB: structure of phosphoglycerate mutase PH0037 [Pyrococcus horikoshii] BRENDA__A0A1D3TXG7: putative phosphoglycerate mutase [Anaerobium acetethylicum]BRENDA__A0A1D3TXG7 putative phosphoglycerate mutase [Anaerobium acetethylicum] BT2402: alternative homoserine kinase [Bacteroides thetaiotaomicron VPI-5482]BT2402 alternative homoserine kinase [Bacteroides thetaiotaomicron VPI-5482] HMPREF1058_RS14725: alternative homoserine kinase [Phocaeicola vulgatus CL09T03C04]HMPREF1058_RS14725 alternative homoserine kinase [Phocaeicola vulgatus CL09T03C04] SwissProt__O28523: phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent [Archaeoglobus fulgidus ATCC 49558]SwissProt__O28523 phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent [Archaeoglobus fulgidus ATCC 49558] BRENDA__Q980A0: phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent [Saccharolobus solfataricus]BRENDA__Q980A0 phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent [Saccharolobus solfataricus] SwissProt__Q59007: phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent [Methanocaldococcus jannaschii ATCC 43067]SwissProt__Q59007 phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent [Methanocaldococcus jannaschii ATCC 43067] SwissProt__P58814: phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent [Pyrococcus furiosus ATCC 43587]SwissProt__P58814 phosphoglycerate mutase, 2,3-bisphosphoglycerate-independent [Pyrococcus furiosus ATCC 43587] biolip__2zktB: structure of phosphoglycerate mutase PH0037 [Pyrococcus horikoshii]biolip__2zktB structure of phosphoglycerate mutase PH0037 [Pyrococcus horikoshii] 0.5 /site download SVG

by Morgan Price, Arkin group
Lawrence Berkeley National Laboratory