These 565 PFams are annotated as domains of unknown function, yet they contain at least one protein that has been curated and appears to be characterized. These families may be good targets for curation or for biochemical study.
For each family, we show up to 20 characterized representatives. (Characterized members are excluded if they contain other domains that are characterized.) We also show the annotation of the PFam in InterPro, because sometimes a DUF has a more specific annotation in InterPro. And we show the overlapping families (if any) from the Conserved Domains Database. DUFs with the most papers about them are shown first.
Last updated on Feb. 7, 2022
DUF3652 (PF12372.11): Huntingtin protein region (41 a.a.), 900 papers
IPR024613: Huntingtin_middle-repeat. This repeated domain is less than 40 amino acids in length and is associated with the huntingtin protein. The protein is of unknown function, however it is known that an expansion of a polyglutamine (CAG) repeat in the gene coding for it results in the development of Huntington's disease.
Overlapping families in CDD: HEAT
Members of DUF3652 whose function may be known:
UPF0020 (PF01170.21): Putative RNA methylase family UPF0020 (197 a.a.), 350 papers
IPR000241: RNA_methylase_dom. This domain is probably a methylase. It is associated with the THUMP domain that also occurs with RNA modification domains.
Overlapping families in CDD: RlmL, TIGR01177, Trm11
Members of UPF0020 whose function may be known:
DUF3399 (PF11879.11): Domain of unknown function (DUF3399) (77 a.a.), 242 papers
IPR024587: K_chnl_volt-dep_Kv4_C. The Kv family can be divided into several subfamilies on the basis of sequence similarity and function. Four of these subfamilies, Kv1 (Shaker), Kv2 (Shab), Kv3 (Shaw) and Kv4 (Shal), consist of pore-forming alpha subunits that associate with different types of beta subunit. Each alpha subunit comprises six hydrophobic TM domains with a P-domain between the fifth and sixth,...
Members of DUF3399 whose function may be known:
DUF676 (PF05057.17): Putative serine esterase (DUF676) (219 a.a.), 210 papers
IPR007751: DUF676_lipase-like. This domain, whose function is unknown, is found within a group of putative lipases. Proteins containing this domain include YOR059C (Lpl1) from budding yeasts. Lpl1 has been identified as a phospholipase B.
Members of DUF676 whose function may be known:
DUF758 (PF05527.14): Domain of unknown function (DUF758) (181 a.a.), 178 papers
IPR008477: TNFAIP8-like. Four tumor necrosis factor alpha-induced protein 8-like proteins have been identified: TNFAIP8 (also known as TIPE), TIPE1, TIPE2 and TIPE3. Overexpressed TIPE in cells can reduce cell death in vitro and increase tumor growth in vivo. By contrast, TIPE2 has been demonstrated to be an inhibitor of Ras and to have a pro-apoptotic ability. TIPE1 could upregulate the pro-apoptotic...
Members of DUF758 whose function may be known:
DUF1752 (PF08550.13): Fungal protein of unknown function (DUF1752) (28 a.a.), 164 papers
IPR013860: AreA_GATA. This entry represents fungal proteins containing GATA domains, including nitrogen regulatory protein areA, a transcription activator that binds the consensus DNA element 5'-CGATAG-3' and mediates nitrogen metabolite repression. The entry also contains that is thought to be a negative regulator of RAS-cAMP pathway in S. cerevisiae and the S. pombe member is a GAF1 transcription factor .
Members of DUF1752 whose function may be known:
SIMPL (PF04402.17): Protein of unknown function (DUF541) (197 a.a.), 145 papers
IPR007497: DUF541. Members of this family have been found in bacteria, archaea and animals. A mouse family member has been named SIMPL (signalling molecule that associates with mouse pelle-like kinase). SIMPL appears to facilitate and/or regulate complex formation between IRAK/mPLK (IL-1 receptor-associated kinase) and IKK (inhibitor of kappa-B kinase) containing complexes, and thus regulate NF-kappa-B activity. Separate experiments demonstrate that a...
Overlapping families in CDD: PRK11087, YggE
Members of SIMPL whose function may be known:
DUF6539 (PF20173.1): Family of unknown function (DUF6539) (54 a.a.), 140 papers
Overlapping families in CDD: AAA, PEX10, RING, RING-H2, RING-H2_DZIP3, RING-H2_RNF11, RING-HC, RING-HC_AtRMA_like, RING-HC_BARD1, RING-HC_HLTF, RING-HC_LNX3, RING-HC_LNX3_like, RING-HC_PEX10, RING-HC_RNF135_like, RING-HC_RNF141, RING-HC_RNF151, RING-HC_RNF170, RING-HC_RNF185, RING-HC_RNF207, RING-HC_RNF213, RING-HC_RNF219, RING-HC_RNF5, RING-HC_RNF5_like, RING-HC_RNFT1, RING-HC_RNFT1_like, RING-HC_RNFT2, RING-HC_TRIM13_like_C-V, RING-HC_TRIM40-C-V, RING-HC_TRIM47_C-IV, RING-HC_TRIM65_C-IV, RING-HC_TRIM7_C-IV, RING_Ubox, mRING-HC-C4C4_TRIM37_C-VIII
Members of DUF6539 whose function may be known:
DUF3456 (PF11938.11): TLR4 regulator and MIR-interacting MSAP (151 a.a.), 133 papers
IPR021852: DUF3456. This presumed domain is functionally uncharacterised. It is found in a number of proteins, including protein canopy homologues and CRELD1 and 2.
Members of DUF3456 whose function may be known:
DUF4939 (PF16297.8): Domain of unknown function (DUF4939) (112 a.a.), 121 papers
IPR032549: DUF4939. This domain is found in some members of the Mart (mammalian retrotransposon-derived) family, including LDOC1/Mart7, LDOC1L/Mart6, RTL1/Mart1, PEG10/Mart2, FAM127/Cxx1/Mart8, ZCCHC5/Mart3 and RGAG4/Mart5. Its function is not known.
Overlapping families in CDD: PHA03247, PRK07994, PRK12323, PTZ00449, pneumo_PspA
Members of DUF4939 whose function may be known:
DUF4174 (PF13778.9): Domain of unknown function (DUF4174) (120 a.a.), 120 papers
IPR025232: DUF4174. This domain of unknown function is found in a putative tumour suppressor gene and in a ligand for the the urokinase-type plasminogen activator receptor, which plays a role in cellular migration and adhesion.
Overlapping families in CDD: PHA03247, PRK07003, PRK12323, PTZ00449, gliding_GltJ
Members of DUF4174 whose function may be known:
DUF732 (PF05305.17): Protein of unknown function (DUF732) (72 a.a.), 115 papers
IPR007969: DUF732. This entry represents several uncharacterised Mycobacterium tuberculosis proteins of unknown function.
Members of DUF732 whose function may be known:
DUF1241 (PF06840.14): Protein of unknown function (DUF1241) (150 a.a.), 110 papers
Members of DUF1241 whose function may be known:
DUF218 (PF02698.20): DUF218 domain (130 a.a.), 108 papers
IPR003848: DUF218. This domain contains several highly conserved charged amino acids, suggesting this may be an enzymatic domain. It is found in Escherichia coli YdcF, which has been shown to bind S-adenosyl-L-methionine (AdoMet), but whose biochemical function has not been identified. It is also found in Escherichia coli SanA and Salmonella typhimurium SfiX, which are involved in vancomycin resistance. SfiX may...
Overlapping families in CDD: PRK10494, PRK10834, SanA, YdcF, YdcF-like
Members of DUF218 whose function may be known:
DUF3298 (PF11738.11): Protein of unknown function (DUF3298) (84 a.a.), 105 papers
IPR021729: DUF3298. This entry represents a highly conserved domain found in a group of bacterial proteins. The function of this domain is not known. Proteins containing this domain include pdaC and anti-sigma-V factor RsiV from Bacillus subtilis. PdaC catalyzes the deacetylation of N-acetylmuramic acid (MurNAc) residues in peptidoglycan, a modification that confers resistance to lysosyme.
Members of DUF3298 whose function may be known:
UPF0016 (PF01169.22): Uncharacterized protein family UPF0016 (75 a.a.), 97 papers
IPR001727: Gdt1. Budding yeast Gdt1 is a Golgi-localized calcium transporter required for stress-induced calcium signalling and protein glycosylation. Its human homologue, TMEM165, may be a Golgi Ca2(+)/H(+) antiporter. Defects in the human protein TMEM165 cause a subtype of Congenital Disorders of Glycosylation. In Arabidopsis , this protein is variously known as CCHA1 (a chloroplast-localized potential Ca(2+)/H(+) antiporter), chloroplastic PAM71 (photosynthesis affected...
Overlapping families in CDD: Gdt1
Members of UPF0016 whose function may be known:
PGG (PF13962.9): Domain of unknown function (116 a.a.), 97 papers
IPR026961: PGG_dom. The PGG domain is named for the highly conserved sequence motif found at the start of the domain. Its function is not known.
Members of PGG whose function may be known:
DUF308 (PF03729.16): Short repeat of unknown function (DUF308) (73 a.a.), 92 papers
IPR005325: DUF308_memb. This represents a group of short repeats that occurs in a limited number of membrane proteins. It may divide further in short repeats of around 7-10 residues of the pattern G-#-X(2)-#(2)-X (#=hydrophobic).
Overlapping families in CDD: HdeD, PRK10209
Members of DUF308 whose function may be known:
DUF4683 (PF15735.8): Domain of unknown function (DUF4683) (398 a.a.), 88 papers
IPR032757: DUF4683. This domain is found in eukaryotes, and is typically between 384 and 400 amino acids in length.
Overlapping families in CDD: PRK12323
Members of DUF4683 whose function may be known:
DUF202 (PF02656.18): Domain of unknown function (DUF202) (68 a.a.), 85 papers
IPR003807: DUF202. This entry describes a domain of unknown function found in bacterial inner membrane proteins and yeast vacuolar transporter chaperones.
Overlapping families in CDD: VTC1, YidH
Members of DUF202 whose function may be known:
DUF2470 (PF10615.12): Domain of unknown function (DUF2470) (77 a.a.), 85 papers
IPR019595: DUF2470. This entry represents an uncharacterised domain that can be found in a group of putative haem-iron utilisation proteins, such as HugZ. It can also be found in C-terminal of the glutamyl-tRNA reductase-binding (GluTRBP) protein from Arabidopsis. GluTRBP is involved in the regulation of glutamyl-tRNA reductase (GluTR) which is important for the synthesis and distribution of 5-aminolevulinate, a precursor in...
Members of DUF2470 whose function may be known:
DUF4097 (PF13349.9): Putative adhesin (249 a.a.), 84 papers
IPR025164: DUF4097. This has a putative all-beta structure with a twenty-residue repeat with a highly conserved repeating GD, gly-asp, motif. It may form part of a bacterial adhesin.
Overlapping families in CDD: YvlB
Members of DUF4097 whose function may be known:
DUF568 (PF04526.16): Protein of unknown function (DUF568) (101 a.a.), 83 papers
IPR045265: AIR12_DOMON. This entry represents the DOMON domain found in AIR12 and related proteins. Proteins containing this domain are plant proteins that may have a cytochrome b561 domain C-terminal to the DOMON domain. In Arabidopsis, AIR12 is a plasma membrane b-type cytochrome specific to flowering plants. AIR12 functions as either antioxidant in its oxidized state or a pro-oxidant in its reduced...
Overlapping families in CDD: B561, Cyt_b561_FRRS1_like, DOMON_CIL1_like, DoH
Members of DUF568 whose function may be known:
Cas_Cas4 (PF01930.20): Domain of unknown function DUF83 (162 a.a.), 82 papers
IPR022765: Dna2/Cas4_DUF83. This entry represents an uncharacterised domain found in several proteins, including DNA replication helicase Dna2, clustered regularly interspaced short palindromic repeats (CRISPR)-associated exonuclease Cas4 and putative RecB family exonuclease proteins. Dna2 is a DNA replication factor with single-stranded DNA-dependent ATPase, ATP-dependent nuclease, (5'-flap endonuclease) and helicase activities. Cas4 has been shown to be a 5' to 3' single stranded...
Overlapping families in CDD: Cas4, Cas4_I-A_I-B_I-C_I-D_II-B, cas4
Members of Cas_Cas4 whose function may be known:
DUF3223 (PF11523.11): Protein of unknown function (DUF3223) (75 a.a.), 82 papers
Members of DUF3223 whose function may be known:
DUF525 (PF04379.17): ApaG domain (87 a.a.), 81 papers
IPR007474: ApaG_domain. The apaG domain is a ~125 amino acids domain present in bacterial apaG proteins and in eukaryotic F-box proteins. The domain is named after the bacterial apaG protein, of which it forms the core. The domain also occurs in the C-terminal part of eukaryotic proteins with an N-terminal F-box domain. The Salmonella typhimurium apaG domain protein corD is involved...
Overlapping families in CDD: ApaG, apaG
Members of DUF525 whose function may be known:
UPF0029 (PF01205.22): Uncharacterized protein family UPF0029 (108 a.a.), 79 papers
IPR001498: Impact_N. The Impact protein is a translational regulator that ensures constant high levels of translation under amino acid starvation. It acts by interacting with Gcn1/Gcn1L1, thereby preventing activation of Gcn2 protein kinases (EIF2AK1 to 4) and subsequent down-regulation of protein synthesis. It is evolutionary conserved from eukaryotes to archaea. This entry represents the N-terminal domain of the Impact proteins.
Overlapping families in CDD: IMPACT_YIGZ, PRK11568, YIH1
Members of UPF0029 whose function may be known:
DUF1205 (PF06722.15): Protein of unknown function (DUF1205) (95 a.a.), 77 papers
IPR010610: DUF1205. This entry represents a conserved region of unknown function within bacterial glycosyl transferases. Many proteins containing this domain are members of the glycosyl transferase family 28 .
Overlapping families in CDD: GT1_Gtf-like, GT28_Beta-DGS-like, GT28_MurG, MGT, MurG, SpsG, YjiC, glycosyl_450act
Members of DUF1205 whose function may be known:
DUF262 (PF03235.17): Protein of unknown function DUF262 (221 a.a.), 76 papers
IPR004919: DUF262. This entry is found in prokaryotic proteins of unknown function.
Overlapping families in CDD: COG1479
Members of DUF262 whose function may be known:
DUF1356 (PF07092.15): Protein of unknown function (DUF1356) (232 a.a.), 75 papers
IPR009790: DUF1356_TMEM106. This family consists of several hypothetical mammalian proteins of around 250 residues in length. The function of this family is unknown.
Members of DUF1356 whose function may be known:
DUF839 (PF05787.16): Bacterial protein of unknown function (DUF839) (516 a.a.), 70 papers
IPR008557: DUF839. This family consists of bacterial proteins of unknown function.
Overlapping families in CDD: PhoX
Members of DUF839 whose function may be known:
DUF1524 (PF07510.14): Protein of unknown function (DUF1524) (139 a.a.), 70 papers
IPR011089: DUF1524. This domain contains a conserved HXXP motif. Proteins containing this domain belong to GmrSD restriction systems, which target and cleave DNA with glucosylated hydroxymethylcytosine (HMC).
Members of DUF1524 whose function may be known:
DUF3697 (PF12478.11): Ubiquitin-associated protein 2 (35 a.a.), 69 papers
IPR022166: UBAP2/Lig. This entry includes ubiquitin-associated protein 2 (UBAP2) from humans and protein lingerer (lig) from Drosophila melanogaster. Lig is a cytoplasmic protein involved in initiation and termination of copulation. Lig can act as a growth suppressor that associatess with the RNA-binding proteins Fragile X mental retardation protein 1 (FMR1) and Caprin (Capr) and directly interacts with and regulates the RNA-binding...
Overlapping families in CDD: PRK12678, UBA, UBA_UBAC2, UBA_UBP2_like, UBA_like_SF, ser_rich_anae_1
Members of DUF3697 whose function may be known:
DUF2428 (PF10350.12): THADA/TRM732, DUF2428 (276 a.a.), 68 papers
IPR019442: THADA/TRM732_DUF2428. This conserved domain is found in Thyroid adenoma-associated protein (THADA) from animals and in the yeast homologue tRNA (cytidine(32)-2'-O)-methyltransferase non-catalytic subunit TRM732. Trm732 forms a complex with the methyltransferase Trm7 to 2'- O- methylate tRNA residue 32 (Nm32), being required for Trm7 methylation activity. In humans, mutations of the Trm7 homologue FTSJ1, which interacts with THADA, impair Nm32 modifications,...
Overlapping families in CDD: COG5543
Members of DUF2428 whose function may be known:
DUF892 (PF05974.15): Domain of unknown function (DUF892) (159 a.a.), 66 papers
IPR010287: DUF892. This domain is found in several hypothetical bacterial proteins of unknown function.
Overlapping families in CDD: Ferritin_like, YciE, YciF
Members of DUF892 whose function may be known:
DUF4704 (PF15787.8): Neurobeachin/BDCP, DUF4704 alpha solenoid region (496 a.a.), 66 papers
IPR031570: NBEA/BDCP_DUF4704. This domain of unknown function is found in eukaryotes, on neurobeachin and BEACH domain-containing proteins (BDCPs). Mutations in this proteins are associated with Lipopolysaccharide-responsive and beige-like anchor (LRBA) deficiency.
Members of DUF4704 whose function may be known:
DUF520 (PF04461.16): Protein of unknown function (DUF520) (161 a.a.), 64 papers
IPR007551: DUF520. This entry represents the UPF0234 family of uncharacterised proteins, which includes YajQ. In Pseudomonas syringae, YajQ functions as a host protein involved in the temporal control of bacteriophage Phi6 gene transcription. It has been shown to bind to the phage's major structural core protein P1, most likely activating transcription by acting indirectly on the RNA polymerase. YajQ may remain...
Overlapping families in CDD: PRK05412, YajQ, YajQ_like
Members of DUF520 whose function may be known:
DUF953 (PF06110.14): Eukaryotic protein of unknown function (DUF953) (119 a.a.), 64 papers
IPR010357: TXNDC17_dom. This domain can be found in thioredoxin domain-containing protein 17 (also known as TRP14), which is a highly conserved and ubiquitously expressed oxidoreductase involved in controlling of cellular redox signalling pathways. TXNDC17 has been shown to efficiently reduce l-cystine and can directly reactivate oxidized protein-tyrosine phosphatase PTP1B .
Overlapping families in CDD: TRP14_like, TRX_family
Members of DUF953 whose function may be known:
DUF4378 (PF14309.9): Domain of unknown function (DUF4378) (164 a.a.), 64 papers
IPR025486: DUF4378. This domain is found in protein LONGIFOLIA 2. The function of this domain is not known.
Members of DUF4378 whose function may be known:
DUF386 (PF04074.15): YhcH/YjgK/YiaL (148 a.a.), 63 papers
IPR004375: NanQ/TabA/YiaL. This protein family consists of bacterial proteins. N-acetylneuraminate anomerase NanQ (NanQ, previously known as YhcH) plays a role sialic acid catabolism by opening both the alpha- and beta-forms of N-acetylneuraminate (sialic acid; Neu5Ac) to provide aceneuramate, the preferred substrate for the sialic acid aldolase (NanA). TabA (YjgK), also included in this entry, influences biofilm formation by toxin-antitoxin systems.
Overlapping families in CDD: EbgC, TIGR00022, ebgC
Members of DUF386 whose function may be known:
DUF481 (PF04338.15): Protein of unknown function, DUF481 (211 a.a.), 62 papers
IPR007433: DUF481. This family includes several proteins of uncharacterised function.
Overlapping families in CDD: YdiY
Members of DUF481 whose function may be known:
DUF1011 (PF06237.15): Protein of unknown function (DUF1011) (99 a.a.), 61 papers
IPR009357: Riboflavin_transptr. This entry includes a group of animal riboflavin transporters, including SLC52A1, SLC52A2 and SLC52A3 from humans. They are plasma membrane proteins that transport vitamin B2 (riboflavin, RF) into cells. In case of infection by retroviruses, they act as cell receptors to retroviral envelopes similar to the porcine endogenous retrovirus (PERV-A).
Members of DUF1011 whose function may be known:
DUF1127 (PF06568.14): Domain of unknown function (DUF1127) (37 a.a.), 61 papers
IPR009506: DUF1127. This family is found in several hypothetical bacterial proteins. In some cases it represents it represents the C-terminal region whereas in others it represents the whole sequence.
Overlapping families in CDD: YjiS
Members of DUF1127 whose function may be known:
DUF2154 (PF09922.12): Cell wall-active antibiotics response 4TMS YvqF (114 a.a.), 61 papers
IPR024425: DUF2154. This domain is found in various prokaryotic proteins, including cell wall-active antibiotic response proteins. This entry includes protein product of the yvqF gene, located immediately upstream of vraS. It is associated with glycopeptide resistance in Staphylococcus aureus.
Overlapping families in CDD: LiaF
Members of DUF2154 whose function may be known:
DUF295 (PF03478.21): Protein of unknown function (DUF295) (55 a.a.), 58 papers
IPR005174: DUF295. This domain is found in plant proteins, many of which also contain an F-box domain. This domain can be found in KIB3 from Arabidopsis. KIB3 is a F-box E3 ubiquitin ligase that promotes the degradation of GSK3-like kinase BIN2 while blocking its substrate access.
Overlapping families in CDD: PLN03215
Members of DUF295 whose function may be known:
DUF805 (PF05656.17): Protein of unknown function (DUF805) (105 a.a.), 55 papers
IPR008523: DUF805. This family consists of several bacterial proteins of unknown function.
Overlapping families in CDD: yhaH
Members of DUF805 whose function may be known:
DUF4111 (PF13427.9): Domain of unknown function (DUF4111) (103 a.a.), 55 papers
IPR025184: DUF4111. The function of this domain is not known, though it frequently occurs C-terminal to a nucleotidyltransferase domain.
Overlapping families in CDD: ANT_3pp_9_crypt, PRK13746
Members of DUF4111 whose function may be known:
DUF2370 (PF10176.12): Protein of unknown function (DUF2370) (226 a.a.), 54 papers
IPR019325: NEDD4/Bsd2. Proteins in this entry include the human NEDD4 family-interacting protein 1/2 (Ndfip1 and Ndfip2) and the yeast Bsd2 metal homeostatis proteins. Ndfip1 and Ndfip2 are endosomal membrane proteins that bind to and activate members of the Nedd4 family of E3 ubiquitin ligases. Ndfip1 plays a role in regulating metal transport in human neurons. Bsd2 is required for the targeting...
Overlapping families in CDD: NDFIP-like, NDFIP1, NDFIP2
Members of DUF2370 whose function may be known:
DUF3421 (PF11901.11): Protein of unknown function (DUF3421) (115 a.a.), 54 papers
IPR024518: DUF3421. This domain of unknown function is found in the fish toxin Natterin and in uncharacterised proteins.
Overlapping families in CDD: DM9, PFM_Dln1-like, PFM_HFR-2-like, PFM_LIN24-like, PFM_LSL-like, PFM_aerolysin-like, PFM_aerolysin_family, PFM_agglutinin-like, PFM_fascin-like, PFM_jacalin-like, PFM_natterin-3-like
Members of DUF3421 whose function may be known:
DUF3533 (PF12051.11): Protein of unknown function (DUF3533) (376 a.a.), 54 papers
IPR022703: DUF3533. This transmembrane domain is functionally uncharacterised. It is found in bacterial and eukaryotic proteins.
Members of DUF3533 whose function may be known:
DUF3337 (PF11816.11): Domain of unknown function (DUF3337) (172 a.a.), 53 papers
IPR021772: WDR48/Bun107. This entry includes WDR48 from animals, Bun107 from fission yeasts and Duf1 from budding yeasts. WDR48 (also known as UAF1) is a regulator of deubiquitinating complexes. Bun107 is required for the Ubp9 recruitment to septa and cell tips but also for its enzymatic activity at these specific locations.
Overlapping families in CDD: 7WD40, RAWUL_PCGF_like, Ubl_WDR48, WD40
Members of DUF3337 whose function may be known:
DUF3522 (PF12036.11): Protein of unknown function (DUF3522) (186 a.a.), 53 papers
IPR021910: NGX6/PGAP6/MYMK. Proteins in this family include PGAP6 (also known as TMEM8A), NGX6 (also known as TMEM8B) and myomaker (also known as TMEM8C). TMEM8C is embedded in the plasma membrane with seven membrane-spanning regions and a required intracellular C-terminal tail. It is essential for myoblast fusion and sufficient to promote fusion of fibroblasts with muscle cells. TMEM8A and TMEM8B has no...
Members of DUF3522 whose function may be known:
DUF155 (PF02582.17): RMND1/Sif2-Sif3/Mrx10, DUF155 (174 a.a.), 52 papers
IPR003734: DUF155. This entry represents a domain found in RMND1 from mammals, Sif2/Sif3 from fission yeasts and Rmd1/Rmd8/YDR282C (Mrx10) from budding yeasts. RMND1 and its yeast homologue, Mrx10, are mitochondrial proteins required for mitochondrial translation. Rmd1 and Rmd8 are cytoplasmic proteins required for sporulation.
Overlapping families in CDD: Rmd1
Members of DUF155 whose function may be known:
UPF0014 (PF03649.16): Uncharacterised protein family (UPF0014) (242 a.a.), 52 papers
IPR005226: UPF0014_fam. Characterised proteins in this family include probable iron export permease protein FetB, which is part of the ABC transporter complex FetAB, probably involved in iron export, and aluminum sensitive 3 protein, also part of an ABC transporter required for aluminum (Al) resistance. This family also includes integral membrane proteins currently uncharacterised.
Overlapping families in CDD: FetB, TIGR00245
Members of UPF0014 whose function may be known:
DUF903 (PF06004.15): Bacterial protein of unknown function (DUF903) (49 a.a.), 52 papers
IPR010305: DUF903. This family consists of several small bacterial proteins several of which are classified as putative lipoproteins. The function of this family is unknown.
Overlapping families in CDD: lipo_YgdI_YgdR, prsA
Members of DUF903 whose function may be known:
DUF485 (PF04341.15): Protein of unknown function, DUF485 (89 a.a.), 51 papers
IPR007436: DUF485. This family includes several putative integral membrane proteins.
Overlapping families in CDD: YjcH
Members of DUF485 whose function may be known:
UPF0227 (PF05728.15): Uncharacterised protein family (UPF0227) (187 a.a.), 50 papers
IPR008886: UPF0227/Esterase_YqiA. Despite being classed as uncharacterised proteins, the members of this family are almost certainly enzymes in that they contain a domain distantly related to . One of the members of this family YqiA has been shown to be a esterase. Other members, which include the Escherichia coli (strain K12) YcfP protein are uncharacterised.
Overlapping families in CDD: MhpC, PRK04940, PRK11071, YvaK, ycfP
Members of UPF0227 whose function may be known:
UPF0160 (PF03690.16): Uncharacterised protein family (UPF0160) (319 a.a.), 47 papers
IPR003226: Met-dep_prot_hydro. The function of this domain is not known, but it is found in several uncharacterised proteins and a probable metal dependent protein hydrolase.
Overlapping families in CDD: COG4286
Members of UPF0160 whose function may be known:
DUF535 (PF04393.16): Protein of unknown function (DUF535) (281 a.a.), 47 papers
IPR007488: DUF535. Family member Shigella flexneri VirK ( ) is a virulence protein required for the expression, or correct membrane localisation of IcsA (VirG) on the bacterial cell surface. This family also includes Pasteurella haemolytica lapB ( ), which is thought to be membrane-associated.
Overlapping families in CDD: VirK
Members of DUF535 whose function may be known:
DUF573 (PF04504.17): Protein of unknown function, DUF573 (95 a.a.), 46 papers
IPR007592: GEBP. This family of plant transcription factors includes GLABROUS1 enhancer-binding protein (GeBP) and GeBP-like proteins, and storekeeper and storekeeper-like (STKL) transcription factors. GeBP and GeBP-like proteins play a redundant role in cytokinin hormone pathway regulation. Storekeeper was identified as a B-box motif binding factor that regulates expression of patatin, a storage protein in potato. Storekeeper-like transcription factors STKL1 and STKL2...
Overlapping families in CDD: MDN1
Members of DUF573 whose function may be known:
UPF0556 (PF10572.12): UPF0556 domain (132 a.a.), 46 papers
IPR018887: MYDGF. The function of myeloid-derived growth factor is to protect and repair the heart after myocardial infarction.
Members of UPF0556 whose function may be known:
DUF4962 (PF16332.8): Domain of unknown function (DUF4962) (476 a.a.), 46 papers
IPR032518: HepII_N. This domain can be found in the N terminus of dermatan-sulfate epimerase from mammals, and heparinase II from bacteria.
Members of DUF4962 whose function may be known:
DUF1302 (PF06980.14): Protein of unknown function (DUF1302) (540 a.a.), 44 papers
IPR010727: DUF1302. This family contains a number of hypothetical bacterial proteins of unknown function that are approximately 600 residues long. Most family members seem to be from Pseudomonas.
Members of DUF1302 whose function may be known:
DUF543 (PF04418.15): Domain of unknown function (DUF543) (75 a.a.), 43 papers
IPR007512: Mic10. Mic10 (also known as MINOS1) is a component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.
Members of DUF543 whose function may be known:
DUF1325 (PF07039.14): SGF29 tudor-like domain (132 a.a.), 43 papers
IPR010750: SGF29_tudor-like_dom. SAGA-associated factor 29 is involved in transcriptional regulation, probably through association with histone acetyltransferase (HAT) complexes like the TFTC-HAT or STAGA complexes. It also may be involved in MYC-mediated oncogenic transformation. It is a component of the ATAC complex, which is a complex with histone acetyltransferase activity on histones H3 and H4. This entry represents a domain found in...
Overlapping families in CDD: Tudor_53BP1, Tudor_SF, Tudor_SGF29_rpt1, Tudor_SGF29_rpt2
Members of DUF1325 whose function may be known:
DUF1328 (PF07043.16): Protein of unknown function (DUF1328) (39 a.a.), 43 papers
IPR009760: DUF1328. This entry represents several hypothetical bacterial proteins of around 50 residues in length. The function of this family is unknown but is thought to be a membrane protein.
Overlapping families in CDD: YtjA
Members of DUF1328 whose function may be known:
DUF4149 (PF13664.9): Domain of unknown function (DUF4149) (102 a.a.), 43 papers
IPR025423: DUF4149. This presumed domain is functionally uncharacterised.
Members of DUF4149 whose function may be known:
DUF702 (PF05142.15): Domain of unknown function (DUF702) (147 a.a.), 42 papers
Overlapping families in CDD: LRP1_Cterm, put_zinc_LRP1
Members of DUF702 whose function may be known:
DUF3504 (PF12012.11): Domain of unknown function (DUF3504) (162 a.a.), 42 papers
IPR021893: DUF3504. This presumed domain is functionally uncharacterised. This domain is found in eukaryotes. This domain is typically between 156 to 173 amino acids in length.
Members of DUF3504 whose function may be known:
DUF179 (PF02622.18): Uncharacterized ACR, COG1678 (160 a.a.), 41 papers
IPR003774: UPF0301. This entry describes proteins of unknown function. Proteins in this family include AlgH from Pseudomonas aeruginosa. AlgH is involved in the transcriptional regulation of alginate biosynthesis. However, there is no evidence for such function in proteins belonging to this family.
Overlapping families in CDD: AlgH, PRK00228
Members of DUF179 whose function may be known:
DUF1338 (PF07063.16): Domain of unknown function (DUF1338) (325 a.a.), 41 papers
IPR009770: DUF1338. This domain is found in a variety of bacterial and fungal hypothetical proteins of unknown function. The structure of this domain has been solved by structural genomics. The structure implies a zinc-binding function, so it is a putative metal hydrolase (information derived from TOPSAN for PDB:3iuz).
Overlapping families in CDD: VOC_YdcJ_like, VOC_like, YdcJ
Members of DUF1338 whose function may be known:
DUF1771 (PF08590.13): Domain of unknown function (DUF1771) (64 a.a.), 41 papers
IPR013899: DUF1771. This domain is highly charged and may represent a small helical extension of the Smr domain , known as N-ext, whose function is not yet clear.
Overlapping families in CDD: CUE_N4BP2, SMR
Members of DUF1771 whose function may be known:
DUF3573 (PF12097.11): Protein of unknown function (DUF3573) (383 a.a.), 41 papers
IPR021956: DUF3573. This family of proteins is functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 372 to 530 amino acids in length.
Overlapping families in CDD: LbtU_sider_porin
Members of DUF3573 whose function may be known:
DUF4123 (PF13503.9): Domain of unknown function (DUF4123) (127 a.a.), 41 papers
IPR025391: DUF4123. This presumed domain is functionally uncharacterised.
Members of DUF4123 whose function may be known:
DUF692 (PF05114.16): Protein of unknown function (DUF692) (263 a.a.), 40 papers
IPR007801: UPF0276. The proteins in this entry are functionally uncharacterised.
Overlapping families in CDD: COG3220, PRK05409
Members of DUF692 whose function may be known:
DUF1971 (PF09313.14): Domain of unknown function (DUF1971) (80 a.a.), 40 papers
IPR015392: DUF1971. This uncharacterised domain is predominantly found in bacterial Tellurite resistance proteins.
Overlapping families in CDD: PRK12335, TehB
Members of DUF1971 whose function may be known:
DUF493 (PF04359.17): Protein of unknown function (DUF493) (84 a.a.), 39 papers
IPR007454: UPF0250. This family includes several proteins of uncharacterised function.
Overlapping families in CDD: PRK00341, PRK02047, PRK04998, YbeD
Members of DUF493 whose function may be known:
DUF2219 (PF09982.12): Uncharacterized protein conserved in bacteria (DUF2219) (290 a.a.), 39 papers
IPR018707: DUF2219. This entry contains proteins that have no known function.
Overlapping families in CDD: COG3528
Members of DUF2219 whose function may be known:
DUF444 (PF04285.15): Protein of unknown function (DUF444) (421 a.a.), 38 papers
IPR006698: UPF0229. This family consists of bacterial proteins of unknown function.
Overlapping families in CDD: PRK05325, YeaH, spore_yhbH
Members of DUF444 whose function may be known:
UPF0203 (PF05254.15): Uncharacterised protein family (UPF0203) (69 a.a.), 38 papers
IPR007918: MDM35_apoptosis. This is a family of small highly conserved proteins. In Saccharomyces cerevisiae (Baker's yeast) the gene YKL053C-A (MDM35) is one of the genes essential for maintenance of normal mitochondrial distribution and morphology (MDM); wherease in Homo sapiens (Human), p53CSV, is a direct transcriptional target for p53 and appears to be a cell-survival mediator in response to genotoxic stress including...
Overlapping families in CDD: PLN03079
Members of UPF0203 whose function may be known:
DUF761 (PF05553.14): Cotton fibre expressed protein (36 a.a.), 38 papers
IPR008480: DUF761_pln. This family consists of several plant proteins of unknown function, including pathogen-associated molecular patterns-induced protein A70 from Arabidopsis thaliana, which is induced during Pseudomonas syringae infection by jasmonic acid and wounding.
Members of DUF761 whose function may be known:
DUF1547 (PF07577.14): Domain of Unknown Function (DUF1547) (60 a.a.), 38 papers
IPR011443: DUF1547. This domain appears to be found only in a small family of Chlamydia species. It is usually found repeated. This domain can be found in translocated actin-recruiting phosphoprotein (Tarp) from Chlamydia trachomatis serovar L2. Tarp appears to initiate or participate in signalling events that regulate the actin recruitment, which ultimately leads to internalization.
Overlapping families in CDD: act_recrut_TARP
Members of DUF1547 whose function may be known:
DUF445 (PF04286.15): Protein of unknown function (DUF445) (367 a.a.), 37 papers
IPR007383: DUF445. This entry represents a large family of proteins with unknown function. They are predicted to be transmembrane (TM) proteins with 2 or 3 TM domains.
Overlapping families in CDD: YheB, YjiN
Members of DUF445 whose function may be known:
DUF533 (PF04391.15): Protein of unknown function (DUF533) (178 a.a.), 37 papers
IPR007486: YebE. Some family members may be secreted or integral membrane proteins. This entry includes the inner membrane protein YebE from Escherichia coli.
Overlapping families in CDD: YebE, terB_like, terB_like_YebE
Members of DUF533 whose function may be known:
DUF1751 (PF08551.13): Eukaryotic integral membrane protein (DUF1751) (99 a.a.), 37 papers
IPR013861: TMEM115/Pdh1/Rbl19. This entry represents a group of eukaryotic transmembrane proteins, including TMEM115 from animals, Pdh1 from fission yeasts and Rbl19 from Arabisopsis. Human TMEM115 is an integral membrane protein of the Golgi complex involved in retrograde transport. Budding yeast TMEM115 homologue, YOL107W, has been shown to localise COP II vesicles.
Members of DUF1751 whose function may be known:
DUF498 (PF04430.17): Protein of unknown function (DUF498/DUF598) (110 a.a.), 36 papers
IPR007523: NDUFAF3/AAMDC. This entry includes NDUFAF3, an essential factor for the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I), and the Mth938 domain-containing protein. The crystal structure of NDUFAF3 revealed a 3-layer beta+alpha/beta/alpha topology. NADH:ubiquinone oxidoreductase (complex I) ( ) is a respiratory-chain enzyme that catalyses the transfer of two electrons from NADH to ubiquinone in a reaction that is associated...
Overlapping families in CDD: COG1504, COG3737, Mth938, Mth938-like, Mth938_2P1-like, Xcc1710_like
Members of DUF498 whose function may be known:
DUF4185 (PF13810.9): Domain of unknown function (DUF4185) (316 a.a.), 36 papers
IPR025442: DUF4185. This presumed domain is functionally uncharacterised.
Members of DUF4185 whose function may be known:
DUF6595 (PF20238.1): Family of unknown function (DUF6595) (144 a.a.), 36 papers
Overlapping families in CDD: LPMO_auxiliary-like
Members of DUF6595 whose function may be known:
DUF559 (PF04480.15): Protein of unknown function (DUF559) (109 a.a.), 35 papers
IPR007569: DUF559. This entry represents a domain of unknown function found in C terminus of VSR (very short patch repair) endonucleases. VSR recognises a TG mismatched base pair, generated after spontaneous deamination of methylated cytosines, and cleaves the phosphate backbone on the 5' side of the thymine. GT mismatches can lead to C-to-T transition mutations if not repaired. VSR repairs the...
Overlapping families in CDD: Endonuclease_DUF559, Hef-like, Vsr
Members of DUF559 whose function may be known:
DUF934 (PF06073.15): Bacterial protein of unknown function (DUF934) (107 a.a.), 35 papers
IPR008318: UCP030820. There are currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function.
Overlapping families in CDD: COG3749
Members of DUF934 whose function may be known:
DUF1264 (PF06884.14): Protein of unknown function (DUF1264) (171 a.a.), 35 papers
IPR010686: OBAP-like. This entry includes a group of oil body associated proteins (OBAPs) from plants and some uncharacterised proteins from fungi and bacteria. The plant obap proteins are predominantly expressed during embryo development and may be involved in the stability of oil bodies.
Members of DUF1264 whose function may be known:
DUF1722 (PF08349.14): Protein of unknown function (DUF1722) (117 a.a.), 35 papers
IPR013560: DUF1722. This domain of unknown function is found in bacteria and archaea and is homologous to the hypothetical protein ybgA from Escherichia coli.
Overlapping families in CDD: PRK10167, YbgA
Members of DUF1722 whose function may be known:
DUF1907 (PF08925.14): Domain of Unknown Function (DUF1907) (282 a.a.), 35 papers
IPR015021: DUF1907. The structure of this domain displays an alpha-beta-beta-alpha four layer topology, with an HxHxxxxxxxxxH motif that coordinates a zinc ion, and an acetate anion at a site that likely supports the enzymatic activity of an ester hydrolase.
Overlapping families in CDD: AldB-like, DUF1907
Members of DUF1907 whose function may be known:
DUF402 (PF04167.16): Protein of unknown function (DUF402) (68 a.a.), 34 papers
IPR007295: DUF402. This beta barrel domain is found in FomD, which is a predicted protein from a fosfomycin biosynthesis gene cluster in Streptomyces wedmorensis. Its function is unknown.
Members of DUF402 whose function may be known:
DUF1329 (PF07044.14): Protein of unknown function (DUF1329) (365 a.a.), 34 papers
IPR010752: DUF1329. This family consists of several hypothetical bacterial proteins of around 475 residues in length. The majority of family members are from Pseudomonas species but the family also contains sequences from Shewanella oneidensis and Thauera aromatica.
Overlapping families in CDD: LolA_like
Members of DUF1329 whose function may be known:
DUF1440 (PF07274.15): Protein of unknown function (DUF1440) (135 a.a.), 34 papers
IPR009898: DUF1440. This family contains a number of bacterial proteins of unknown function approximately 180 residues long. These are possibly integral membrane proteins.
Overlapping families in CDD: YagU
Members of DUF1440 whose function may be known:
Cg6151-P (PF10233.12): Uncharacterized conserved protein CG6151-P (113 a.a.), 33 papers
IPR019365: TVP18/Ca-channel_flower. This is a family of small (less than 200 residue long) proteins that are conserved from fungi to humans. Family members include the TVP18 Golgi membrane proteins that are involved in vesicular trafficking and the calcium channel flower proteins, which form calcium channels that regulate synaptic endocytosis.
Overlapping families in CDD: Cg6151-P
Members of Cg6151-P whose function may be known:
DUF697 (PF05128.15): Domain of unknown function (DUF697) (162 a.a.), 32 papers
IPR021147: DUF697. Proteins in this entry have no known function.
Overlapping families in CDD: COG3597, PRK05415, YcjF, hyp_HI0043
Members of DUF697 whose function may be known:
DUF1681 (PF07933.17): Protein of unknown function (DUF1681) (156 a.a.), 32 papers
IPR012466: NECAP_PHear. This PH-like domain can be found in the N-terminal region of NECAPs (also known as adaptin ear-binding coat-associated proteins). NECAPs are alpha-ear-binding proteins that enrich on clathrin-coated vesicles (CCVs). NECAP-1 is expressed in brain and non-neuronal tissues and cells while NECAP-2 is ubiquitously expressed. The PH-like domain of NECAPs is a protein-binding interface that mimics the FxDxF motif binding...
Overlapping families in CDD: PH-like, PHear_NECAP, PRK14959
Members of DUF1681 whose function may be known:
DUF4154 (PF13689.9): YfiR/HmsC-like (143 a.a.), 32 papers
IPR025293: YfiR/HmsC-like. YfiR has been shown to regulate YfiN, a diguanylate cyclase and a bifunctional protein that produces c-di-GMP in response to reductive stress and then dynamically relocates to the division site to arrest cell division in response to envelope stress in Escherichia coli. YfiR may serve as a periplasmic redox sensor that regulates YfiN activity in response to reducing conditions....
Members of DUF4154 whose function may be known:
UPF0047 (PF01894.20): Uncharacterised protein family UPF0047 (115 a.a.), 31 papers
IPR001602: UPF0047. This family contains small uncharacterised proteins of 14 to 16kDa mainly from bacteria although the signatures also occur in a hypothetical protein from archaea and from yeast.
Overlapping families in CDD: TIGR00149_YjbQ, YjbQ
Members of UPF0047 whose function may be known:
DUF454 (PF04304.16): Protein of unknown function (DUF454) (115 a.a.), 31 papers
IPR007401: DUF454. This entry includes YbaN from Escherichia coli. It is an inner membrane protein.
Overlapping families in CDD: PRK10527, YbaN
Members of DUF454 whose function may be known:
DUF488 (PF04343.16): Protein of unknown function, DUF488 (122 a.a.), 31 papers
IPR007438: DUF488. This family includes several proteins of uncharacterised function.
Overlapping families in CDD: YeaO
Members of DUF488 whose function may be known:
DUF747 (PF05346.14): Eukaryotic membrane protein family (319 a.a.), 31 papers
IPR008010: Tatp1. This family of membrane proteins is conserved in eukaryotes. It includes Tapt1 (transmembrane anterior posterior transformation 1) and homologues. Analysis of mouse Tapt1 has shown it to be involved in patterning of the vertebrate axial skeleton. Its cellular function is not known, but defective Tapt1 disrupts Golgi morphology and trafficking, and normal primary cilium formation. The homologues in yeast,...
Members of DUF747 whose function may be known:
DUF1077 (PF06417.15): Protein of unknown function (DUF1077) (118 a.a.), 31 papers
IPR009445: TMEM85/Emc4. This entry includes TMEM85 from mammals and Emc4 from budding yeasts. They inhibit hydrogen peroxide mediated cell death in yeast. Emc4 is part of the ER membrane complex (EMC) that may play a role in protein folding.
Members of DUF1077 whose function may be known:
DUF1430 (PF07242.14): Protein of unknown function (DUF1430) (100 a.a.), 31 papers
IPR006541: Bacteriocin_ass. These sequences represent a family of integral membrane proteins, most of which are about 650 residues in size and predicted to span the membrane seven times. Nearly half of the members of this family are found in association with a member of the lactococcin 972 family of bacteriocins ( ). Others may be associated with uncharacterised proteins that may...
Overlapping families in CDD: COG4652, bact_immun_7tm
Members of DUF1430 whose function may be known:
DUF1906 (PF08924.14): Domain of unknown function (DUF1906) (198 a.a.), 31 papers
IPR015020: DUF1906. This entry represents a family of uncharacterised hypothetical bacterial proteins, including the putative peptidoglycan hydrolase Rv2525c from Mycobacterium tuberculosis.
Overlapping families in CDD: GH25_BacA-like
Members of DUF1906 whose function may be known:
DUF1972 (PF09314.14): Domain of unknown function (DUF1972) (186 a.a.), 31 papers
IPR015393: DUF1972. This domain is functionally uncharacterised and found in bacterial glycosyltransferases and rhamnosyltransferases.
Overlapping families in CDD: GT4-like, Glycosyltransferase_GTB-type, RfaB
Members of DUF1972 whose function may be known:
Rv2175c_C (PF18367.4): Rv2175c C-terminal domain of unknown function (56 a.a.), 31 papers
IPR041098: Rv2175c_C. This is the C-terminal domain of unknown function found in actinomycetes such as M. tuberculosis Rv2175c. Rv2175c has a DNA binding activity and possesses a winged helix-turn-helix fold, furthermore it is identified as a substrate of the PknL kinase.
Members of Rv2175c_C whose function may be known:
DUF775 (PF05603.15): Protein of unknown function (DUF775) (199 a.a.), 30 papers
IPR008493: DUF775. The function of the DUF775 domain is not clear.
Members of DUF775 whose function may be known:
DUF2046 (PF09755.12): Uncharacterized conserved protein H4 (DUF2046) (304 a.a.), 30 papers
IPR019152: DUF2046. This is the conserved N-terminal 350 residues of a family of proteins of unknown function possibly containing a coiled-coil domain.
Overlapping families in CDD: COG4913, PRK00409, PRK03918, PRK12704, SMC_prok_A, SMC_prok_B, SbcC, Smc, pneumo_PspA
Members of DUF2046 whose function may be known:
DUF2406 (PF10295.12): Uncharacterised protein (DUF2406) (63 a.a.), 30 papers
IPR018809: DUF2406. This entry represents a family of small proteins conserved in fungi. The function is not known.
Members of DUF2406 whose function may be known:
NTPase_I-T (PF01931.21): Protein of unknown function DUF84 (163 a.a.), 29 papers
IPR026533: NTPase/PRRC1. This entry represents a domain found in non-canonical purine NTP phosphatases and in PRRC1 (proline-rich and coiled-coil-containing protein 1). These phosphatases hydrolyse non-canonical purine nucleotides such as XTP and ITP to their respective diphosphates derivatives. PRRC1 is a Golgi-associated protein of unknown function.
Overlapping families in CDD: PRK01170, PRK03114, PRK03941, PRK05074, TIGR00258, YjjX
Members of NTPase_I-T whose function may be known:
DUF333 (PF03891.18): Domain of unknown function (DUF333) (48 a.a.), 29 papers
IPR005590: DUF333. This family consists of functionally uncharacterised bacterial proteins.
Overlapping families in CDD: Hlx, flgH
Members of DUF333 whose function may be known:
DUF1398 (PF07166.14): Protein of unknown function (DUF1398) (119 a.a.), 29 papers
IPR009833: DUF1398. This family consists of several hypothetical bacterial proteins of around 130 residues in length. The function of this family is unknown.
Overlapping families in CDD: YbcV
Members of DUF1398 whose function may be known:
DUF1656 (PF07869.15): Protein of unknown function (DUF1656) (56 a.a.), 29 papers
IPR012451: DUF1656. The proteins in this entry have no known function and belong to the AaeX family.
Overlapping families in CDD: PRK11594
Members of DUF1656 whose function may be known:
DUF2465 (PF10239.12): Protein of unknown function (DUF2465) (302 a.a.), 29 papers
IPR018797: FAM98. FAM98A, B and C are glycine-rich proteins found from worms to humans. FAM98A contains a tubulin-binding calponin homology domain. It interacts with PLEKHM1 and functions in lysosome positioning in osteoclasts. FAM98A and FAM98B are included in a novel complex with DDX1 and C14orf166 and are involved in colorectal cancer progression.
Members of DUF2465 whose function may be known:
Ytp1 (PF10355.12): Protein of unknown function (Ytp1) (277 a.a.), 29 papers
IPR018827: Uncharacterised_YCR061W_C. This entry represents a conserved sequence region found a family of fungal proteins. It appears to contain regions similar to mitochondrial electron transport proteins. The C-terminal domain is hydrophobic and negatively charged. There are consensus sites for both N-linked glycosylation and cAMP-dependent protein kinase phosphorylation.
Overlapping families in CDD: Cyt_b561_FRRS1_like
Members of Ytp1 whose function may be known:
DUF4352 (PF11611.11): Domain of unknown function (DUF4352) (125 a.a.), 29 papers
IPR029051: DUF4352. This immunoglobulin-like domain can be found in a group of proteins that fall into the antigen MPT63/MPB63 (immunoprotective extracellular protein) superfamily, such as uncharacterised lipoprotein YjhA ( ).
Members of DUF4352 whose function may be known:
UPF0220 (PF05255.14): Uncharacterised protein family (UPF0220) (166 a.a.), 28 papers
IPR007919: UPF0220. This family of proteins is functionally uncharacterised.
Members of UPF0220 whose function may be known:
DUF1107 (PF06526.15): Protein of unknown function (DUF1107) (63 a.a.), 28 papers
IPR009491: DUF1107. This family consists of several short, hypothetical bacterial proteins of unknown function.
Members of DUF1107 whose function may be known:
DUF1120 (PF06551.15): Protein of unknown function (DUF1120) (116 a.a.), 28 papers
IPR010546: DUF1120. This family consists of several bacterial proteins, at least one of which is involved in enzyme induction following nitrogen deprivation. The exact function of this family is unknown
Overlapping families in CDD: PRK15302, PRK15303
Members of DUF1120 whose function may be known:
DUF1151 (PF06625.14): Protein of unknown function (DUF1151) (111 a.a.), 28 papers
IPR009533: FAM107. This entry includes FAM107A/B. FAM107A (also known as DRR1) is an actin-associated protein that plays important roles in tumor cell growth, neuron survival and spine formation. The function of FAM107B is not clear.
Members of DUF1151 whose function may be known:
DUF1307 (PF06998.14): Protein of unknown function (DUF1307) (123 a.a.), 28 papers
IPR009736: DUF1307. This family consists of several hypothetical bacterial proteins of around 150 residues in length. Some family members are described as putative lipoproteins but the function of the family is unknown.
Overlapping families in CDD: YehR
Members of DUF1307 whose function may be known:
DUF1949 (PF09186.14): Domain of unknown function (DUF1949) (56 a.a.), 28 papers
IPR015269: UPF0029_Impact_C. Members of this entry are a set of functionally uncharacterised hypothetical bacterial proteins. They adopt a ferredoxin-like fold, with a beta-alpha-beta-beta-alpha-beta arrangement. This entry contains the protein Impact, which is a translational regulator that ensures constant high levels of translation under amino acid starvation. It acts by interacting with Gcn1/Gcn1L1, thereby preventing activation of Gcn2 protein kinases (EIF2AK1 to...
Overlapping families in CDD: IMPACT_YIGZ, PRK11568, YIH1
Members of DUF1949 whose function may be known:
ABC_transp_aux (PF09822.12): ABC-type uncharacterized transport system (265 a.a.), 28 papers
IPR019196: ABC_transp_unknown. This domain is found in various eukaryotic and prokaryotic intra-flagellar transport proteins involved in gliding motility, as well as in several hypothetical proteins.
Overlapping families in CDD: GldG
Members of ABC_transp_aux whose function may be known:
DUF2063 (PF09836.12): Putative DNA-binding domain (83 a.a.), 28 papers
IPR018640: DUF2063. This entry represents the N-terminal part of a Neisseria protein ( ), . It runs from residues 31-117 as a helical bundle with 4 main helices. From genomic context and the fold of the C-terminal part, it is suggested that this protein is involved in transcriptional regulation.
Overlapping families in CDD: COG3219
Members of DUF2063 whose function may be known:
DUF2427 (PF10348.12): Domain of unknown function (DUF2427) (105 a.a.), 28 papers
IPR018825: DUF2427. This entry represents the N-terminal region of a family of proteins conserved in fungi. Several of these proteins are annotated as being Ftp1 but this could not be confirmed. Their function is not known.
Overlapping families in CDD: Cyt_b561_FRRS1_like
Members of DUF2427 whose function may be known:
VraX (PF17412.5): Family of unknown function (55 a.a.), 28 papers
IPR035374: VraX. This entry represents the VraX proteins from Staphylococcus aureus. The vraX gene belongs to the vra operon together with the vraA gene encoding for a long chain fatty acid-CoA ligase, which is up-regulated in the VISA (vancomycin-intermediate S. aureus). The gene product, a 55-amino acids protein,is upregulated in the stress response to cell wall-active antibiotics and other surface-interactive molecules....
Members of VraX whose function may be known:
UPF0093 (PF03653.16): Uncharacterised protein family (UPF0093) (146 a.a.), 27 papers
IPR005265: HemJ-like. This entry includes HemJ ( ) from Synechocystis sp. (strain PCC 6803 / Kazusa). It is essential for protoporphyrinogen IX oxidase activity and is functionally coupled with coproporphyrinogen III oxidase.
Overlapping families in CDD: COG1981, TIGR00701
Members of UPF0093 whose function may be known:
DUF1043 (PF06295.15): Protein of unknown function (DUF1043) (124 a.a.), 27 papers
IPR009386: DUF1043. This entry consists of several hypothetical bacterial proteins of unknown function.
Overlapping families in CDD: PRK11677, YhcB
Members of DUF1043 whose function may be known:
DUF1218 (PF06749.15): Protein of unknown function (DUF1218) (96 a.a.), 27 papers
IPR009606: Modifying_wall_lignin1/2. This family contains plant proteins modifying wall lignin-1 (MWL1), modifying wall lignin-2 (MWL2) and homologues. MWL1 and 2 are involved in secondary cell wall biology, specifically lignin biosynthesis. Proteins included in this family contain a number of conserved cysteine residues.
Members of DUF1218 whose function may be known:
DUF1648 (PF07853.14): Domain of unknown function (DUF1648) (49 a.a.), 27 papers
IPR012867: DUF1648. This domain is found in proteins expressed by bacterial and archaeal species. One such protein is immunity protein SdpI ( ) from Bacillus subtilis, which provides protection for the cell against the toxic effects of its own SdpC killing factor, and also functions as a receptor/signal transduction protein.
Overlapping families in CDD: COG5658
Members of DUF1648 whose function may be known:
DUF2228 (PF10228.12): Uncharacterised conserved protein (DUF2228) (251 a.a.), 27 papers
IPR019361: HPF1. Histone PARylation factor 1 (HPF1, previously known as C4orf27) is a key regulator of ADP-ribosylation signaling in response to DNA damage. It has been demonstrated that HPF1 forms a complex with PARP-1 (poly(ADP-ribose) polymerase 1) and is recruited to DNA lesions in a PARP-1-dependent manner, but independently of PARP-1 catalytic ADP-ribosylation activity. HPF1 has also been shown limit DNA...
Members of DUF2228 whose function may be known:
DUF3502 (PF12010.11): Domain of unknown function (DUF3502) (130 a.a.), 27 papers
IPR022627: DUF3502. This domain is about 140 amino acids in length and is functionally uncharacterised. It can be found at the C terminus of the SP_0092 protein from Streptococcus pneumoniae serotype 4. SP_0092 is a carbohydrate ABC transporter substrate-binding protein.
Overlapping families in CDD: PBP2_AlgQ1_2, PBP2_AlgQ_like, PBP2_AlgQ_like_1, PBP2_AlgQ_like_2, PBP2_AlgQ_like_3, PBP2_AlgQ_like_4, PBP2_MalE, PBP2_TMBP, PBP2_TMBP_like, PBP2_UgpB, PBP2_XBP1_like, UgpB
Members of DUF3502 whose function may be known:
DUF600 (PF04634.15): Protein of unknown function, DUF600 (146 a.a.), 26 papers
IPR006728: EsaG-like. Proteins in this entry include the YezG protein from Bacillus subtilis and EsaG from Staphylococcus aureus. YezG is probably the antitoxin component of a toxin-antitoxin (TA) module. EsaG is part of toxin-antitoxin system that counteracts the toxic effect of EssD via direct interaction.
Overlapping families in CDD: staph_tand_hypo
Members of DUF600 whose function may be known:
DUF846 (PF05832.15): Eukaryotic protein of unknown function (DUF846) (139 a.a.), 26 papers
IPR008564: TVP23-like. Tvp23 is a Golgi membrane protein involved in vesicular trafficking.
Members of DUF846 whose function may be known:
DUF167 (PF02594.19): Uncharacterised ACR, YggU family COG1872 (75 a.a.), 25 papers
IPR003746: DUF167. This entry describes proteins of unknown function. Structures for two of these proteins, YggU from Escherichia coli and MTH637 from the archaea Methanobacterium thermoautotrophicum, have been determined; they have a core 2-layer alpha/beta structure consisting of beta(2)-loop-alpha-beta(2)-alpha.
Overlapping families in CDD: PRK00647, PRK01310, PRK01530, PRK04021, PRK05090, TIGR00251, YggU
Members of DUF167 whose function may be known:
DUF188 (PF02639.17): Uncharacterized BCR, YaiI/YqxD family COG1671 (130 a.a.), 25 papers
IPR003791: UPF0178. This entry describes proteins of unknown function.
Overlapping families in CDD: PIN_LabA-like, PIN_YqxD-like, PRK00124, YaiI
Members of DUF188 whose function may be known:
UPF0172 (PF03665.16): Uncharacterised protein family (UPF0172) (193 a.a.), 25 papers
IPR005366: EMC8/9. Saccharomyces cerevisiae ER membrane protein complex (EMC) comprises six subunits. Four and three additional subunits have been identified in mammals and Drosophila, respectively. EMC is required for protein folding in the endoplasmic reticulum (ER). It also facilitates lipid transfer from ER to mitochondria. This family includes mammalian subunits EMC8 and EMC9, and Drosophila EMC8/9 homologue. EMC8 is also known...
Overlapping families in CDD: MPN, MPN_UPF0172
Members of UPF0172 whose function may be known:
DUF615 (PF04751.17): Protein of unknown function (DUF615) (153 a.a.), 25 papers
IPR006839: Ribosome-assoc_YjgA. The entry contains the Escherichia coli (strain K12) protein YjgA ( ), which has been shown to comigrate with the mature 50S ribosome subunit. Therefore it either represents a novel ribosome-associated protein or it is associated with a different oligomeric complex that comigrates with ribosomal particles. The proteins in this entry are functionally uncharacterised.
Overlapping families in CDD: PRK05255, YjgA, YjgA-like
Members of DUF615 whose function may be known:
DUF725 (PF05267.15): Protein of unknown function (DUF725) (121 a.a.), 25 papers
IPR007931: TsetseEP. This domain can be found in tsetseEP, a gut protein from the tsetse Glossina morsitans. Towards the C terminus, the protein contains 59 (EP) repeats.
Members of DUF725 whose function may be known:
DUF808 (PF05661.15): Protein of unknown function (DUF808) (303 a.a.), 25 papers
IPR008526: YedI. This family of proteins includes inner membrane protein YedI.
Overlapping families in CDD: MutK, PRK10062
Members of DUF808 whose function may be known:
DUF1375 (PF07119.15): Protein of unknown function (DUF1375) (53 a.a.), 25 papers
IPR010780: DUF1375. This family consists of several hypothetical, putative lipoproteins of around 80 residues in length. Members of this family seem to be specific to the class Gammaproteobacteria. The function of this family is unknown.
Overlapping families in CDD: PRK10175, PRK11616, YceK
Members of DUF1375 whose function may be known:
DUF2057 (PF09829.12): Uncharacterized protein conserved in bacteria (DUF2057) (192 a.a.), 25 papers
IPR018635: UPF0319. The proteins in this entry are functionally uncharacterised.
Overlapping families in CDD: PRK01904, PRK03641, PRK04517, YccT
Members of DUF2057 whose function may be known:
DUF3592 (PF12158.11): Protein of unknown function (DUF3592) (148 a.a.), 25 papers
IPR021994: DUF3592. This family of proteins is functionally uncharacterised.This family of proteins is found in bacteria, archaea, eukaryotes and viruses. Proteins in this family are typically between 150 and 242 amino acids in length.
Members of DUF3592 whose function may be known:
DUF3699 (PF12480.11): Protein of unknown function (DUF3699) (71 a.a.), 25 papers
IPR022168: DUF3699. This domain family is found in eukaryotes, and is approximately 80 amino acids in length.
Overlapping families in CDD: PRK12323, PRK13875
Members of DUF3699 whose function may be known:
DUF3730 (PF12530.11): Focadhesin/RST1, DUF3730 (229 a.a.), 25 papers
IPR022542: FOCAD/RST1_DUF3730. This domain of unknown function is found in Focadhesin from animals and RST1 (RESURRECTION 1) from plants. Focadhesin (FOCAD) is a focal adhesion protein with potential tumour suppressor function in gliomas. RST1 was originally identified in a genetic screen for factors involved in the biosynthesis of epicuticular waxes. Later, RST1 and RST1 INTERACTING PROTEIN (RIPR) have been shown to...
Members of DUF3730 whose function may be known:
DUF4538 (PF15061.9): Domain of unknown function (DUF4538) (57 a.a.), 25 papers
IPR027917: SMIM20. SMIM20, also known as MITRAC7, acts as a COX1-specific chaperone and is required for cytochrome c oxidase biogenesis.
Members of DUF4538 whose function may be known:
DUF72 (PF01904.21): Protein of unknown function DUF72 (218 a.a.), 24 papers
IPR002763: DUF72. The function of this family is unknown. Aquifex aeolicus has two copies of this protein. A probable aspartyl-tRNA synthetase from Escherichia coli belongs to this group.
Overlapping families in CDD: PRK10302, YecE
Members of DUF72 whose function may be known:
DUF417 (PF04224.15): Protein of unknown function, DUF417 (175 a.a.), 24 papers
IPR007339: RclC-like. This family of uncharacterised proteins appears to be restricted to proteobacteria. It includes inner membrane protein RclC (YkgD) from Escherichia coli , which is a reactive chlorine-specific transcription factor.
Overlapping families in CDD: YkgB
Members of DUF417 whose function may be known:
DUF679 (PF05078.15): Protein of unknown function (DUF679) (163 a.a.), 24 papers
IPR007770: DMP. This entry includes plant protein DMP, including Arabidopsis AtDMP1-10. DMP1 is a membrane protein that may be involved in membrane fission during breakdown of the ER and the tonoplast during leaf senescence and in membrane fusion during vacuole biogenesis in roots. DMP8 and DMP9 have been shown to facilitate gamete fusion during double fertilization in flowering plants.
Members of DUF679 whose function may be known:
DUF760 (PF05542.14): Protein of unknown function (DUF760) (84 a.a.), 24 papers
IPR008479: DUF760. This entry represents a family of uncharacterised proteins, including chloroplastic UV-B-induced protein At3g17800 from Arabidopsis.
Members of DUF760 whose function may be known:
DUF778 (PF05608.15): Protein of unknown function (DUF778) (189 a.a.), 24 papers
IPR008496: TMEM222/RTE1. This entry includes TMEM222 from animals and RTE1 (REVERSION-TO-ETHYLENE SENSITIVITY1) from Arabidopsis. RTE1 is positive regulator of the ETR1 ethylene receptor. This entry also includes Arabidopsis RTE1 homologue, RTH, which acts via RTE1 in regulating ethylene responses and signaling.
Members of DUF778 whose function may be known:
DUF1075 (PF06388.14): Protein of unknown function (DUF1075) (124 a.a.), 24 papers
IPR009432: DUF1075. This family consists of several eukaryotic proteins of unknown function.
Members of DUF1075 whose function may be known:
DUF1425 (PF07233.15): Protein of unknown function (DUF1425) (92 a.a.), 24 papers
IPR010824: DUF1425. This family consists of several hypothetical bacterial proteins of around 125 residues in length. Several members of this family are described as putative lipoproteins and are often known as YcfL. The function of this family is unknown.
Overlapping families in CDD: DUF1425, YcfL
Members of DUF1425 whose function may be known:
DUF1706 (PF08020.14): Protein of unknown function (DUF1706) (166 a.a.), 24 papers
IPR012550: DUF1706. This family contains many hypothetical proteins from bacteria and yeast. Proteins in this entry include Irc4 (increased recombination centres 4) from budding yeast.
Overlapping families in CDD: DinB
Members of DUF1706 whose function may be known:
UPF0060 (PF02694.18): Uncharacterised BCR, YnfA/UPF0060 family (107 a.a.), 23 papers
IPR003844: UPF0060. This entry describes a family of integral membrane proteins. Some members of this family have been proposed to function as a thallium-specific efflux pump.
Overlapping families in CDD: PRK02237, YnfA
Members of UPF0060 whose function may be known:
DUF413 (PF04219.15): Protein of unknown function, DUF (90 a.a.), 23 papers
IPR007335: DUF413. This is a family of uncharacterised proteins.
Overlapping families in CDD: PRK11027, YifE
Members of DUF413 whose function may be known:
DUF945 (PF06097.14): Bacterial protein of unknown function (DUF945) (457 a.a.), 23 papers
IPR010352: DUF945. This entry consists of several hypothetical bacterial proteins of unknown function.
Overlapping families in CDD: PRK11367, YdgA
Members of DUF945 whose function may be known:
DUF2946 (PF11162.11): Protein of unknown function (DUF2946) (116 a.a.), 23 papers
IPR021333: DUF2946. This family of proteins has no known function.
Members of DUF2946 whose function may be known:
DUF5981 (PF12225.11): Methylene-tetrahydrofolate reductase C terminal (95 a.a.), 23 papers
IPR022026: MTHFR_C. This entry represents a domain of unknown function, which contains 8 conserved cysteine residues that might form a metal binding site.
Members of DUF5981 whose function may be known:
DUF4065 (PF13274.9): Protein of unknown function (DUF4065) (114 a.a.), 23 papers
IPR025272: DUF4065. This presumed domain is functionally uncharacterised.
Overlapping families in CDD: GepA
Members of DUF4065 whose function may be known:
DUF1387 (PF07139.14): Protein of unknown function (DUF1387) (307 a.a.), 22 papers
IPR009816: DUF1387. This family represents a conserved region approximately 300 residues long within a number of hypothetical proteins of unknown function that seem to be restricted to mammals.
Members of DUF1387 whose function may be known:
DUF1508 (PF07411.15): Domain of unknown function (DUF1508) (48 a.a.), 22 papers
IPR010879: DUF1508. This is a uncharacterised domain. This domain are often found as tandem repeats and in some cases represent the whole protein.
Overlapping families in CDD: YegP
Members of DUF1508 whose function may be known:
DUF2838 (PF10998.11): Protein of unknown function (DUF2838) (111 a.a.), 22 papers
IPR021261: GPCAT. Proteins in this family include glycerophosphocholine acyltransferase 1 (GPCAT). GPCAT homologues have been identified in most eukaryotes except chordates, but are not found in prokaryotes. GPCAT can acylate glycero-3-phosphocholine (GPC) with acyl groups from acyl-CoA. Thus it contributes to the maintenance of phosphatidylcholine (PC) homeostasis and may have specific functions in acyl editing of PC.
Members of DUF2838 whose function may be known:
DUF3237 (PF11578.11): Protein of unknown function (DUF3237) (149 a.a.), 22 papers
Overlapping families in CDD: PRK00872
Members of DUF3237 whose function may be known:
DUF3281 (PF11685.11): Protein of unknown function (DUF3281) (267 a.a.), 22 papers
IPR021699: DUF3281. This family of bacterial proteins has no known function. This entry includes bacterial lipoprotein FTN_103 from Francisella novicida.
Members of DUF3281 whose function may be known:
DUF3602 (PF12223.11): Protein of unknown function (DUF3602) (81 a.a.), 22 papers
IPR022024: DUF3602. This domain family is found in eukaryotes, and is typically between 78 and 89 amino acids in length. This entry include protein Par32 from Saccharomyces cerevisiae. Par32 is hyperphosphorylated after treatment with rapamycin in a TAP42-dependent manner. It is also involved in resistance to cisplatin.
Members of DUF3602 whose function may be known:
DUF92 (PF01940.19): Integral membrane protein DUF92 (236 a.a.), 21 papers
IPR002794: DUF92_TMEM19. Many members of this family have no known function and are predicted to be integral membrane proteins. One member of the family has been characterised as protein PGR (AtPGR). PGR is suggested to be a potential glucose-responsive regulator in carbohydrate metabolism in plants. This entry also includes protein VTE6, which is a Pphytyl-phosphate kinase catalyzing the conversion of phytyl-monophosphate...
Overlapping families in CDD: COG1836, TIGR00297
Members of DUF92 whose function may be known:
DUF463 (PF04317.15): YcjX-like family, DUF463 (440 a.a.), 21 papers
IPR007413: DUF463_YcjX. This family represents a group of uncharacterised proteins including a bacterial stress protein YcjX. The crystal structure of YcjX from Shewanella oneidensis has now been solved, and shows it to be a Ras-like GTP-binding protein. However, YcjX utilizes a non-canonical switch 2' motif not found in any other G protein.
Overlapping families in CDD: YcjX
Members of DUF463 whose function may be known:
DUF496 (PF04363.15): Protein of unknown function (DUF496) (93 a.a.), 21 papers
IPR007458: DUF496. Members of this family are uncharacterised proteins.
Overlapping families in CDD: PRK05423, YeeX
Members of DUF496 whose function may be known:
DUF632 (PF04782.15): Protein of unknown function (DUF632) (321 a.a.), 21 papers
IPR006867: DUF632. This conserved region contains a leucine zipper-like domain. The proteins are found only in plants and their functions are unknown.
Overlapping families in CDD: PRK13729
Members of DUF632 whose function may be known:
DUF630 (PF04783.15): Protein of unknown function (DUF630) (59 a.a.), 21 papers
IPR006868: DUF630. This region is sometimes found at the N terminus of putative plant bZIP proteins . The function of this conserved region is not known.
Overlapping families in CDD: PRK13729
Members of DUF630 whose function may be known:
DUF726 (PF05277.15): Protein of unknown function (DUF726) (343 a.a.), 21 papers
IPR007941: DUF726. This family consists of several uncharacterised eukaryotic proteins.
Members of DUF726 whose function may be known:
DUF1233 (PF06806.15): Putative excisionase (DUF1233) (70 a.a.), 21 papers
IPR009634: Put_exci. This family consists of several putative phage and prophage excisionase proteins of around 80 residues in length.
Members of DUF1233 whose function may be known:
DUF2418 (PF10332.12): Protein of unknown function (DUF2418) (96 a.a.), 21 papers
IPR018819: Nur1/Mug154. This entry includes Nur1 from budding yeasts and Mug154 from fission yeasts. Nur1 is part of the perinuclear network that controls recombination at multiple loci to maintain genome stability. Mug15 may has a role in meiosis.
Members of DUF2418 whose function may be known:
UPF0564 (PF10595.12): Uncharacterised protein family UPF0564 (364 a.a.), 21 papers
IPR019579: UPF0564. This entry represents proteins with no known function.
Overlapping families in CDD: PTZ00121
Members of UPF0564 whose function may be known:
DUF3713 (PF12506.11): Protein of unknown function (DUF3713) (116 a.a.), 21 papers
IPR022186: DUF3713. This family of proteins is found in bacteria. Proteins in this family are typically between 92 and 1225 amino acids in length. There is a single completely conserved residue S that may be functionally important.
Members of DUF3713 whose function may be known:
DUF406 (PF04175.15): Protein of unknown function (DUF406) (92 a.a.), 20 papers
IPR005272: CHP00743. These small proteins are approximately 100 amino acids in length and appear to be found only in gamma proteobacteria. The function of this protein family is unknown.
Overlapping families in CDD: PRK09981, TIGR00743, YfcZ
Members of DUF406 whose function may be known:
DUF423 (PF04241.18): Protein of unknown function (DUF423) (86 a.a.), 20 papers
IPR006696: DUF423. This is a potential integral membrane protein with no known function.
Overlapping families in CDD: PRK10873, YgdD
Members of DUF423 whose function may be known:
DUF935 (PF06074.15): Protein of unknown function (DUF935) (520 a.a.), 20 papers
IPR009279: DUF935. This family consists of several bacterial proteins of unknown function as well as the Bacteriophage Mu Gp29 protein .
Overlapping families in CDD: gp29
Members of DUF935 whose function may be known:
DUF1674 (PF07896.15): Protein of unknown function (DUF1674) (50 a.a.), 20 papers
IPR012875: SDHF4. This entry includes SDHF4 from animals, Sdh8 from budding yeasts and some uncharacterised proteins from bacteria. Sdh8 is required for assembly of succinate dehydrogenase (SDH). It interacts with the catalytic Sdh1 subunit in the mitochondrial matrix, facilitating its association with Sdh2 and the subsequent assembly of the SDH holocomplex.
Overlapping families in CDD: COG5508, YuxH
Members of DUF1674 whose function may be known:
DUF1735 (PF08522.13): Domain of unknown function (DUF1735) (123 a.a.), 20 papers
IPR013728: DUF1735. This domain of unknown function is found in a number of bacterial proteins including acylhydrolases.
Overlapping families in CDD: GH18_EndoS-like
Members of DUF1735 whose function may be known:
DUF1793 (PF08760.14): Domain of unknown function (DUF1793) (166 a.a.), 20 papers
IPR014870: DUF1793. This domain is found at the C terminus of Glutaminase A, an enzyme from Aspergillus that catalyses the hydrolysis of glutamine to glutamic acid and plays a key role in nitrogen metabolism. It is also found as a single domain protein in Bacteroides thetaiotaomicron.
Members of DUF1793 whose function may be known:
DUF2303 (PF10065.12): Uncharacterized conserved protein (DUF2303) (269 a.a.), 20 papers
IPR019276: DUF2303. Proteins in this entry are uncharacterised. The characteristics of the protein distribution suggest prophage matches in addition to the phage matches.
Overlapping families in CDD: yfdQ
Members of DUF2303 whose function may be known:
DUF2205 (PF10224.12): Short coiled-coil protein (75 a.a.), 20 papers
IPR019357: SCOC. This entry represents short coiled-coil protein (SCOC). In human, SCOC is required for autophagosome formation during amino acid starvation. It forms a starvation-sensitive trimeric complex with UVRAG (UV radiation resistance associated gene) and FEZ1 and may regulate ULK1 and Beclin 1 complex activities.
Members of DUF2205 whose function may be known:
DUF2520 (PF10728.12): Domain of unknown function (DUF2520) (127 a.a.), 20 papers
IPR018931: DUF2520. This presumed domain is found C-terminal to a Rossmann-like domain suggesting that these proteins are oxidoreductases.
Members of DUF2520 whose function may be known:
DUF3313 (PF11769.11): Protein of unknown function (DUF3313) (185 a.a.), 20 papers
IPR021747: DUF3313. This a bacterial family of proteins which are annotated as putative lipoproteins.
Members of DUF3313 whose function may be known:
DUF3367 (PF11847.11): Alpha-(1->3)-arabinofuranosyltransferase (664 a.a.), 20 papers
IPR021798: AftD. Alpha-(1->3)-arabinofuranosyltransferase is involved in the biosynthesis of the arabinogalactan (AG) region of the mycolylarabinogalactan-peptidoglycan (mAGP) complex, an essential component of the mycobacterial cell wall. It catalyzes the addition of an arabinofuranosyl (Araf) residue from the sugar donor decaprenyl-phospho-arabinose (DPA) on the C-3 of an alpha-(1->5)-linked Araf from the arabinan backbone of AG.
Members of DUF3367 whose function may be known:
DUF3611 (PF12263.11): Protein of unknown function (DUF3611) (175 a.a.), 20 papers
IPR022051: DUF3611. This entry represents a group of proteins mostly from plants and Cyanobacteria (blue-green algae), including TIC21 from Arabidopsis. TIC21 is Involved in chloroplast protein import across the inner envelope membrane. It can acts as a chloroplast permease regulating the iron transport and homeostasis.
Members of DUF3611 whose function may be known:
DUF3677 (PF12432.11): Protein of unknown function (DUF3677) (82 a.a.), 20 papers
IPR022145: DUF3677. This domain of unknown function is found in metazoan proteins. It is found in the subunit 1 of the Integrator complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing.
Members of DUF3677 whose function may be known:
DUF4200 (PF13863.9): Domain of unknown function (DUF4200) (119 a.a.), 20 papers
IPR025252: DUF4200. This entry represents a coiled-coil domain. Its function is unknown.
Overlapping families in CDD: COG5022, SMC_prok_B, SbcC, Smc
Members of DUF4200 whose function may be known:
DUF4965 (PF16335.8): Domain of unknown function (DUF4965) (174 a.a.), 20 papers
IPR032514: DUF4965. This domain can be found in Glutaminase A, an enzyme from Aspergillus that catalyses the hydrolysis of glutamine to glutamic acid and plays a key role in nitrogen metabolism. The function of this domain is unknown.
Members of DUF4965 whose function may be known:
DUF5127 (PF17168.7): Domain of unknown function (DUF5127) (227 a.a.), 20 papers
IPR033433: DUF5127. This domain is found towards the N terminus of Glutaminase A, an enzyme from Aspergillus that catalyzes the hydrolysis of glutamine to glutamic acid and plays a key role in nitrogen metabolism.
Members of DUF5127 whose function may be known:
DUF421 (PF04239.15): Protein of unknown function (DUF421) (109 a.a.), 19 papers
IPR007353: DUF421. This family of uncharacterised proteins is known as YDFR family
Overlapping families in CDD: YcaP
Members of DUF421 whose function may be known:
DUF1090 (PF06476.15): Protein of unknown function (DUF1090) (110 a.a.), 19 papers
IPR009468: DUF1090. This family consists of several bacterial proteins of unknown function and is known as YqjC in Escherichia coli.
Members of DUF1090 whose function may be known:
DUF1266 (PF06889.14): Protein of unknown function (DUF1266) (177 a.a.), 19 papers
IPR009677: DUF1266. This family consists of several hypothetical bacterial proteins of unknown function.
Overlapping families in CDD: PRK11380
Members of DUF1266 whose function may be known:
UPF0300 (PF08594.13): Uncharacterised protein family (UPF0300) (212 a.a.), 19 papers
IPR013903: Meiotic_expression. This family of proteins appear to be specific to Schizosaccharomyces (Fission yeast). Their exact function is unknown, but they are up-regulated in meiosis and some of them have been shown to be required for critical meiotic events.
Members of UPF0300 whose function may be known:
DUF2502 (PF10697.12): Protein of unknown function (DUF2502) (90 a.a.), 19 papers
IPR019638: DUF2502. This entry represents proteins mainly found in Gammaproteobacteria. The function is not known.
Members of DUF2502 whose function may be known:
DUF2776 (PF10951.11): Protein of unknown function (DUF2776) (348 a.a.), 19 papers
IPR021240: DUF2776. This bacterial family of proteins has no known function.
Members of DUF2776 whose function may be known:
DUF3029 (PF11230.11): Protein of unknown function (DUF3029) (485 a.a.), 19 papers
IPR016905: Glycyl_radical_HI0521_prd. Members of this family are homologues to enzymes known to undergo activation by a radical SAM protein to create an active site glycyl radical. This family appears to be activated by the YjjW radical SAM protein, usually encoded by an adjacent gene.
Overlapping families in CDD: PRK10977, glycyl_YjjI
Members of DUF3029 whose function may be known:
DUF3053 (PF11254.11): Protein of unknown function (DUF3053) (220 a.a.), 19 papers
IPR021413: DUF3053. Some members in this family of proteins are annotated as the membrane protein YiaF. No function is currently known.
Members of DUF3053 whose function may be known:
DUF4112 (PF13430.9): Domain of unknown function (DUF4112) (105 a.a.), 19 papers
IPR025187: DUF4112. This uncharacterised protein family has several highly conserved GD sequence-motifs of unknown function.
Members of DUF4112 whose function may be known:
DUF4156 (PF13698.9): Domain of unknown function (DUF4156) (90 a.a.), 19 papers
IPR025294: DUF4156. The function of this family is unknown but some members are annotated as putative lipoprotein outer membrane proteins.
Members of DUF4156 whose function may be known:
DUF4188 (PF13826.9): Domain of unknown function (DUF4188) (118 a.a.), 19 papers
IPR025444: Monooxy_af470. This family consists of proteins from bacteria and fungi. It includes monooxygenase af470 from Aspergillus fumigatus, which is part of the fma gene cluster that mediates the biosynthesis of fumagillin, a meroterpenoid with numerous biological activities. It has been suggested that af470 mediates the oxidative cleavage of the terminal alkene of the dodecapentaenoate side chain into the carboxylic acid...
Members of DUF4188 whose function may be known:
DUF1190 (PF06693.14): Protein of unknown function (DUF1190) (163 a.a.), 18 papers
IPR009576: Biofilm_formation_YgiB. The proteins in this entry, which include YgiB, are functionally uncharacterised, however, transcription of ygiB is induced upon biofilm formation compared to planktonic growth in both exponential and stationary phase. Induction of expression was found to be dependent on the presence of the F plasmid. Biofilm formation is impaired in mutants of ygiB.
Overlapping families in CDD: PHA02118, PRK11653, YgiB
Members of DUF1190 whose function may be known:
DUF1397 (PF07165.14): Protein of unknown function (DUF1397) (207 a.a.), 18 papers
IPR009832: DUF1397. This entry consists of several insect specific 27kDa Haemolymph glycoprotein precursors. The function of this family is unknown.
Members of DUF1397 whose function may be known:
DUF1435 (PF07256.15): Protein of unknown function (DUF1435) (75 a.a.), 18 papers
IPR009885: DUF1435. This family consists of several hypothetical Enterobacterial proteins of around 80 residues in length. The function of this family is unknown.
Members of DUF1435 whose function may be known:
DUF1689 (PF07954.14): Protein of unknown function (DUF1689) (146 a.a.), 18 papers
IPR012470: Pup1-like. This entry represents a group of fungal proteins, including Pup1 from Candida glabrata. Pup1 is a mitochondrial protein that contributes to the enhanced virulence of C.glabrata strains that acquired azole resistance.
Members of DUF1689 whose function may be known:
DUF1690 (PF07956.14): Protein of Unknown function (DUF1690) (139 a.a.), 18 papers
IPR012471: DUF1690. Family of uncharacterised fungal proteins.
Members of DUF1690 whose function may be known:
DUF2420 (PF10336.12): Protein of unknown function (DUF2420) (108 a.a.), 18 papers
IPR018822: UPF0646. This entry represents a family of proteins conserved in fungi. Their function is not known.
Members of DUF2420 whose function may be known:
DUF4668 (PF15701.8): Domain of unknown function (DUF4668) (162 a.a.), 18 papers
IPR031427: DUF4668. This family of proteins is found in fungi. Proteins in this family are typically between 142 and 211 amino acids in length.
Members of DUF4668 whose function may be known:
DUF5351 (PF17302.5): Family of unknown function (DUF5351) (29 a.a.), 18 papers
IPR035272: DUF5351. This family of unknown function is found in Bacillales.
Overlapping families in CDD: DnaJ_zf, PLN03165, PRK14276, PRK14279, PRK14280, PRK14281, PRK14293, PRK14295, PRK14296, PRK14297, PRK14298
Members of DUF5351 whose function may be known:
DUF383 (PF04063.17): Domain of unknown function (DUF383) (188 a.a.), 17 papers
IPR007205: Protein_HGH1_N. This entry represents a domain within Protein HGH1, of unknown function. It is found N-terminal to another domain of unknown function ( ).
Members of DUF383 whose function may be known:
DUF1161 (PF06649.15): Protein of unknown function (DUF1161) (52 a.a.), 17 papers
IPR010595: DUF1161. This family consists of several short, hypothetical bacterial proteins of unknown function.
Members of DUF1161 whose function may be known:
DUF1414 (PF07208.14): Protein of unknown function (DUF1414) (44 a.a.), 17 papers
IPR009857: UPF0352. This family consists of several hypothetical bacterial proteins of around 70 residues in length. Members of this family are often referred to as YejL. The function of this family is unknown.
Overlapping families in CDD: PRK13689, YejL
Members of DUF1414 whose function may be known:
DUF1451 (PF07295.14): Zinc-ribbon containing domain (147 a.a.), 17 papers
IPR009912: DUF1451. This family consists of several hypothetical bacterial proteins of around 160 residues in length. Members of this family contain four highly conserved cysteine resides toward the C-terminal region of the protein.
Overlapping families in CDD: PRK11032
Members of DUF1451 whose function may be known:
DUF1480 (PF07351.16): Protein of unknown function (DUF1480) (78 a.a.), 17 papers
IPR009950: DUF1480. This family consists of several hypothetical Enterobacterial proteins of around 80 residues in length. The function of this family is unknown.
Members of DUF1480 whose function may be known:
DUF1749 (PF08538.13): Protein of unknown function (DUF1749) (299 a.a.), 17 papers
IPR013744: SidJ. This entry includes fusarinine C esterase SidJ from the yeast Neosartorya fumigata . Fusarinine C is an intracellular siderophore (an iron-chelating compound that transports iron across membranes) that is crucial for virulence. The closely related siderophore triacetylfusarinine C is not hydrolysed by SidJ. Homologues of SidJ are found in plants and bacteria.
Members of DUF1749 whose function may be known:
DUF2263 (PF10021.12): Uncharacterized protein conserved in bacteria (DUF2263) (146 a.a.), 17 papers
IPR019261: DUF2263. This domain, found in various hypothetical bacterial and eukaryotic proteins, has no known function.
Overlapping families in CDD: COG4295, TIGR02452
Members of DUF2263 whose function may be known:
KxDL (PF10241.12): Uncharacterized conserved protein (86 a.a.), 17 papers
IPR019371: Uncharacterised_KxDL. This entry represents a conserved region of 80 residues which defines a family of short proteins. There is a characteristic KxDL motif towards the C terminus. The function is unknown.
Members of KxDL whose function may be known:
DUF3310 (PF11753.11): Protein of unknwon function (DUF3310) (60 a.a.), 17 papers
IPR021739: SaV-like. This entry includes bacteriophage T7, Gp1.7, which is a nucleotide kinase that catalyzes the phosphorylation of dGMP and dTMP to dGDP and dTDP. It also includes SaV from Lactococcus phage p2, which is involved in sensitivity to the host abortive infection mechanism AbiV. The characteristics of the protein distribution suggest prophage matches in addition to the phage matches.
Members of DUF3310 whose function may be known:
DUF3373 (PF11853.11): Protein of unknown function (DUF3373) (409 a.a.), 17 papers
IPR021803: DUF3373. This family of proteins are functionally uncharacterised. This protein is found in bacteria. Proteins in this family are typically between 472 to 574 amino acids in length.
Members of DUF3373 whose function may be known:
DUF3464 (PF11947.11): Photosynthesis affected mutant 68 (150 a.a.), 17 papers
IPR021855: PAM68-like. This entry includes chloroplastic protein PAM68 and some uncharacterised proteins from Cyanobacteria (blue-green algae). PAM68 is involved in early steps in photosystem II (PSII) biogenesis and in maturation and stability of newly synthesized psbA protein.
Members of DUF3464 whose function may be known:
DUF4422 (PF14393.9): Domain of unknown function (DUF4422) (225 a.a.), 17 papers
IPR025536: DUF4422. This is a conserved domain found in deubiquitinating enzymes, MINDY-3 and MINDY-4.
Members of DUF4422 whose function may be known:
UPF0515 (PF15135.9): Uncharacterised protein UPF0515 (271 a.a.), 17 papers
IPR026795: SHFL. This family describes shiftless antiviral inhibitor of ribosomal frameshifting protein (SHFL). SHFL has been shown to inhibit programmed -1 ribosomal frameshifting (-1PRF) in a variety of mRNAs from viruses (for example HIV1 GAG-POL) as well as cellular genes. SHFL is also known as repressor of yield of DENV (RyDEN), and has been identified as a interferon-stimulated cellular inhibitor against...
Members of UPF0515 whose function may be known:
DUF668 (PF05003.15): Protein of unknown function (DUF668) (89 a.a.), 16 papers
IPR007700: DUF668. This entry represents the C-terminal domain of PSI proteins from Arabidopsis. This domain is found associated with DUF3475 ( ). PSI1 was identified as a gene that is co-expressed with the phytosulfokine (PSK) receptor genes PSKR1 and PSKR2 in Arabidopsis thaliana. PSI proteins are plant-specific and promote growth.
Members of DUF668 whose function may be known:
DUF1315 (PF07023.15): Protein of unknown function (DUF1315) (82 a.a.), 16 papers
IPR009749: DUF1315. This family consists of several bacterial proteins of around 90 residues in length. The function of this family is unknown.
Overlapping families in CDD: yeaC
Members of DUF1315 whose function may be known:
DUF2043 (PF09740.12): Uncharacterized conserved protein (DUF2043) (106 a.a.), 16 papers
IPR018610: UVSSA. UVSSA is part of a UV-induced ubiquitinated protein complex involved in transcription-coupled nucleotide excision repair (TC-NER) in response to UV damage. It stabilise the TC-NER master organizing protein ERCC6 (also known as CSB) by delivering the deubiquitinating enzyme USP7 to TC-NER complexes.
Members of DUF2043 whose function may be known:
DUF2207 (PF09972.12): Predicted membrane protein (DUF2207) (483 a.a.), 16 papers
IPR018702: DUF2207_membrane. This domain has no known function.
Members of DUF2207 whose function may be known:
Ycf54 (PF10674.12): Protein of unknown function (DUF2488) (92 a.a.), 16 papers
IPR019616: Ycf54. Ycf54 is found encoded in the chloroplast genomes of algae, it is also found in plants and in the cyanobacteria. Ycf54 is a component of the MgPME-cyclase complex. Ycf54 plays two roles in the function of the MgPME-cyclase. First, it plays a critical role in t assembly/stability of the Mg-cyclase complex and its constituents and, secondly, is required for...
Members of Ycf54 whose function may be known:
DUF3251 (PF11622.11): Protein of unknown function (DUF3251) (165 a.a.), 16 papers
IPR021658: DUF3251. This entry represents a domain found in a group of bacterial lipoproteins, such as SadB from Salmonella typhimurium. SadB is required for proper surface expression of the autotransporter adhesin SadA.
Members of DUF3251 whose function may be known:
DUF3419 (PF11899.11): Protein of unknown function (DUF3419) (385 a.a.), 16 papers
IPR021829: DUF3419. This family of proteins are functionally uncharacterised. This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 398 to 802 amino acids in length.
Overlapping families in CDD: BtaA
Members of DUF3419 whose function may be known:
DUF3475 (PF11961.11): Domain of unknown function (DUF3475) (57 a.a.), 16 papers
IPR021864: DUF3475. This entry represents the N-terminal domain of PSI proteins from Arabidopsis. This domain is found associated with DUF668 ( ). PSI1 was identified as a gene that is co-expressed with the phytosulfokine (PSK) receptor genes PSKR1 and PSKR2 in Arabidopsis thaliana. PSI proteins are plant-specific and promote growth.
Members of DUF3475 whose function may be known:
DUF3828 (PF12883.10): Protein of unknown function (DUF3828) (122 a.a.), 16 papers
IPR024289: DUF3828. This domain currently has no known function.
Overlapping families in CDD: PRK10533
Members of DUF3828 whose function may be known:
GLTSCR1 (PF15249.9): Conserved region of unknown function on GLTSCR protein (102 a.a.), 16 papers
IPR015671: GSCR1_dom. This domain is found in glioma tumour suppressor candidate region gene 1 (GLTSCR1) protein, and is typically between 105 and 124 amino acids in length. There is a single completely conserved residue F that may be functionally important. Mutations in the gene for this protein in humans leads to the development of oligodendrogliomas. There is evidence that these protein...
Overlapping families in CDD: PHA03247, PRK12323, PRK14951, gliding_GltJ
Members of GLTSCR1 whose function may be known:
DUF502 (PF04367.16): Protein of unknown function (DUF502) (106 a.a.), 15 papers
IPR007462: COV1-like. This entry includes COV1 from Arabidopsis and uncharacterised proteins from bacteria and archaea. COV1 is an integral membrane protein involved in the regulation of vascular patterning in the stem, probably by negatively regulating the differentiation of vascular tissue.
Overlapping families in CDD: COG2928
Members of DUF502 whose function may be known:
DUF616 (PF04765.16): Protein of unknown function (DUF616) (314 a.a.), 15 papers
IPR006852: DUF616. The entry represents a protein of unknown function. The function of is unknown although a number of the members are thought to be glycosyltransferases. Proteins in this entry includes MUCI70 from Arabidopsis. MUCI70 is a predicted glycosyltransferase essential for the accumulation of seed mucilage, a gelatinous wall rich in unbranched rhamnogalacturonan I (RG I), and for shaping the surface...
Members of DUF616 whose function may be known:
DUF678 (PF05077.15): Protein of unknown function (DUF678) (75 a.a.), 15 papers
IPR007769: Poxvirus_A19. This family contains poxvirus proteins belonging to the A19 family. The proteins are of unknown function.
Overlapping families in CDD: PHA02893
Members of DUF678 whose function may be known:
DUF1097 (PF06496.14): Protein of unknown function (DUF1097) (146 a.a.), 15 papers
IPR009476: DUF1097. This family consists of several bacterial putative membrane proteins, including inner membrane protein YcdZ ( ) from Salmonella typhimurium.
Members of DUF1097 whose function may be known:
DUF1289 (PF06945.16): Protein of unknown function (DUF1289) (48 a.a.), 15 papers
IPR010710: DUF1289. This family consists of a number of hypothetical bacterial proteins. The aligned region spans around 56 residues and contains 4 highly conserved cysteine residues towards the N terminus. The function of this family is unknown.
Overlapping families in CDD: YdhL
Members of DUF1289 whose function may be known:
DUF1482 (PF07358.14): Protein of unknown function (DUF1482) (57 a.a.), 15 papers
IPR009954: DUF1482. This family consists of several Enterobacterial proteins of around 60 residues in length. The function of this family is unknown.
Members of DUF1482 whose function may be known:
DUF1968 (PF09291.13): Domain of unknown function (DUF1968) (81 a.a.), 15 papers
IPR015370: TCR_alpha_C. This entry represents the constant domain of the alpha chain of alpha/beta T-cell antigen receptors (TCRs). TCRs mediate antigen recognition by T lymphocytes, and are composed of alpha and beta, or gamma and delta, polypeptide chains with variable (V) and constant (C) regions. Alpha/beta TCRs recognize antigen as peptide fragments presented by major histocompatibility complex (MHC) molecules. The antigen...
Overlapping families in CDD: IgC_TCR_alpha
Members of DUF1968 whose function may be known:
DUF2053 (PF09767.12): Predicted membrane protein (DUF2053) (160 a.a.), 15 papers
IPR019164: TMEM147. TMEM147 is a component of the Nicalin-NOMO protein complex, which catalyzes the proteolytic cleavage of the transmembrane domain of various proteins including the beta-amyloid precursor protein and Notch.
Members of DUF2053 whose function may be known:
DUF2464 (PF10240.12): Multivesicular body subunit 12 (255 a.a.), 15 papers
IPR018798: MVB12A/B. MVB12A (also known as CFBP) and MVB12B are subunits of the ESCRT-I complex, which mediates the sorting of ubiquitinated cargo protein from the plasma membrane to the endosomal vesicle. MVB12A plays a key role in the ligand-mediated internalization and down-regulation of the EGF receptor.
Members of DUF2464 whose function may be known:
DUF5427 (PF10310.12): Family of unknown function (DUF5427) (463 a.a.), 15 papers
IPR018814: DUF5427. In Saccharomyces cerevisiae, maintenance of telomere capping protein 1 (Mtc1) may interact with ribosomes and is synthetically lethal with cdc13-1 .
Members of DUF5427 whose function may be known:
DUF2527 (PF10736.12): Protein of unknown function (DUF2627) (38 a.a.), 15 papers
IPR019672: DUF2527. This entry represents small proteins with unknown function and appear to be restricted to a family of Enterobacterial proteins. It has a highly conserved sequence. Some proteins are annotated as YobF and may be involved in stress responses in E. coli.
Members of DUF2527 whose function may be known:
DUF2877 (PF11392.11): Protein of unknown function (DUF2877) (109 a.a.), 15 papers
IPR021530: DUF2877. This bacterial family of proteins are putative carboxylase proteins however this cannot be confirmed.
Members of DUF2877 whose function may be known:
DUF3987 (PF13148.9): Protein of unknown function (DUF3987) (366 a.a.), 15 papers
IPR025048: DUF3987. This entry represents a family of uncharacterised proteins that was originally found by clustering human gut metagenomic sequences.
Members of DUF3987 whose function may be known:
DUF4731 (PF15875.8): Domain of unknown function (DUF4731) (75 a.a.), 15 papers
IPR031744: SMIM1. SMIM1 is a small integral membrane protein that regulates red blood cell formation. The Vel blood group antigen is expressed on the red blood cells of most individuals. SMIM1 has been shown to encode the Vel blood group antigen.
Members of DUF4731 whose function may be known:
DUF4772 (PF15997.8): Domain of unknown function (DUF4772) (118 a.a.), 15 papers
IPR031940: DUF4772. This presumed domain is functionally uncharacterised. This domain is found in eukaryotes, and is typically between 107 and 124 amino acids in length. There is a single completely conserved residue V that may be functionally important.
Members of DUF4772 whose function may be known:
DUF440 (PF04269.15): Protein of unknown function, DUF440 (101 a.a.), 14 papers
IPR007376: dsDNA_mimic_put. This entry represents hypothetical proteins such as HI1450, which is believed to act as a putative dsDNA mimic. HI1450 is an acidic protein with a core structure consisting of alpha(2)-beta(4), where the alpha-helices are packed against the side of an anti-parallel 4-stranded beta meander. As such, it has some similarity to the dsDNA mimics uracil-DNA glycosylase inhibitor and nuclease...
Overlapping families in CDD: PRK05094, YciU
Members of DUF440 whose function may be known:
DUF489 (PF04356.15): Protein of unknown function (DUF489) (192 a.a.), 14 papers
IPR007451: HflD. When bacteriophage lambda infects to the Escherichia coli cell, it undergoes either lytic growth or lysogenization. The lambda CII protein is a key determinant in the lysis-lysogeny decision. Escherichia coli HflD is a factor that may sequesters CII from the target promoters and recruits it to the membrane where the FtsH protease is localized.
Overlapping families in CDD: HflD, PRK00218
Members of DUF489 whose function may be known:
DUF740 (PF05340.15): Protein of unknown function (DUF740) (625 a.a.), 14 papers
IPR008004: OCTOPUS-like. This family consists of several plant proteins, including protein OCTOPUS (OPS, At3g09070) and OPSL1 (At5g01170) from Arabidopsis. OPS is a membrane-associated protein that regulates phloem differentiation entry. It is a positive regulator of the brassinosteroid (BR) signaling pathway and sequesters BIN2 to the plasma membrane to promote phloem differentiation.
Members of DUF740 whose function may be known:
DUF932 (PF06067.14): Domain of unknown function (DUF932) (228 a.a.), 14 papers
IPR026325: DUF932. This entry represents a family of prokaryotic proteins with unknown function. They contain a number of highly conserved polar residues that could suggest an enzymatic activity.
Members of DUF932 whose function may be known:
DUF1176 (PF06674.14): Protein of unknown function (DUF1176) (327 a.a.), 14 papers
IPR009560: DUF1176. This family consists of several hypothetical bacterial proteins of around 340 residues in length. Members of this family contain six highly conserved cysteine residues. The function of this family is unknown.
Members of DUF1176 whose function may be known:
DUF1242 (PF06842.15): Protein of unknown function (DUF1242) (35 a.a.), 14 papers
IPR009653: Ksh1. Protein kish is involved in the early part of the secretory pathway.
Members of DUF1242 whose function may be known:
DUF1746 (PF08508.13): Fungal domain of unknown function (DUF1746) (115 a.a.), 14 papers
IPR013715: DUF1746. This is a fungal domain of unknown function. This domain can be found in DSC E3 ubiquitin ligase complex subunit 4 (Dsc4) from S. pombe. It is a component of the DSC E3 ubiquitin ligase complex required for the sre1 transcriptional activator proteolytic cleavage to release the soluble transcription factor from the membrane in low oxygen or sterol conditions....
Members of DUF1746 whose function may be known:
DUF1869 (PF08956.13): Domain of unknown function (DUF1869) (59 a.a.), 14 papers
IPR015051: YoaG. This entry represents a group of uncharacterised bacterial proteins.
Members of DUF1869 whose function may be known:
DUF2034 (PF10356.12): Protein of unknown function (DUF2034) (185 a.a.), 14 papers
IPR018828: DUF2034. This protein is expressed mainly in fungi but its function is unknown.
Members of DUF2034 whose function may be known:
DUF2514 (PF10721.12): Protein of unknown function (DUF2514) (161 a.a.), 14 papers
IPR019659: DUF2514. This protein family is conserved in bacteria and some viruses. The function is not known. This entry includes the protein gp55 from Enterobacteria phage N15.
Members of DUF2514 whose function may be known:
DUF2541 (PF10807.11): Protein of unknown function (DUF2541) (130 a.a.), 14 papers
IPR020240: UPF0412_YaaI. This entry represents proteins found in the Gammaproteobacteria that have no known function.
Overlapping families in CDD: PRK10154
Members of DUF2541 whose function may be known:
DUF2884 (PF11101.11): Protein of unknown function (DUF2884) (228 a.a.), 14 papers
IPR021307: DUF2884. Some members in this bacterial family of proteins are annotated as YggN which currently has no known function.
Overlapping families in CDD: PRK10626
Members of DUF2884 whose function may be known:
DUF4043 (PF13252.9): Protein of unknown function (DUF4043) (386 a.a.), 14 papers
IPR025267: DUF4043. This family of proteins is functionally uncharacterised. There is a single completely conserved residue G that may be functionally important. Proteins in this entry include major structural protein ORF14 from Helicobacter pylori bacteriophage KHP30 and ORF017 from Pseudomonas phage KPP25.
Overlapping families in CDD: capsid_maj_N4
Members of DUF4043 whose function may be known:
TPD (PF14811.9): Protein of unknown function TPD sequence-motif (138 a.a.), 14 papers
IPR029404: CDIN1. This is a family of proteins includes CDIN1 from human, and homologues. CDIN1 is thought to play a role in erythroid cell differentiation. Some family members have an associated zinc-finger domain. All members carry a highly conserved TPD sequence-motif.
Members of TPD whose function may be known:
CTP-dep_RFKase (PF01982.19): Domain of unknown function DUF120 (121 a.a.), 13 papers
IPR023602: Riboflavin_kinase_CTP-dep. Riboflavin is converted into catalytically active cofactors (FAD and FMN) by the actions of riboflavin kinase ( ), which converts it into FMN, and FAD synthetase ( ), which adenylates FMN to FAD. Eukaryotes usually have two separate enzymes, while most prokaryotes have a single bifunctional protein that can carry out both catalyses, although exceptions occur in both cases....
Overlapping families in CDD: PRK14132, PRK14165, Rfk
Members of CTP-dep_RFKase whose function may be known:
DUF446 (PF04287.15): tRNA pseudouridine synthase C (98 a.a.), 13 papers
IPR023376: YqcC-like_dom. This entry represents the structural domain found in the N-terminal of some tRNA pseudouridine synthase C proteins, as well as other uncharacterised proteins.
Overlapping families in CDD: YqcC
Members of DUF446 whose function may be known:
DUF452 (PF04301.16): Protein of unknown function (DUF452) (213 a.a.), 13 papers
IPR007398: DUF452. This is a family of uncharacterised proteins.
Overlapping families in CDD: COG2830
Members of DUF452 whose function may be known:
DUF484 (PF04340.15): Protein of unknown function, DUF484 (225 a.a.), 13 papers
IPR007435: DUF484. This family consists of several proteins of uncharacterised function.
Overlapping families in CDD: PRK10963, YigA
Members of DUF484 whose function may be known:
DUF641 (PF04859.15): Plant protein of unknown function (DUF641) (128 a.a.), 13 papers
IPR006943: DUF641_pln. This conserved region is found in a number of plant proteins of unknown function.
Members of DUF641 whose function may be known:
UPF0240 (PF06784.14): Uncharacterised protein family (UPF0240) (168 a.a.), 13 papers
IPR009622: NDUFAF4. NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4 (NDUFAF4, also known as HRPAP20) is involved in the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I). It may be involved in cell proliferation and survival of hormone-dependent tumor cells.
Members of UPF0240 whose function may be known:
DUF1327 (PF07041.14): Protein of unknown function (DUF1327) (113 a.a.), 13 papers
IPR009759: Phage_ES18_Gp24. This family consists of several hypothetical bacterial proteins of around 115 residues in length, which seem to be specific to Escherichia coli. The function of this family is unknown. This entry is represented by Bacteriophage ES18, Gp24. The characteristics of the protein distribution suggest prophage matches in addition to the phage matches.
Members of DUF1327 whose function may be known:
DUF1496 (PF07383.15): Protein of unknown function (DUF1496) (53 a.a.), 13 papers
IPR009971: DUF1496. This family consists of several bacterial proteins of around 90 residues in length. Members of this family seem to be found exclusively in the Orders Vibrionales and Enterobacteriales. The function of this family is unknown.
Members of DUF1496 whose function may be known:
DUF1654 (PF07867.14): Protein of unknown function (DUF1654) (70 a.a.), 13 papers
IPR012449: Phage_F116_Orf28. This family consists of proteins from the Pseudomonadaceae. This entry is represented by Bacteriophage F116 (Pseudomonas phage F116), Orf28. The characteristics of the protein distribution suggest prophage matches in addition to the phage matches.
Members of DUF1654 whose function may be known:
DUF1864 (PF08933.14): Domain of unknown function (DUF1864) (387 a.a.), 13 papers
IPR015029: DUF1864. This protein has no known function. It is found in various hypothetical and conserved domain proteins.
Members of DUF1864 whose function may be known:
DUF2368 (PF10166.12): Uncharacterised conserved protein (DUF2368) (134 a.a.), 13 papers
IPR019319: Plg-R(KT). Plg-R(KT) is a receptor for plasminogen and is involved in the plasminogen-dependent regulation of macrophage invasion, chemotactic migration, and recruitment in the inflammatory response. It is essential for mammary lobuloalveolar development and lactation.
Members of DUF2368 whose function may be known:
DUF2408 (PF10303.12): Protein of unknown function (DUF2408) (134 a.a.), 13 papers
IPR018810: UPF0662. This entry represents a family of proteins conserved in fungi whose function is unknown. It includes Cu(2+) suppressing and bleomycin sensitive protein 1 thought to be involved in bleomycin tolerance with links to DNA repair and/or proteasome function.
Members of DUF2408 whose function may be known:
DUF3605 (PF12239.11): Protein of unknown function (DUF3605) (154 a.a.), 13 papers
IPR022036: DUF3605. This family of proteins is found mostly in fungi, including N-acetylglucosamine-induced protein 1 (Gig1) from Candida albicans. Gig1 plays a role in the N-acetylglucosamine metabolic pathway.
Members of DUF3605 whose function may be known:
DUF4408 (PF14364.9): Domain of unknown function (DUF4408) (33 a.a.), 13 papers
IPR025520: DUF4408. This domain of unknown function is found at the N-terminal of the pathogen-associated molecular patterns-induced protein A70 from Arabidopsis thaliana and other plant proteins.
Members of DUF4408 whose function may be known:
DUF350 (PF03994.17): Domain of Unknown Function (DUF350) (54 a.a.), 12 papers
IPR007140: DUF350. This motif occurs in a small set of bacterial proteins. It has two transmembrane regions, and often occurs as tandem repeats. The are no conserved catalytic residues.
Overlapping families in CDD: YjfL
Members of DUF350 whose function may be known:
DUF374 (PF04028.16): Domain of unknown function (DUF374) (69 a.a.), 12 papers
IPR007172: DUF374. This is a bacterial domain of unknown function.
Overlapping families in CDD: COG2121, LPLAT_DUF374-like
Members of DUF374 whose function may be known:
DUF384 (PF04064.16): Domain of unknown function (DUF384) (55 a.a.), 12 papers
IPR007206: Protein_HGH1_C. This entry represents a domain within Protein HGH1, of unknown function. It is found C-terminal to another domain of unknown function ( ).
Members of DUF384 whose function may be known:
DUF418 (PF04235.15): Protein of unknown function (DUF418) (163 a.a.), 12 papers
IPR007349: DUF418. This domain of unknown function is found in probable integral membrane proteins.
Overlapping families in CDD: PRK10835, YeiB
Members of DUF418 whose function may be known:
DUF617 (PF04759.16): Protein of unknown function, DUF617 (161 a.a.), 12 papers
IPR006460: MIZ1-like_pln. This entry includes Arabidopsis MIZU-KUSSEI 1 (MIZ1), which is an essential protein for hydrotropism in roots. It can be regulated by light signal and ABA signalling.
Overlapping families in CDD: A_thal_3588
Members of DUF617 whose function may be known:
DUF898 (PF05987.16): Bacterial protein of unknown function (DUF898) (343 a.a.), 12 papers
IPR010295: DUF898. This family consists of several bacterial proteins of unknown function. Some of the family, including YjgN, are putative transmembrane proteins.
Overlapping families in CDD: YjgN
Members of DUF898 whose function may be known:
DUF1040 (PF06288.16): Protein of unknown function (DUF1040) (86 a.a.), 12 papers
IPR009383: DUF1040. This family consists of several bacterial YihD proteins of unknown function.
Overlapping families in CDD: YihD
Members of DUF1040 whose function may be known:
DUF1187 (PF06688.14): Protein of unknown function (DUF1187) (61 a.a.), 12 papers
IPR009572: DUF1187. This family consists of several short, hypothetical bacterial proteins of around 62 residues in length. Members of this family are found in Escherichia coli and Salmonella typhi. The function of this family is unknown.
Overlapping families in CDD: PRK09750
Members of DUF1187 whose function may be known:
DUF1391 (PF07151.15): Protein of unknown function (DUF1391) (48 a.a.), 12 papers
IPR009821: DUF1391. This family consists of several Enterobacterial proteins of around 50 residues in length. Members of this family are found in Escherichia coli and Salmonella typhi where they are often known as YdfA. The function of this family is unknown.
Members of DUF1391 whose function may be known:
DUF1615 (PF07759.15): Protein of unknown function (DUF1615) (320 a.a.), 12 papers
IPR011673: DUF1615. This is a family of proteins of unknown function expressed by various bacterial species. Some members of this family (e.g. , ) are thought to be lipoproteins. Another member of this family ( ) is thought to be involved in photosynthesis.
Members of DUF1615 whose function may be known:
DUF1773 (PF08593.13): Domain of unknown function (58 a.a.), 12 papers
IPR013902: DUF1773. This entry represents a conserved domain found in certain meiotically up-regulated gene products (MUG) from fungi. The actual function is not yet known. The proteins are likely to be cell-surface glycoproteins and may be situated close to telomeres, hence their being expressed during meiosis.
Overlapping families in CDD: PRK00106, PRK12704, PTZ00121, SMC_prok_B
Members of DUF1773 whose function may be known:
DUF2058 (PF09831.12): Uncharacterized protein conserved in bacteria (DUF2058) (174 a.a.), 12 papers
IPR018636: DUF2058. This family, found in various prokaryotic proteins, has no known function.
Overlapping families in CDD: YaiL
Members of DUF2058 whose function may be known:
DUF2170 (PF09938.12): Uncharacterized protein conserved in bacteria (DUF2170) (137 a.a.), 12 papers
IPR019231: DUF2170. This family of various hypothetical prokaryotic proteins has no known function.
Overlapping families in CDD: YjfI
Members of DUF2170 whose function may be known:
DUF2583 (PF10762.12): Protein of unknown function (DUF2583) (88 a.a.), 12 papers
IPR019698: DUF2583. Some members in this entry are annotated as YchH however currently no function is known.
Overlapping families in CDD: PRK10692
Members of DUF2583 whose function may be known:
DUF2628 (PF10947.11): Protein of unknown function (DUF2628) (93 a.a.), 12 papers
IPR024399: DUF2628. Some members in this family of proteins have been annotated as YigF. Their function is currently unknown.
Members of DUF2628 whose function may be known:
DUF2770 (PF10968.11): Protein of unknown function (DUF2770) (36 a.a.), 12 papers
IPR024494: DUF2770. Members in this family of proteins from Enterobacteria are annotated as YceO; however, currently no function is known.
Members of DUF2770 whose function may be known:
DUF3128 (PF11326.11): Protein of unknown function (DUF3128) (79 a.a.), 12 papers
IPR021475: DUF3128. This is a group of eukaryotic proteins with no known function. Proteins in this entry include budding yeast Emi1, which is required for transcriptional induction of the early meiotic-specific transcription factor Ime1. Deletion of Emi1 affects mitochondrial morphology.
Members of DUF3128 whose function may be known:
DUF3461 (PF11944.11): Protein of unknown function (DUF3461) (125 a.a.), 12 papers
IPR020911: UPF0325. This entry describes proteins of unknown function.
Overlapping families in CDD: PRK13677
Members of DUF3461 whose function may be known:
DUF3689 (PF12463.11): Protein of unknown function (DUF3689) (315 a.a.), 12 papers
IPR022162: TRPC4AP. TRPC4AP is a substrate-specific adapter of a DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complex required for cell cycle control.
Members of DUF3689 whose function may be known:
DUF3715 (PF12509.11): Protein of unknown function (DUF3715) (151 a.a.), 12 papers
IPR022188: DUF3715. This domain is found in eukaryotes, and is approximately 170 amino acids in length. Proteins containing this domain include TASOR and FAM208B proteins.
Members of DUF3715 whose function may be known:
DUF3736 (PF12540.11): Protein of unknown function (DUF3736) (132 a.a.), 12 papers
IPR022207: GSE-like. This domain is found in genetic suppressor element coiled-coil proteins.
Members of DUF3736 whose function may be known:
DUF4457 (PF14652.9): Domain of unknown function (DUF4457) (323 a.a.), 12 papers
IPR027859: KATNIP_dom. This domain can found in eukaryotic proteins such as KATNIP. It repeats several times in the vertebrate KATNIP. KATNIP is a microtubule-associated ciliary base protein probably involved in microtubule regulation.
Members of DUF4457 whose function may be known:
DUF4592 (PF15262.9): Domain of unknown function (DUF4592) (127 a.a.), 12 papers
IPR028030: DUF4592. This domain of unknown function lies to the N terminus of the protein. This domain is found in eukaryotes and contains two completely conserved residues (L and A) that may be functionally important.
Overlapping families in CDD: PHA03247, PHA03307, PRK03427, PRK07003, PRK07764, PRK07994, PRK10263, PRK12323, PRK14951, PTZ00121, PTZ00249, PTZ00449, pneumo_PspA
Members of DUF4592 whose function may be known:
DUF4795 (PF16043.8): Domain of unknown function (DUF4795) (207 a.a.), 12 papers
IPR032013: DUF4795. This family of proteins is functionally uncharacterised. This family of proteins is found in eukaryotes. Proteins in this family are typically between 285 and 978 amino acids in length.
Overlapping families in CDD: Mplasa_alph_rch, SMC_prok_B, Smc
Members of DUF4795 whose function may be known:
DUF416 (PF04222.15): Protein of unknown function (DUF416) (188 a.a.), 11 papers
IPR007338: DUF416. This is a bacterial family of uncharacterised proteins.
Overlapping families in CDD: YjaG
Members of DUF416 whose function may be known:
DUF441 (PF04284.16): Protein of unknown function (DUF441) (139 a.a.), 11 papers
IPR007382: UPF0756_TM. This entry contains proteins of unknown function. They are predicted to be transmembrane proteins with 4 TM domains.
Overlapping families in CDD: YeaL
Members of DUF441 whose function may be known:
DUF554 (PF04474.15): Protein of unknown function (DUF554) (220 a.a.), 11 papers
IPR007563: DUF554. This is a family of uncharacterised prokaryotic proteins. Multiple predicted transmembrane regions suggest that the protein is membrane associated.
Overlapping families in CDD: YqgA
Members of DUF554 whose function may be known:
DUF999 (PF06198.14): Protein of unknown function (DUF999) (143 a.a.), 11 papers
IPR009340: DUF999. This is a family of conserved Schizosaccharomyces proteins with unknown function.
Members of DUF999 whose function may be known:
DUF1116 (PF06545.14): Protein of unknown function (DUF1116) (215 a.a.), 11 papers
IPR009499: DUF1116. This family contains hypothetical bacterial proteins of unknown function.
Members of DUF1116 whose function may be known:
DUF1246 (PF06849.15): Protein of unknown function (DUF1246) (122 a.a.), 11 papers
IPR010672: IMP_biosynth_PurP_N. The last two steps of de novo purine biosynthesis are: conversion of 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-monophosphate (FAICAR) conversion of FAICAR to inosine5'-monophopsphate (IMP) In bacteria and eukaryotes, these steps are catalysed by the well-characterised bifunctional enzyme PurH. Archaea do not appear to posses PurH, however, and perform these reactions by a different mecahnism. In archaea, step i)...
Overlapping families in CDD: CarB, PRK07206, PRK13277, PurP, RimK, purP
Members of DUF1246 whose function may be known:
DUF1283 (PF06932.14): Protein of unknown function (DUF1283) (83 a.a.), 11 papers
IPR009700: DUF1283. This family consists of several hypothetical proteins of around 115 residues in length, which seem to be specific to Enterobacteria. The function of the family is unknown.
Overlapping families in CDD: PRK13659
Members of DUF1283 whose function may be known:
DUF1297 (PF06973.15): Domain of unknown function (DUF1297) (188 a.a.), 11 papers
IPR009720: IMP_biosynth_PurP_C. The last two steps of de novo purine biosynthesis are: conversion of 5-aminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-monophosphate (FAICAR) conversion of FAICAR to inosine5'-monophopsphate (IMP) In bacteria and eukaryotes, these steps are catalysed by the well-characterised bifunctional enzyme PurH. Archaea do not appear to posses PurH, however, and perform these reactions by a different mechanism. In archaea, step i)...
Overlapping families in CDD: CarB, PRK07206, PRK13277, PurP, RimK, purP
Members of DUF1297 whose function may be known:
DUF1428 (PF07237.14): Protein of unknown function (DUF1428) (101 a.a.), 11 papers
IPR009874: DUF1428. This family consists of several hypothetical bacterial and one archaeal sequence of around 120 residues in length. The function of this family is unknown.
Overlapping families in CDD: YbaA
Members of DUF1428 whose function may be known:
DUF1801 (PF08818.14): Domain of unknown function (DU1801) (85 a.a.), 11 papers
IPR014922: DUF1801. This domain is found in the Intracellular iron chaperone frataxin ydhG and the uncharacterized protein YdeI from Bacillus subtilis.
Overlapping families in CDD: YdhG
Members of DUF1801 whose function may be known:
UPF0552 (PF10574.12): Arp2/3-interacting proteins Arpin (224 a.a.), 11 papers
IPR018889: Arpin. Arpin regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex. It induces cell turning by pausing cell migration.
Members of UPF0552 whose function may be known:
DUF2854 (PF11016.11): Protein of unknown function (DUF2854) (146 a.a.), 11 papers
IPR021275: DUF2854. This family of proteins has no known function.
Members of DUF2854 whose function may be known:
DUF3168 (PF11367.11): Protein of unknown function (DUF3168) (117 a.a.), 11 papers
IPR021508: Gp17-like. Gp17 from Siphoviridae bacteriophage SPP1 is a tail completion protein located at the interface between the connector protein gp16 and the tail of bacteriophage SPP1. Gp17 plays a fundamental role in the head-to-tail joining reaction, the ultimate step of virus particle assembly.
Members of DUF3168 whose function may be known:
DUF4211 (PF13926.9): Domain of unknown function (DUF4211) (139 a.a.), 11 papers
IPR025451: DUF4211. This presumed domain is functionally uncharacterised.
Members of DUF4211 whose function may be known:
DUF4223 (PF13978.9): Protein of unknown function (DUF4223) (54 a.a.), 11 papers
IPR025318: DUF4223. This family of proteins is functionally uncharacterised. Proteins in this family are approximately 60 amino acids in length and are predicted to be to be lipoproteins.
Members of DUF4223 whose function may be known:
DUF4460 (PF14687.9): Domain of unknown function (DUF4460) (110 a.a.), 11 papers
IPR028031: DUF4460. This domain of unknown function has a conserved HPD sequence motif. There are two completely conserved residues (N and F) that may be functionally important. The domain is found in eukaryotic proteins, including T-cell activation inhibitor which may have a role in regulation of T cell activation or apoptosis.
Members of DUF4460 whose function may be known:
CCDC92 (PF14916.9): Coiled-coil domain of unknown function (57 a.a.), 11 papers
IPR039496: CCDC92/74_CC_dom. This entry represents the coiled-coil domain found in uncharacterized proteins CCDC92 and CCDC74.
Overlapping families in CDD: Mplasa_alph_rch, PRK03918, SMC_prok_B, SbcC, Smc
Members of CCDC92 whose function may be known:
UPF0167 (PF03691.17): Uncharacterised protein family (UPF0167) (176 a.a.), 10 papers
IPR005363: UPF0167. The proteins in this family are about 200 amino acids long and each contain 3 CXXC motifs.
Overlapping families in CDD: CbrC
Members of UPF0167 whose function may be known:
DUF1131 (PF06572.15): Protein of unknown function (DUF1131) (170 a.a.), 10 papers
IPR010938: DUF1131. This entry consists of several hypothetical bacterial proteins of unknown function.
Overlapping families in CDD: PRK10718
Members of DUF1131 whose function may be known:
DUF1213 (PF06740.15): Protein of unknown function (DUF1213) (34 a.a.), 10 papers
IPR009603: MAP_Futsch. The Drosophila protein Futsch has homology to MAP1B and controls synaptic growth at the Drosophila neuromuscular junction through the regulation of the synaptic microtubule cytoskeleton. Futsch protein colocalises with microtubules and identifies cytoskeletal loops that traverse the lateral margin of select synaptic boutons. Futsch mutations disrupt synaptic microtubule organisation, reduce bouton number, and increase bouton size. These deficits can...
Overlapping families in CDD: MDN1, MSCRAMM_ClfA, MSCRAMM_ClfB, PHA00430, PHA03307, PLN03237, PRK07735, PRK13108, PRK14949, PTZ00108, PTZ00121, PTZ00341, PTZ00449, PspC_subgroup_1, infB, pneumo_PspA, rad2, rne
Members of DUF1213 whose function may be known:
UPF0257 (PF06788.16): Uncharacterised protein family (UPF0257) (235 a.a.), 10 papers
IPR010646: UPF0257. This is a group of proteins of unknown function.
Overlapping families in CDD: PRK02939
Members of UPF0257 whose function may be known:
DUF1418 (PF07214.15): Protein of unknown function (DUF1418) (94 a.a.), 10 papers
IPR010815: DUF1418. This family consists of several hypothetical Enterobacterial proteins of around 100 residues in length. Members of this family are often described as YbjC. In Escherichia coli the ybjC gene is located downstream of nfsA (which encodes the major oxygen-insensitive nitroreductase). It is thought that nfsA and ybjC form an operon an its promoter is a class I SoxS-dependent promoter....
Overlapping families in CDD: PRK10591
Members of DUF1418 whose function may be known:
DUF1456 (PF07308.16): Protein of unknown function (DUF1456) (68 a.a.), 10 papers
IPR009921: DUF1456. This domain occurs in several hypothetical bacterial proteins of around 150 residues in length. The function of this domain is unknown.
Overlapping families in CDD: YehS
Members of DUF1456 whose function may be known:
DUF1479 (PF07350.15): Protein of unknown function (DUF1479) (414 a.a.), 10 papers
IPR010856: DUF1479. This family consists of several hypothetical Enterobacterial proteins, of around 420 residues in length. Members of this family are often known as YbiU. The function of this family is unknown.
Members of DUF1479 whose function may be known:
DUF1488 (PF07369.14): Protein of unknown function (DUF1488) (82 a.a.), 10 papers
IPR009962: DUF1488. This family consists of several hypothetical bacterial proteins of around 85 residues in length. The function of this family is unknown.
Members of DUF1488 whose function may be known:
DUF1990 (PF09348.13): Domain of unknown function (DUF1990) (154 a.a.), 10 papers
IPR018960: DUF1990. This entry represents proteins that are functionally uncharacterised.
Overlapping families in CDD: COG4762
Members of DUF1990 whose function may be known:
DUF2135 (PF09906.12): Uncharacterized protein conserved in bacteria (DUF2135) (52 a.a.), 10 papers
IPR019220: DUF2135. This entry, found in various hypothetical prokaryotic proteins, has no known function.
Overlapping families in CDD: YfaP
Members of DUF2135 whose function may be known:
UPF0560 (PF10577.12): Uncharacterised protein family UPF0560 (817 a.a.), 10 papers
IPR018890: Uncharacterised_FAM171. This family of proteins has no known function.
Members of UPF0560 whose function may be known:
DUF2511 (PF10709.12): Protein of unknown function (DUF2511) (87 a.a.), 10 papers
IPR019648: DUF2511. This entry represents a family of uncharacterised proteins.
Members of DUF2511 whose function may be known:
DUF2635 (PF10948.11): Protein of unknown function (DUF2635) (46 a.a.), 10 papers
IPR024400: DUF2635. This family consists of uncharacterised proteins found in bacteria and bacteriophages. It includes protein Gp38 from Enterobacteria phage Mu.
Members of DUF2635 whose function may be known:
DUF3046 (PF11248.11): Protein of unknown function (DUF3046) (62 a.a.), 10 papers
IPR021408: DUF3046. This family of proteins are mostly found in Actinobacteria. This entry includes Rv2742c from Mycobacterium tuberculosis. Rv2742c is involved in preservation of envelope integrity and tolerance to surface stress.
Members of DUF3046 whose function may be known:
DUF3455 (PF11937.11): Protein of unknown function (DUF3455) (158 a.a.), 10 papers
IPR021851: DUF3455. This family of proteins are functionally uncharacterised. This protein is found in bacteria and eukaryotes. Proteins in this family are typically between 174 to 251 amino acids in length.
Members of DUF3455 whose function may be known:
DUF4201 (PF13870.9): Domain of unknown function (DUF4201) (177 a.a.), 10 papers
IPR025254: DUF4201. This is a family of coiled-coil proteins from eukaryotes. Their function is not known.
Overlapping families in CDD: SMC_prok_B
Members of DUF4201 whose function may be known:
DUF4203 (PF13886.9): Domain of unknown function (DUF4203) (201 a.a.), 10 papers
IPR025256: DUF4203. This domain of unknown function is often found in proteins from the transmembrane 7 superfamily.
Members of DUF4203 whose function may be known:
DUF4212 (PF13937.9): Domain of unknown function (DUF4212) (79 a.a.), 10 papers
IPR019886: Na_symporter_ssu_prd. Proteins matched by this entry are highly hydrophobic bacterial proteins of about 90 amino acids in length. They are usually found immediately upstream (sometimes fused to) a member of the solute:sodium symporter family, and are therefore putative sodium:solute symporter small subunits. They tend to be found in aquatic bacteria, especially those from marine or other high salt environments.
Overlapping families in CDD: COG4327, Na_symport_sm
Members of DUF4212 whose function may be known:
DUF4461 (PF14688.9): Domain of unknown function (DUF4461) (308 a.a.), 10 papers
IPR027989: DUF4461. This domain is found in eukaryotic proteins, including T-cell activation inhibitor, which may have a role in regulation of T cell activation or apoptosis.
Members of DUF4461 whose function may be known:
DUF4485 (PF14846.9): Domain of unknown function (DUF4485) (84 a.a.), 10 papers
IPR027831: DUF4485. This domain of unknown function is found in eukaryotic proteins, and is approximately 90 amino acids in length.
Overlapping families in CDD: 235kDa-fam, 46, COG4372, COG5281, EnvC, GumC, Mplasa_alph_rch, PLN02939, PRK00409, PRK01156, PRK03918, PRK04778, PRK12704, PTZ00121, PspC_subgroup_1, SMC_prok_A, SMC_prok_B, SbcC, Smc, Streccoc_I_II, pneumo_PspA, rad50, sbcc
Members of DUF4485 whose function may be known:
DUF4666 (PF15697.8): Domain of unknown function (DUF4666) (113 a.a.), 10 papers
IPR031421: DUF4666. This family of proteins is found in plants. Proteins in this family are typically between 103 and 140 amino acids in length. There are two conserved sequence motifs: LQRS and FRR. Proteins containing this domain includes Arabidopsis At1g15400 and At1g80180. At1g80180 is a MAPK kinase substrate that may play a role in the regulation of stomata patterning.
Members of DUF4666 whose function may be known:
DUF5009 (PF16401.8): Domain of unknown function (DUF5009) (260 a.a.), 10 papers
IPR032176: DUF5009. Proteins containing this DUF5009 domain are not characterised.
Overlapping families in CDD: COG4299
Members of DUF5009 whose function may be known:
DUF412 (PF04217.16): Protein of unknown function, DUF412 (141 a.a.), 9 papers
IPR007334: UPF0208. This family consists of bacterial uncharacterised proteins.
Overlapping families in CDD: PRK01816, YfbV
Members of DUF412 whose function may be known:
DUF480 (PF04337.15): Protein of unknown function, DUF480 (149 a.a.), 9 papers
IPR007432: DUF480. This family consists of several proteins of uncharacterised function.
Overlapping families in CDD: PRK11239, YceH
Members of DUF480 whose function may be known:
DUF494 (PF04361.16): Protein of unknown function (DUF494) (152 a.a.), 9 papers
IPR007456: Smg. This entry represents the Smg family of bacterial proteins. Their function is unknown.
Overlapping families in CDD: PRK03430, Smg
Members of DUF494 whose function may be known:
DUF905 (PF06006.15): Bacterial protein of unknown function (DUF905) (70 a.a.), 9 papers
IPR009253: DUF905. This family consists of several short hypothetical proteobacterial proteins of unknown function.
Members of DUF905 whose function may be known:
DUF986 (PF06173.15): Protein of unknown function (DUF986) (148 a.a.), 9 papers
IPR009328: DUF986. This family consists of several bacterial putative membrane proteins of unknown function.
Overlapping families in CDD: PRK02913, YobD
Members of DUF986 whose function may be known:
DUF1318 (PF07027.15): Protein of unknown function (DUF1318) (93 a.a.), 9 papers
IPR008309: UCP025560. There are currently no experimental data for members of this group or their homologues, nor do they exhibit features indicative of any function.
Overlapping families in CDD: YdbL
Members of DUF1318 whose function may be known:
DUF1376 (PF07120.14): Protein of unknown function (DUF1376) (86 a.a.), 9 papers
IPR010781: DUF1376. This family consists of several hypothetical bacterial proteins of around 95 residues in length. The function of this family is unknown. This entry includes Bacteriophage PBC5 (Sinorhizobium phage PBC5), Orf49. The characteristics of the protein distribution suggest prophage matches in addition to the phage matches.
Overlapping families in CDD: YdaU
Members of DUF1376 whose function may be known:
DUF1449 (PF07290.14): Protein of unknown function (DUF1449) (202 a.a.), 9 papers
IPR010840: DUF1449. This family consists of several bacterial proteins of around 210 residues in length. The function of this family is unknown.
Members of DUF1449 whose function may be known:
DUF1889 (PF08986.13): Domain of unknown function (DUF1889) (96 a.a.), 9 papers
IPR015079: DUF1889. This family consist of hypothetical bacterial proteins.
Members of DUF1889 whose function may be known:
DUF1980 (PF09323.13): Domain of unknown function (DUF1980) (181 a.a.), 9 papers
IPR015402: DUF1980. Members of this occur in gene pairs with members of . The N-terminal region contains several predicted transmembrane helix regions while the few invariant residues (G, CxxD, and W) occur in the C-terminal region. Members of this family are found in a set of prokaryotic hypothetical proteins. Their exact function has not, as yet, been defined.
Overlapping families in CDD: TIGR03943, YcgQ
Members of DUF1980 whose function may be known:
DUF2138 (PF09909.12): Uncharacterized protein conserved in bacteria (DUF2138) (555 a.a.), 9 papers
IPR018671: DUF2138. This family of conserved hypothetical proteins has no known function.
Overlapping families in CDD: PRK11410, YfaA
Members of DUF2138 whose function may be known:
DUF2559 (PF10832.11): Protein of unknown function (DUF2559) (54 a.a.), 9 papers
IPR022541: DUF2559. This family of proteins appear to be restricted to Proteobacteria. The sequences are annotated as YhfG however currently no function is known.
Overlapping families in CDD: PRK10204
Members of DUF2559 whose function may be known:
DUF2645 (PF10840.11): Protein of unknown function (DUF2645) (98 a.a.), 9 papers
IPR022553: DUF2645. This family of proteins appears to be restricted to Enterobacteriaceae. Some members in the family are annotated as inner membrane protein YjeO. However no function is currently known.
Members of DUF2645 whose function may be known:
DUF2810 (PF10928.11): Protein of unknown function (DUF2810) (53 a.a.), 9 papers
IPR021230: DUF2810. This is a bacterial family of uncharacterised proteins. This entry contains YibL ( ), which comigrates with the mature 50S ribosome subunit. It either represents a novel ribosome-associated protein or it is associated with a different oligomeric complex that comigrates with ribosomal particles.
Overlapping families in CDD: PRK11020
Members of DUF2810 whose function may be known:
DUF2756 (PF10956.11): Protein of unknown function (DUF2756) (104 a.a.), 9 papers
IPR020158: DUF2756. This entry contains proteins with no known function.
Overlapping families in CDD: PRK10350
Members of DUF2756 whose function may be known:
DUF2767 (PF10965.11): Protein of unknown function (DUF2767) (67 a.a.), 9 papers
IPR024493: FumD. Fumarase D (YdhZ) catalyzes in vitro the addition of water to fumarate, forming malate.
Overlapping families in CDD: PRK10292
Members of DUF2767 whose function may be known:
DUF4470 (PF14737.9): Domain of unknown function (DUF4470) (100 a.a.), 9 papers
IPR027974: DUF4470. This domain of unknown function is conserved from fungi to Metazoa and plants. It is sometimes found in proteins that have a zinc-finger domain, zf-MYND ( ) at their very C terminus. In other cases it is associated with , as in axonemal dynein assembly factor 3.
Members of DUF4470 whose function may be known:
DUF4471 (PF14740.9): Domain of unknown function (DUF4471) (304 a.a.), 9 papers
IPR028235: DNAAF3_C. This domain of unknown function is found in a number of proteins, including dynein assembly factor 3 (DNAAF3), which is required for the assembly of axonemal inner and outer dynein arms. DNAAF3 is involved in preassembly of dyneins into complexes before their transport into cilia.
Members of DUF4471 whose function may be known:
DUF4477 (PF14780.9): Domain of unknown function (DUF4477) (189 a.a.), 9 papers
IPR027951: DUF4477. This entry represents a domain of unknown function in proteins from eukaryotes, including human uncharacterised protein C3orf17.
Members of DUF4477 whose function may be known:
DUF4503 (PF14951.9): Domain of unknown function (DUF4503) (392 a.a.), 9 papers
IPR028032: DUF4503. This domain of unknown function is found in eukaryotic proteins that are, as yet, uncharacterised.
Members of DUF4503 whose function may be known:
DUF4605 (PF15378.9): Domain of unknown function (DUF4605) (59 a.a.), 9 papers
IPR027953: DUF4605. This domain of unknown function is found in eukaryotes.
Members of DUF4605 whose function may be known:
DUF5105 (PF17118.8): Domain of unknown function (DUF5105) (189 a.a.), 9 papers
IPR031343: DUF5105. This entry represents a domain found in a group of uncharacterised bacterial proteins. Its function is not known. Proteins containing this domain include a putative lipoprotein, ycdA, whose structure has been revealed (PDB:4r4g).
Members of DUF5105 whose function may be known:
DUF5309 (PF17236.5): Family of unknown function (DUF5309) (283 a.a.), 9 papers
IPR035198: DUF5309. This is a family of uncharacterised proteins found in Bacteria.
Members of DUF5309 whose function may be known:
DUF6736 (PF20521.1): Family of unknown function (DUF6736) (131 a.a.), 9 papers
Members of DUF6736 whose function may be known:
UPF0181 (PF03701.17): Uncharacterised protein family (UPF0181) (50 a.a.), 8 papers
IPR005371: UPF0181. This family contains small proteins of about 50 amino acids of unknown function. The family includes YoaH ( ).
Overlapping families in CDD: PRK05114, yoaH
Members of UPF0181 whose function may be known:
DUF370 (PF04025.15): Domain of unknown function (DUF370) (73 a.a.), 8 papers
IPR007169: RemA. This family of mostly uncharacterized proteins includes the extracellular matrix regulatory protein A (RemA) from Bacillus subtilis . RemA is required for biosynthesis of the extracellular matrix and biofilm formation. It binds to DNA at multiple sites upstream of the promoters of the operons eps and tapA-sipW-tasA, which are required for the synthesise of the extracellular matrix components, extracellular...
Overlapping families in CDD: PRK04323, RemA
Members of DUF370 whose function may be known:
DUF577 (PF04510.15): Family of unknown function (DUF577) (173 a.a.), 8 papers
IPR007598: DUF577. This domain is found in Arabidopsis thaliana (Mouse-ear cress) proteins which are specifically expressed during meiosis. Many of these members contain a repeated region.
Members of DUF577 whose function may be known:
DUF1156 (PF06634.15): Protein of unknown function (DUF1156) (72 a.a.), 8 papers
IPR009537: DUF1156. This entry represents a conserved region within hypothetical prokaryotic and archaeal proteins of unknown function.
Overlapping families in CDD: COG1743, PRK14968, TrmN6
Members of DUF1156 whose function may be known:
DUF1314 (PF07013.14): Protein of unknown function (DUF1314) (179 a.a.), 8 papers
IPR010741: DUF1314. This family consists of several alphaherpesvirus proteins of around 200 residues in length. Their function is unknown.
Overlapping families in CDD: PHA03371
Members of DUF1314 whose function may be known:
DUF1454 (PF07305.15): Protein of unknown function (DUF1454) (189 a.a.), 8 papers
IPR009918: DUF1454. This family consists of several Enterobacterial sequences of around 200 residues in length, which are often known as YiiQ proteins. The function of this family is unknown.
Members of DUF1454 whose function may be known:
DUF1461 (PF07314.14): Protein of unknown function (DUF1461) (181 a.a.), 8 papers
IPR010178: Integral_membrane_1906. This entry represents a family of highly hydrophobic, uncharacterised predicted integral membrane proteins found almost entirely in low-GC Gram-positive bacteria, although a member is also found in Aquifex aeolicus.
Overlapping families in CDD: COG4478, integ_TIGR01906
Members of DUF1461 whose function may be known:
DUF1687 (PF07955.14): Protein of unknown function (DUF1687) (128 a.a.), 8 papers
IPR012882: Fmp46. This entry includes a group of putative redox proteins from fungi, including Fmp46 from yeasts.
Members of DUF1687 whose function may be known:
DUF2002 (PF09400.13): Protein of unknown function (DUF2002) (110 a.a.), 8 papers
IPR018994: DUF2002. This entry represents a group of putative cytoplasmic proteins. The structure of these proteins form an antiparallel beta sheet and contain some alpha helical regions.
Overlapping families in CDD: PRK10556
Members of DUF2002 whose function may be known:
DUF2574 (PF10836.11): Protein of unknown function (DUF2574) (93 a.a.), 8 papers
IPR020386: Uncharacterised_YehE. This entry contains proteins with no known function.
Members of DUF2574 whose function may be known:
DUF2773 (PF10971.11): Protein of unknown function (DUF2773) (81 a.a.